GYNO FROM DROL

[kingj]

I was told that the gyno you get from drol is prolactin, is this true i always thought it was the normal estrogen gyno you get from test.

[jipped genes]

well i have been useing drol for a while now and have found that i get no symptoms at all and very little bloat using 12.5 mg of aroma ed and 50mg of proviron. i know aroma is an AI but it seems to help.

[kingj]

well the reason i ask is because im really pron to prolactin gyno, so im trying to avoid any gear that can cause this.

[spidey]

Anadrol is a powerful progestin and yes it is pretty renowned for causing gyno.

[kingj]

What would be a good anti prolactin/progestin to use with tihs?

[spidey]

My first choice will always be vitamin B6. It is certainly the safest antiprolactin available with the lowest occurence of sides.

I would start with 200 mg ed at the start of the cycle and if you start to see a problem, you can add in some nolva and temporarily boost the B6 to 400 mg ed. You shouldn't stay at that high of a dosage for more than a couple weeks though since some neurological sides can occur at that dosage.

[buyb12]

if you cut the estrogen you won't have prolactin or progestrone ......Letrozole is the best thing you can use for that .. It will also reverse gyno......b6 will help to lower prolactin

Vitamin B6 fights prolactin


The following are excerpted from OB/GYN class notes:
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Suppression of Lactation:

When the mother chooses not to breast feed or the baby is lost, suppression of lactation may be required. Initially the breasts get engorged, however in the absence of suckling further milk production stops on its own. Firm support to the breasts is helpful in reducing the discomfort. Manual expression is not very helpful as it promotes further milk secretion. Estrogens in high doses can suppress lactation, however there are side effects and the risk of venous thrombosis, hence these are not recommended. Bromocryptine, a dopamine agonist, given 2.5 mg twice a day for 14 days can suppress lactation by producing a fall in prolactin levels. This therapy is expensive, has side effects and there may be rebound lactation once the drug is stopped. FDA no longer approves it. Pyridoxine – Vitamin B6, given 200 mg three times a day for 5-7 days is quite effective in suppressing lactation and the drug has no side effects.
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Got Wood? note : adding Bromo to your cycle only adds to the potential anabolic cascade, and potentially negative drug interactions. In medicine B6 is supposed to be as effective as Bromo. Plus vitamin B6 has few side effects.
Here are a few of many studies supporting the use of Vitamin B6 in reducing prolactin:
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J Clin Endocrinol Metab 1976 Mar;42(3):603-6


Effect of pyridoxine on human hypophyseal trophic hormone release: a possible stimulation of hypothalamic dopaminergic pathway.

Delitala G, Masala A, Alagna S, Devilla L.

A single dose of pyridoxine (300 mg iv) produced significant rises in peak levels of immunoreactive growth hormone GH and significant decrease of plasma prolactin PRL in 8 hospitalized healthy subjects. Serum glucose, luteinizing hormone LH, follicle stimulating hormone FSH and thyrotropin TSH were not altered significantly. In addition, in 5 acromegalic patients who were studied with both L-dopa and pyridoxine, inhibition of GH secretion followed either agent in a similar pattern. These data suggest a hypothalamic dopaminergic effect of pyridoxine.

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N Engl J Med 1982 Aug 12;307(7):444-5

Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise.

Moretti C, Fabbri A, Gnessi L, Bonifacio V, Fraioli F, Isidori A.

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Boll Soc Ital Biol Sper 1984 Feb 28;60(2):273-8

[Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects]

[Article in Italian]

Barletta C, Sellini M, Bartoli A, Bigi C, Buzzetti R, Giovannini C.

The influence of vitamin B6 in a dosage of 300 mg X 2 in 24 hrs, on circadian rhythm of plasmatic ACTH, cortisol, prolactin and somatotropin have been studied in 10 normal women. After vitamin B6 24 hrs pattern of ACTH and cortisol is unchanged; prolactin levels are slightly lower, in a statistically unsignificant proportion the night peak of growth hormone is higher in a statistically significant proportion (p. 0.05). The effect of vitamin B6 is likely to me mediated by dopaminergic receptors at hypothalamic level as previous studies by other Authors appear to prove.