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Old 09-01-03, 03:37 PM
Question Humalin-R or Humalog?
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I've never ran slin. I've thought about using slin along with PCT after this cycle. I'm not sure weather to use Humalin-R or Humalog. I know the difference between the 2 and i've done alot of reading. I'm assuming for a newbie to slin that Humalog would be better?
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Old 09-01-03, 03:38 PM
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I like humalog, for me, the peak is more predictable, and it is in and out quick, thus not blocking normal lipolysis.
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Old 09-01-03, 04:06 PM
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I like humulin-R. allows you to get the extra meal in.
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Old 09-01-03, 05:06 PM
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bouncer is right. humilin r has better anabolic properties than humalog, but is more unpredictable. if you do your research and are sure of yourself, use humilin r, if you arent, use humalog.
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Old 09-01-03, 05:24 PM
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I would opt for Humalog in your case...Plan on at least 10 grams of carbs per IU of slin....Go slow at first, to see how you will react to it...Post workout, try 3iu's, 45 grams of carbs....BUT, the key is to take in PROTEIN...Insulin is the most anabolic thing(aside from food) you can put in your body....

Research very well...and up the dosage slowly, better safe than sorry my man......

Let me dig up a bit of info, and I'll post it as well.....

Ranger
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Old 09-01-03, 05:39 PM
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This should answer almost all your questions...BUT, take it slow, remember, some of these guys that take 10 to 20iu's at a time are HUGE!!! What works well for one, and be safe, may not be so for the other....<wink>

Enjoy:



Ok, lets have a look at insulin.
Its highly anabolic and non-androgenic, and in case some of you are in the dark (I'd like to think we're all clear on anabolic versus androgenic, but ya never know) I'll briefly touch on the subject before diving in... if youre ok on anabolic/androgenic concepts, skip to the INSULIN part...

ANDROGENIC VERSUS ANABOLIC

ANABOLIC is defined as "The process of constructive metabolism" or of building complex substances out of simple substances.
The way your body processes protien, carbohydrates, and fat (all simple substances) and makes muscle (a complex substance) is ANABOLISM.

ANDROGENIC is basically defined as pertaining to male sex characteristics.

ANDROGENIC/ANABOLIC

"Steroids" are actually called "Anabolic Androgenic Steroids." They accomplish "anabolism" through "anabolic" pathways, some being more androgenic (testosterone esters) and some less (winstrol, anavar, primobolan, ect...).
Most often, with reduced androgenic properties comes reduced anabolic properties, but it isnt always cut and dry. If anyone is interested I'll go into it another time, but lets head toward the insulin topic.


INSULIN: NonAndrogenic but Anabolic

Insulin is NOT a sex hormone. It is not related in any way to testosterone, or to estrogen for that matter. It is a product of the pancreas as opposed to testosterone which is a product of the HPTA, pituitary, gonadal, leydig, mishmash of interconnected glands...


WHY IS INSULIN ANABOLIC

So why is insulin anabolic then? Insulin is a partitioning agent. A "shuttle" if you will.
Picture insulin as a bus. Nutrients board the bus, and insulin pulls away and drops off the nutrients at the proper bus stop. That is basically what it does, and for all intents and purposes that is everything you need to know to understand how it works.
So by insulin shuttling these nutrient where they need to go, it enables anabolism and is therefor anabolic!


WHY NOT JUST TAKE CARBS TO RAISE INSULIN

Well, the amount of carbs you would need to take in to increase natural insulin levels to the degree a 10 i.u. shot would would be far more dangerous than using insuiln (and using insulin is NOT that hard OR dangerous).
Carbs at that level would eventually lead to diabetes and fat gains.
If insulin is a bus taking nutrients where they need to go, then exogenous insulin is a bullet train! It can hold far more nutrients than a normal naturally produced burst of insulin can, and it works quicker. Exogenous insulin is the most efficient way to accomplish glycogen overcompensation, period.


WHAT KIND DO I TAKE

Im a major supporter of fast acting insulin. The faster the better!
Currently he fastest acting insulin available is Humalog. It is active in 15 minutes, peaks in 1 hour and clears the system around 2 hours.
Next would be Humalin-R. It is active in about 30 minutes, peaks at the 2 hour mark, and clears the system at the 4 hour mark.
"Biophasics" are mixtures of fast and slow acting insulins, but are not the best choice in my opinion, due to an active dose being in you throughout the day. The reason you dont want that will be covered in the "HOW DO I USE IT" section.
There are also Humalin-L and Humalin-S, but they are long acting, and are no more use to me than the Biophasics. There are also porccine and bovine derived insulin, but I am against injecting animal derived substances.

