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#1
12-14-04, 12:59 PM
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Anti-estrogen
OK so I know what anti-estrogens that are the most commonly used in this sport.
My question is about a drug that I have heard of from some guys in my Gym. They spoke about a drug called DUFFIN, claiming that is much more efective than Novaldex. I've searched a bit but I found no references to this drug. Does anyone know this? 
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#2
12-14-04, 02:50 PM
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Never heard of it???
I'll bump this up for ya. Does it work like nolvadex or like arimidex?
__________________
Knowledge is power. Any and All things said by Lmg2701 are for role playing purposes only, nothing should be taken literally. Lmg2701 does not condone nor does he use any type of illegal substance/substances.
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#5
12-14-04, 07:12 PM
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Quote:
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#6
12-14-04, 07:14 PM
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Re: Anti-estrogen
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#7
12-15-04, 06:21 AM
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Re: Anti-estrogen
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If there was anything better for fighting the big E, you would know about it here. As mentioned elsewhere on this board, Nolvadex blocks estrogen from attaching at the receptors whereas, Liquidex/Armidex, Letrozole and Aromasin stop the initial production of estrogen and are considered "suicide inhibitors" because they attach themselves irreversibly to the aromatase enzyme making it unusable and starving that tissue of estrogen needed in the formation of breast tissue and also in fighting against water bloat associated with elevated estrogen levels resulting from AAS use. Do a forum search and read up about anti-estrogens. It will save you from growing boobs- unless of course, that's your primary goal. 
__________________
"If we knew what it was we were doing, it would not be called research, would it?" - Albert Einstein "Mister, we deal in lead." - Steve McQueen, in The Magnificent Seven
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#8
12-15-04, 04:26 PM
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What is stated above isn't exactly correct. There are 3 basic classes of drugs used to combat estrogen:
First line: SERM's - Selective Estrogen Receptor Modulators, typically nolvadex, basically attaches to ER site thus preventing attachment of stronger estrogen/estradiol. Second line: Anti-aromatase/aromatase inhibitors. Early ones include Aminoglutethimide and later Arimidex, and Letrozole. Basically works by preventing the conversion of test to estradiol by inhibiting the formation of the CYP19 enzyme, thus reducing estro creation. Third line: Suicidal aromatase inhibitors. These include exemestane (Aromasin) and formestane. Basically work by permanently binding to and inactivating the enzyme aromatase (CYP19), which the body uses to make estradiol. Again works by stopping creation of estro. As you can see line 2 and 3 defenses work by stopping creation, therefore they are useless against estrogen that is already in your body freely circulating. That's why once you have signs of gyno, nolva + a line 2 or 3 defense is best since it will stop the estro that is currently in your body from further binding (nolva does that), and it stops the creation of additional estrogen (line 2 or 3 defense drug). hope this helps clear this up a bit, DrG
__________________
"A foolish consistency is the hobgoblin of little minds" – Ralph Waldo Emerson "I might be carb depleted but I am not brain dead" - Milos Sarcev Last edited by drgoodbody : 12-15-04 at 04:29 PM.
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#9
12-15-04, 05:50 PM
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drgoodbody, so if you use the suicidal aromatase inhibitors you dont need to worry at all about estrogen?
__________________
Everything Kingj says is for entertainment purposes only. I am not a source, Do not ask me for a Source. I do not encourage the use of illegal substances or use them myself.
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#10
12-16-04, 09:01 AM
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Quote:
BTW, I personally use formestane + nolvadex and have never had an issue. DrG
__________________
"A foolish consistency is the hobgoblin of little minds" – Ralph Waldo Emerson "I might be carb depleted but I am not brain dead" - Milos Sarcev
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