NEED A LITTLE HELP

[pointman]

I NEED A RECOMMENDATION ON A ANTI-ESTROGEN AND DIANABOL. PROVIRON VERSUS NOLVADEX AND WHY. DIANABOL (ANABOL) BRITISH DISP (THAILAND) 5 MG/TAB VERSUS DIANABOL (NAPOSIM) (TERAPIA ROMANIA) 5MG/TAB. AND WHY. ALSO GENERALLY WHAT IS THE SHELF LIFE WILL IT KEEP FOR A YEAR. THANKS FOR THE HELP.

[LuvMuhRoids]

Lot of questions in one post...lol I can answer your anti estrogen products at least. Difference between proviron and nolvadex is nolvadex is a SERM (Selective Estrogen Receptor Modulator) and is an estrogen blocker. Nolvadex mimics estrogen to fill receptors instead of estrogen. There needs to be a balance between androgen and estrogen levels. An estrogen flood to these receptors could possibly hinder gains and lead to gyno symptoms.

Proviron is an AI (Aromitise Inhibitor). Proviron also has androgenic properties but is not a steroid. Helps stimulate sexual libido during steroid use because of the testes shut down. Proviron stops the conversion of estrogen from the beginning thus stops or inhibits the aromatizing all together. Both are recommendable during a cycle or PCT (Post Cycle Therapy). In my opinion a nolvadex/l-dex combo is more recommendable to keep estrogen in check.

Recommended dosage of l-dex at .25mg ED and nolva at 10mg ED through out a cycle. L-dex is not needed necessarily but like I mentioned recommendable for a strong therapy against estrogen build up. During PCT run l-dex at same dosage and up the nolvadex to 20mg ED along with clomid treatment. Run nolva/l-dex combo 30days.

Also, the differences between these dbol products is virtually nothing but the grade made by the chemist. Some grade products are more bio consumable than others. British is more recommendable over napoism but I get napoism much more cheaper so I dont care either way. To me dbol is dbol but others may differ.

LMR

Originally posted by pointman
I NEED A RECOMMENDATION ON A ANTI-ESTROGEN AND DIANABOL. PROVIRON VERSUS NOLVADEX AND WHY. DIANABOL (ANABOL) BRITISH DISP (THAILAND) 5 MG/TAB VERSUS DIANABOL (NAPOSIM) (TERAPIA ROMANIA) 5MG/TAB. AND WHY. ALSO GENERALLY WHAT IS THE SHELF LIFE WILL IT KEEP FOR A YEAR. THANKS FOR THE HELP.

[MuGGsy]

caps lock off before migraines persist

[pointman]

THANKS FOR THE RESPONSE.

[Skyefire]

All caps is SHOUTING. please don't do it.

[buyb12]

Letrozol is femera, which is an anti-estrogen.

Femara is 10-30x more effective than Arimidex in it's ability to pass thru the cell membrane of lipid (fat) cells and inhibit the activity of aromatase -- in other words, Femara is far superior in lowering estrogen levels in fat cells. This has two benefits for BBs; (1) Estrogen 'attracts' water, so less water retention (2) an average male BB is around 10%BF, that's a lot of lipid cells with aromatase inside them, so a substantial percentage of aromatase is left untouched by Arimidex due to it's poor ability to enter lipid cellsArimidex is approximately 80% effective at inhibiting aromatase, Femara is around 95-97%
notes:
1. J Clin Endocrinol Metab 2000 Jul;85(7):2370-7
2. J Steroid Biochem Mol Biol 1997 Nov-Dec;63(4-6):261-7

[LuvMuhRoids]

True, femara is stronger than dex but suppresses HDL levels considerably and decreases libido. I feel a SERM is a necessity to run during ones cycle, and Nolva in conjunction with Femara, reduces Femara blood plasma levels by 37.6%. No studies have shown this to be the case with anastrozole(L-dex). Also, femara has a serious effect of the lipid panel.

Impact of tamoxifen on the pharmacokinetics and endocrine effects of the aromatase inhibitor letrozole in postmenopausal women with breast cancer.

Dowsett M, Pfister C, Johnston SR, Miles DW, Houston SJ, Verbeek JA, Gundacker H, Sioufi A, Smith IE.

Department of Biochemistry, Royal Marsden Hospital, London, United Kingdom.

This study examined whether the addition of tamoxifen to the treatment regimen of patients with advanced breast cancer being treated with the aromatase inhibitor letrozole led to any pharmacokinetic or pharmacodynamic interaction. Twelve of 17 patients completed the core period of the trial in which 2.5 mg/day letrozole was administered alone for 6 weeks and in combination with 20 mg/day tamoxifen for the subsequent 6 weeks. Patients responding to treatment continued on the combination until progression of disease or any other reason for discontinuation. Plasma levels of letrozole were measured at the end of the 6-week periods of treatment with letrozole alone and the combination and once more between 4 and 8 months on combination therapy. No further measurements were done thereafter. Hormone levels were measured at 2-week intervals throughout the core period. Marked suppression of estradiol, estrone, and estrone sulfate occurred with letrozole treatment, and this was not significantly affected by the addition of tamoxifen. However, plasma levels of letrozole were reduced by a mean 37.6% during combination therapy (P<0.0001), and this reduction persisted after 4-8 months of combination therapy. Letrozole is the first drug to be described in which this pharmacokinetic interaction occurs with tamoxifen. The mechanism is likely to be a consequence of an induction of letrozole-metabolizing enzymes by tamoxifen but was not further addressed in this study. It is possible that the antitumor efficacy of letrozole may be affected. Thus, sequential therapy may be preferable with these two drugs. It is not known whether tamoxifen interacts with other members of this class of drugs or with other drugs in combination.

Originally posted by buyb12
Letrozol is femera, which is an anti-estrogen.

Femara is 10-30x more effective than Arimidex in it's ability to pass thru the cell membrane of lipid (fat) cells and inhibit the activity of aromatase -- in other words, Femara is far superior in lowering estrogen levels in fat cells. This has two benefits for BBs; (1) Estrogen 'attracts' water, so less water retention (2) an average male BB is around 10%BF, that's a lot of lipid cells with aromatase inside them, so a substantial percentage of aromatase is left untouched by Arimidex due to it's poor ability to enter lipid cellsArimidex is approximately 80% effective at inhibiting aromatase, Femara is around 95-97%
notes:
1. J Clin Endocrinol Metab 2000 Jul;85(7):2370-7
2. J Steroid Biochem Mol Biol 1997 Nov-Dec;63(4-6):261-7

[Stonecold54]

Originally posted by pointman
I NEED A RECOMMENDATION ON A ANTI-ESTROGEN AND DIANABOL. PROVIRON VERSUS NOLVADEX AND WHY. DIANABOL (ANABOL) BRITISH DISP (THAILAND) 5 MG/TAB VERSUS DIANABOL (NAPOSIM) (TERAPIA ROMANIA) 5MG/TAB. AND WHY. ALSO GENERALLY WHAT IS THE SHELF LIFE WILL IT KEEP FOR A YEAR. THANKS FOR THE HELP.

FOR THOSE THAT WANT HELP WITH CYCLES