WHEN (AND HOW MUCH) TO USE

Im going to assume we want to avoid any fat gains at all. Even bulking I dont like to gain any unneccesary fat, so Im going to disuss it from that stand point.
The ultra conservative time to use insulin is post-workout. Most people who are concerned about fat dont go over 10 i.u. as a total dose.
Some people us it on waking, before breakfast, since your body is in a basically carb depleted state. Its the kind of thng you have to try for yourslef, and if it works for you, do it. If you thnk youre gaining fat, stop. BUT! Dont start it at both times at once. Make sure you get your post workout dosage worked out and that you know it is not causing you any fat gains before you try pre-breakfast shots. That way you can take out all the guess work as to where any fat gains may come from.


DISPELLING A FEW MYTHS

There is a commoly held perception that you MUSt take in 10grams of carbs per I.U. of insulin, some radicals say 5 grams... well, theyre both wrong.
I got curious about this when I discovered that my insulin dependant diabetic friend didnt even keep track of what she ate post injection. She would feel hypoglycemic after a shot and take a Glucose Tablet.
A glucose tablet is only 5 grams of glucose (carbs)! So I started to think, "Hmmm, mabye everyone is off point on this?"
After conducting a few experiments on myself, I found that you can go considerably lower in carbs than people previously believed.
Now it doesnt make sense to go low in carbs, because that defies the purpose of using the insulin in the first place, but it does free us from having to use so much that there might be some "spill over" in carbs that cant be utilized. So it really makes us able to have more freedom in carbs choices and amounts.
The "risk" in insulin use is not as risky as people believe. Any person with an ounce of sense can see the warning signs of a problem coming, and remedy the situation.

HOW DO I DO IT

If you look at the drug store, you can get these little pen cases that hold a loaded insulin syringe. They are great for our need, you load up the syringe, and put it in the case, and throw it in your bag/purse/whatever. After the workout, head to a bathroom stall and inject it under the skin! Pull up a little skin from the abdomen or upper thigh (anywhere will do, but these are easiest) and inject. Do not shoot into a muscle. This rushes the dose and makes it harder to predict when it will spike.
So now you have 15 minutes to get some carbs (actually you have longer, since the initial hit of the dose is mild and easy to cope with, the spike is a little more harsh, but still nothing unbearable. If you use the carbs, you probobly wont notice the initial dose OR the spike.)
(this is based on Humalog at 10 i.u.)
I use a powder with a 20% simple/80% complex ratio (actually its 17% mono, 5% di, 7% tri, 5%tetra, and 66% penta-saccharides). I use about 60grams of carbs to the 10 i.u. of insulin.
This gives me a nice solid stream of carbs to overcompensate my depleted muscles, but not so many that I risk fat accumulation from the excess.
Now you are good to go till around 1 hour after the initial injection. At this 1 hour mark, the majority of the dose hits your system. Now is the time to eat a good balanced (AND FAT FREE!) meal. The fat-free emphasis will be explained in the POTENTIAL PROBLEMS section. This balance meal of carbs and protien and little to know fat can be anything from a protien drink and a crab drink, to a low fat MRP, to some lean chicken and rice... your choice.
After this meal, you dont need to pay anymore consideration to the insulin, it will gradually decrease and will be out of your system at the 2 hour mark.
Till you get accustmed to the use of insulin, start low and slow. Start at 2 i.u. then 5 i.u. then 7 i.u. then 10 i.u. That way you get a better understanding of any hypoglycemia you may encounter. Ive went as high as 35 i.u., just to try it, but at a certain point a higher dosage doesnt yield any better results (except fat!)

POTENTIAL PROBLEMS

Insulin is relativly safe. If you dont take in any carbs after using it, your body will give you PLENNTY of warning! Youll feel dizzy, tired, achey... hypoglycemic. What is happening is your body has no glycogen to use as fuel. Your muscles re depleted from working out, and often times youve tapped your liver for any remaining glycogen. The insulin does, searching for glycogen to use, takes the rest from your liver, and in the absence of carbs coming in to make more, it heads for the brain.
Your brain uses glucose as its primary fuel source (a little fat, too.) Thats why you get dizzy and light headed, the same with during a ketogenic diet... low glucose equals light headedness.
So if you forget about the carbs, youll get a warning from yuor body, and you can get your ass in gear and get some carbs in you.
If you get to the point where youre nauseated, just drink some sugary beverage and get some carbs in you quickly. Youre still a long long way from any major danger, but dont mess around.
"Fat Free" I said earlier about the 1 hour mark meal. During the 2 hours of the dosage duration, you should avoid fat like it is the plauge! Insulins partitioning properties are as effective at sending fat to the fat stores as it is carbs and protien to muscles!
So till the dose is clear of your system, NO FAT! (Thats another reason why I advocate the fastest acting insulin you can get.)


Well, I cant think of anything else off hand that needs to be said, but if I missed anything, just ask. I may have taken somethng for granted and figured everyone would know or assume on their own...


WHAT WAS THE CAUSE OF THE 20-30LB BODYWEIGHT JUMPS FROM 1994-PRESENT. I MEAN
LETS FACE IT, NASSER EL SONBATY WAS AN AVERAGE PRO UNTIL 1995 AND RONNIE
COLEMAN WAS A 2ND OR 3RD TIER ATHLETE UP UNTIL 1997, JEAN PIERRE FUX GAINED 40
LBS OF TISSUE IN A YEAR AND A HALF, CHRIS CORMIER HAS GONE FROM AVERAGE TO TOP
3, HELL EVEN DORIAN WENT FROM 230LBS TO 260LBS SEEMINGLY OVERNIGHT. ALL OF
THESE MEN HAVE HAD LOTS OF EXPERIENCE WITH STEROIDS AND G.H. SO THERE HAD TO
BE ANOTHER FACTOR. AT FIRST IT WAS THOUGHT IGF-1 WAS RESPONSIBLE, BUT THIS
PROVED TO BE A RATHER INEFFECTIVE COMPOUND.

SO WHAT WAS IT? WELL LET'S BEGIN THE INTERVIEW.


THIS QUESTION HAS BEEN ON EVERYONE'S MIND SINCE THE EMERGENCE OF 280-290LB
BODYBUILDERS FROM SEEMINGLY OUT OF NO-WHERE. I ALWAYS THOUGHT IT MUST HAVE
BEEN THE EMERGENCE OF IGF-1, BUT THEN AFTER RESEARCHING SOME THINGS, I FOUND
OUT THAT IGF-1 IS A SHIT DRUG AND DOESN'T DO MUCH. WHAT GIVES?

I N S U L I N! THAT'S WHAT GIVES! I'VE KNOWN A LOT OF THESE GUYS FOR A WHILE
NOW AND I CAN UNEQUIVOCALLY TELL YOU THAT IT IS THE RESULT OF INSULIN THAT
THESE HUGE LEAPS HAVE BEEN MADE.

INSULIN? IF THAT IS THE CASE, THEN HOW COME SO MANY PEOPLE CLAIM IT WILL MAKE
YOU FAT

BECAUSE IT CAN MAKE YOU FACT IF YOU DO NOT KNOW WHAT YOU ARE DOING AND DO NOT
USE THE RIGHT TYPE.

CAN YOU EXPLAIN HOW TO USE IT SO ONE WOULD NOT GET FAT.

ACTUALLY IT'S QUITE SIMPLY. YOU SEE THERE ARE DIFFERENT TYPES OF INSULIN L, N,
R , AND HUMALOG. THE DIFFERENCE IS IN THE ACTING TIMES. L LASTS IN THE SYSTEM
FOR AROUND 24HOURS PEAKING SEVERAL TIMES THROUGHOUT THE DAY AND TAKES 2 HOURS
TO BEGIN TO WORK, N IS MEDIUM IN ITS ACTING TIME LASTING AROUND 12 HOURS AND R
IS THE QUICKEST OF THESE THREE, LASTING FOR ABOUT 6 HOURS AND HITTING THE
SYSTEM IN ABOUT 30-45 MINUTES. HUMALOG IS NEWER AND ACTUALLY BEGINS WORKING IN
5-15 MINUTES AND LASTS FOR 4 HOURS

ONCE YOU UNDERSTAND THIS, YOU CAN USE INSULIN TO YOUR ADVANTAGE. WITH ALL
INSULIN YOU NEED TO HAVE GLUCOSE PRESENT IN THE BLOOD STREAM SO IT CAN HAVE
SOMETHING TO ACT ON AND TRANSPORT IT INTO THE CELLS. THE POPULAR RULE OF THUMB
OF 10-15 GRAMS OF GLUCOSE/CARBS PER I.U. OF INSULIN WAS SOMETHING THAT I
ACTUALLY CAME UP WITH. PLEASE DON'T THINK I AM BEING ARROGANT, IT'S JUST THAT
I WAS DOING A LOT OF RESEARCH ON INSULIN IN THE EARLY 90'S AND IT IS DIRECTLY
AND INDIRECTLY DUE TO THAT RESEARCH THAT INSULIN HAS BECOME A POPULAR TOOL IN
THE BODYBUILDERS ARSENAL. MANY PEOPLE HAVE CONTACTED ME ON HOW TO USE INSULIN.
NOW WITH INSULIN YOU HAVE TO REMEMBER THAT IT IS AN INDISCRIMINANT CARRIER
WHICH IS BOTH GOOD AND BAD. GOOD BECAUSE ALONG WITH THE TRANSPORTING OF
GLUCOSE, IT WILL ALSO TRANSPORT AMINO ACIDS INTO THE MUSCLE CELLS. BAD BECAUSE
IF THERE IS A LOT OF FAT PRESENT, IT WILL SHOVE THAT INTO THE CELLS AS WELL
AND THIS IS WHY YOU GET FAT FROM INSULIN. IF YOU USE A LONG ACTING INSULIN
THAT PEAKS SEVERAL TIMES THROUGHOUT THE DAY, IT IS IMPERATIVE THAT YOU EAT A
CARB AND PROTEIN MEAL EVERY 2 HOURS TO INSURE THAT WHEN IT PEAKS, YOU HAVE A
NUTRIENT POOL AVAILABLE FOR IT TO WORK ON. IF YOU TOOK A SHOT OF INSULIN IN
THE MORNING AND IT WAS LONG ACTING, IF YOU EAT A PIZZA AT 8:00PM, THE FAT WILL
GET TRANSPORTED INTO THE CELLS AND YOU WILL GET FAT. THE WAY AROUND THIS IS TO
1. KEEP DIETARY FAT TO A MINIMUM ALL THE TIME OR 2. USE A FASTER ACTING
INSULIN. FOR ME--EVEN THOUGH I ALWAYS EAT LESS THAN 30GRAMS OF FAT PER
DAY--THE ANSWER SHOULD BE 2.

THE REASON FOR THIS LIES IN THE FACT THAT YOU CAN CONTROL IT MUCH BETTER IF
YOU KNOW THAT IT IS HITTING IN 15-20MINUTES AND WILL BE OUT OF THE SYSTEM IN 4
HOURS OR LESS. ALL OF THE INCIDENTS OF PEOPLE FAINTING OR GOING INTO COMAS
BECAUSE OF INSULIN HAS TO DO WITH THE FACT THAT THERE WAS NOT ENOUGH GLUCOSE
PRESENT IN THE BLOODSTREAM WHEN THE INSULIN PEAKED. WHEN YOU USE A LONG ACTING
INSULIN THAT PEAKS AT VARIOUS TIMES OVER A 24HOUR PERIOD, YOU RUN A MUCH
GREATER RISK OF NOT HAVING ENOUGH GLUCOSE PRESENT BECAUSE YOU ARE MORE APT TO
SKIP A MEAL OR BE DRIVING IN YOUR CAR WHEN IT HITS...I LIKE THE HUMALOG THE
BEST AND WOULD TELL EVERYONE TO USE IT SOLELY OR IF THEY CANNOT GET IT, USE
THE R. DO NOT USE THE N!

DOES IT MATTER WHAT TYPES OF CARBS YOU EAT WHEN YOU USE INSULIN?

YES! I AM A FIRM BELIEVER THAT YOU SHOULD USE PRIMARILY SIMPLE CARBS.

SIMPLE CARBS?

YES. LOOK AT THE END OF THE DAY THE BODY BREAKS DOWN COMPLEX CARBS INTO
GLUCOSE AND IT IS GLUCOSE THAT IS TRANSPORTED INTO THE CELLS. WHEN YOU ARE
USING A RAPID ACTING INSULIN IT IS IMPORTANT TO MINIMIZE THE TIME IT TAKES THE
BODY TO CONVERT CARBS TO SIMPLE SUGARS. WHY CREATE ANOTHER STEP IN THE
PROCESS? IT ONLY TAKES MORE TIME AND YOU RUN THE RISK OF NOT HAVING ENOUGH OF
THE COMPLEX CARBS BROKEN DOWN INTO GLUCOSE IN TIME WHEN THE INSULIN HITS. FOR
THIS REASON I SUGGEST THE USE OF DEXTROSE.

SO WHAT IS THE REGIME YOU WOULD RECOMMEND?

WELL I SUGGEST THAT FOR OPTIMAL RESULTS, YOU USE HUMALOG AT 10-15IU'S
IMMEDIATELY AFTER TRAINING BECAUSE THAT IS WHEN YOU BODY IS MOST DEPLETED OF
GLYCOGEN STORES AND IS PRIMED TO OVERCOMPENSATE FOR THE INFLUX OF NUTRIENTS.
NOW HUMALOG HITS IN 5-15MINUTES SO YOU MUST IMMEDIATELY INGEST 10 GRAMS OF
SIMPLE CARBS PER EVERY I.U. OF INSULIN YOU USE (IN THIS CASE BETWEEN 100-150
GRAMS) I WOULD ALSO TAKE IN ADDITIONAL NUTRIENTS THAT HELP CONTRIBUTE TO
MUSCLE GROWTH SUCH AS AMINO ACIDS OR 50 GRAMS OF WHEY ISOLATE. I WOULD ALSO
HAVE 5 GRAMS OF CREATINE AT THIS TIME TO AID IN CELL VOLUMIZING.

THE BEST CASE SCENARIO WOULD BE TO DO THIS TWICE AND DAY AND THE ONLY WAY YOU
CAN DO THIS TWICE A DAY IS IF YOU TRAIN TWICE A DAY (THE MORE YOU DEPLETE YOUR
GLYCOGEN STORES, THE MORE OF AN OPPORTUNITY YOU HAVE TO USE INSULIN TO
OVERCOMPENSATE WITH NUTRIENTS)

WOULD YOU USE INSULIN DURING YOUR CONTEST PREP?

ABSOLUTELY I WOULD NOT PREPARE WITHOUT IT. YOU JUST HAVE TO KEEP IN MIND THAT
YOU HAVE TO USE IT WHEN YOU CAN IN TERMS OF HIGH CARB AND LOW CARB DAYS WHEN
YOU ARE DIETING.

SO LET ME GET THIS STRAIGHT. YOU ARE TELLING ME THAT INSULIN ALONE IS WHAT IS
RESPONSIBLE FOR THE 20-30LB. JUMP IN LEAN BODY MASS IN ALL THE TOP GUYS?

ABSOLUTELY. I GUARANTEE THAT IF A BODYBUILDER IS STAGNANT AND HAS NOT USED
INSULIN YET OR USED IT CORRECTLY, HE CAN PUT 20-30LBS OF MUSCLE ON. THERE IS
NO DOUBT IN MY MIND. I AM SO SURE OF IT THAT I WOULD BET MY LIFE ON IT. I AM
THAT POSITIVE.

ANYTHING ELSE ABOUT INSULIN WE SHOULD KNOW BEFORE WE MOVE ON?

YES. WHEN YOU USE IT, YOU WILL FIND THAT YOUR MUSCLES FILL OUT SO MUCH THAT
YOU CANNOT USE IT EVERY DAY. I FIND THAT WITH MYSELF I CAN USE IF FOR 2-3 DAYS
AND THEN OFF FOR 1-2 DAYS. EVERYONE VARIES, BUT THERE IS A POINT WHEN YOU ARE
SO SUPERSATURATED THAT YOU CANNOT GET ANY FULLER. ALSO I WOULD NOT GO OVER 40
I.U.'S OF INSULIN PER DAY DIVIDED INTO 2 20IU SHOTS. JUST SOMETHING TO KEEP IN
MIND


Insulin is insulin, but the various types will just kick in sooner or later. Humalog is the fastest, it works within minutes and lasts about 2h. Humulin kicks in in 30min but lasts 4h or so. I've used both, and prefer Humalog cause it leaves your system quicker. Humalog is more dangerous though because it kicks in a lot sooner. If you start feeling dizzy, you'll have less time to do something about it.
WHAT IS INSULIN?

Insulin is a hormone produced in the pancreas- islet cells/beta cells to be specific. Insulin facilitates the use of sugar, which all calories are ultimately converted to, for the multitude of bodily fuctions which include energy production, brain activity, metabolism regulation- basically all of your body's function either directly or indirectly.

WHERE DO I GET IT AND WHAT TYPE DO I USE?

Humilin R is available OTC just about everywhere and while it is a quick acting insulin, it is not the fastest or most consistent in terms of absorption and effect. Humilin R starts working in about 1/2 hour and the effect can last up to six hours.

Humalog is available OTC in some states/countries while be RX only in many other states. Humalog is a true fast acting insulin which begins activity within 15 minutes and ends activity within 4 hours. Humalog is the preffered insulin to use since it works more predictably and is out of your system faster which makes it easier to control.

HOW MUCH DOES IT COST?

In general, Insulin costs between $20-$30 depending on the type and where you buy it.

WHAT KIND OF NEEDLES DO I USE?

Use 29 guage, 1/2cc insulin syringes. "B-D ultra-fine" is my preference in terms of brand.

WHERE DO I INJECT?

Upper back of arm, abdomen(avoid area too close to belly button), inner and outer upper thigh, butt cheeks.

HOW DO I INJECT?

Rotate injection sites each time you inject. Don't inject into the same area two times in a row. Insulin injections are subcutaneous- not intramuscular.

WHAT DOSE DO I START WITH?

Start with 2-3 units of insulin. There is no need to start higher than this as you will be adjusting your dose gradually to find a tolerable level.

HOW DO I INCREASE MY DOSE?

To move your dose higher in order to find your ideal dose, go up by one unit per day. A very general guide would be to consider between 10 and 15 units as your pre-determined upper limit. If it turns out you want to go higher and don't have any trouble with those doses, then no harm is done and you can go higher. Don't make big leaps up in dose or assume more is better- be safe rather than sorry.

WHAT DO I EAT AND WHEN DO I EAT IT?

For Humilin R, the general start of activity is within a 1/2 hour but the varies ALOT!!!!! Don't assume you have tons of time to wait to eat simple sugars. Pay attention to how you feel and never wait more than 15 minutes(if that) to eat. First consume simple sugars(dextrose preffered but not the only one) in the form of some type of drink as these are most readily absorbed in my experience. A general guideline is 10 grams of carbs for each unit of insulin- MINIMUM! Within a hour or so after your dose you want to eat a mix of simple carbs and high protein- this is the golden hour AFTER your workout when the insulin will shuttle nutrients into your muscles very efficiently. Humilin R will peak at two hours after you take it so you must eat another balanced meal at the hour and a half mark approximately. This meal should include complex carbs, some fats, and protein. Use simple carbs also if you feel any hypoglycemic symptoms. "R" will last up to six hours so be aware of how you feel and eat as needed after the two hour mark. REMEMBER THAT YOU STILL HAVE A SIGNIFICANT AMOUNT OF INSULIN WORKING UP TO SIX HOURS LATER SO DON'T BE COMPLACENT AND ASSUME YOU'RE NOT GOING TO GO HYPOGLYCEMIC.

For Humalog, use the same general rules and type of meal sequence, but begin the process immediately. Simple carbs should be ingested within 10 minutes- NO EXCEPTIONS. Then have the carb/protein meal within the hour. Then have the balanced meal of complex carbs/fats/protein at the hour 1/2 mark. Keep aware of how you feel up to four hours after your dose and eat as needed.

FACTORS AFFECTING INSULIN ABSORPTION/SENSITIVITY

The abdomen is generally the area where insulin is absorbed the most consistently or evenly as it is designed to be.

Injections near a muscle that you have worked out can dramtically increase the absorption rate and effect of your dose of insulin.

GH will make you more insulin INsensitive so your tolerance of insulin will change when on or off of GH.

Highly androgenic steroids also make you more insulin insensitive, however, can also cause very random hypoglycemia aswell.

Supplements such as Chromium, Ginseng, Alpha Lipoic Acid, and Cinnamon (among others) increase insulin sensitivity.

Variations in glycogen levels in your muscles can also affect how severe a hypoglycemic reactions may be or may feel. If you are starting out with low levels of muscle glycogen, the same dose of insulin that didn't affect you before may now be too much.

The glucagon response from everyone's liver will vary. This hormone increases blood sugar when during stresses to the body or in response to hypoglycemia. Some people may get a big response from their liver and hypoglycemia for them won't be as severe. Others will have less of a respense and may be more prone to insulin shock. This response can also vary for each person based on their diet, exercise etc. so don't assume your liver will react the same way to hypoglycemia each time- you may get help from it or you may have to depend mostly on consuming sugar to save your life.

WHAT ARE THE SYMPTOMS OF HYPOGLYCEMIA?

They include: sweating, dizziness, heart palpitations, tremors, drowsiness, sleep distrubances, anxiety, blurred vision, hunger, restelessness, lightheadedness, tingling in extremeties, headache, slurred speech, irritability, unstable movement, personality changes, seizures, DEATH


HOW SHOULD I CYCLE INSULIN?

Insulin should be cycled so that you have less of a chance of permanently affecting your own body's production of insulin. Even cycling can affect your own production though so be aware and see your doctor regularly. I say 4 weeks on and 4 weeks off as a general rule of thumb with 6 weeks on being the absolute limit in my opinion.

----------------------------------------------------------------------------------

This was meant to be a basic introduction to using insulin. I do not condone the use of insulin by non-diabetics nor am I encouraging anyone to use insulin. I am not a doctor and YOU are the only one who can be responsible for making the decision to use insulin. I hope this helps someone to stay safe and think things through before jumping into the unknown. I will be adding things to this as I go since I'm sure I forgot some things.
How to use insulin - the most anabolic hormone

This was originally posted on AF by Juice Junkie.


Directions for first time insulin users

This is an article I wrote a little while ago and posted on several boards. I know its a long post but take the time and read it because your life does in fact depend on it. There are a couple other articles on the Anabolic Review board in the Hot Topics Section but I think they all pretty much have the same info.

Let me know if you have any questions

Insulin is the most anabolic hormone you can take. On the other hand its also one of the most dangerous for two reasons availability and ignorance. I will be the first to tell you that every time I have been hypoglycemic (when blood sugar drops to dangerous levels) its has been as a result of something I did wrong. Used responsibility and with respect for the potential sides it is quite safe and extremely effective. That being said we'll start off with what you are going to need.

Equipment:
There are several types of insulin out there but for our purposes we are only interested in two. The first being my favorite Humulin R and the other being a bit newer to the body building community Humalog.

Humulin R is the most widely used and time tested insulin in our arsenal. It has a max duration of 4hrs and its peak can been seen around 2hrs after injection. This becomes particularly important when planning out you meals for the day so keep the timetables in mind.

Humalog is a bit newer but some feel just as effective and a bit safer. Humalog has a max duration of 2hrs and its peak can be seen around 1hr after injection. When selecting to use one or the other keep in mind your schedule, meals, and physical activity for the day as it will all play a role. One other point that needs mentioning is that Humulin R is available over the counter at pretty much every pharmacy in the country for about $25 for 10ml (which will last you a very long time) and Humalog is available only through a prescription or over the black market for a price about double that of Humulin R. When approaching a pharmacist keep in mind that its a lot more convincing if you buy the needles at the same time you get the insulin. This way they are less likely to refuse to sell it to you which they have been known to do from time to time. If this should happen just continue on to the next pharmacy and despite what they tell you "you dont need a prescription" it might be their store policy to see one but legally it is not required and if you make enough of a fuss you will get what you need.

The next thing you will need is the actual needles for injection. These are not the same type that you would use for anabolics or other androgens. The type of needles you will need are U100 insulin needles. That is exactly what you need to say when are trying to buy them. A box of 100 will usually run about $15-$25 and again will last you quite a while. Be fore warned now, using a syringe labeled with cc/ml or anything other than u100 is potentially fatal. The difference between the amount of insulin used for our purpose and that which will kill you is less than 1/2 a cc.

The next two things I think you will need and I highly recommend having on you is a wrist watch with a chronograph (stopwatch) and glucose tabs and/or a can of soda. First I'll explain the wrist watch. The stop watch is to be started immediately after the injection and monitored periodically to keep track of what is in your body and how long it is active. This can also be used to determine whether or not you are feeling side effects or simply just nerves from the fear that follows using for the first time. For instance I always use Humulin R which we know has a duration of 4 hours and a peak at 2 hours. This means that the greatest effects will be felt somewhere between 1-1/2 to 2 hours after injection and then they will steadily lessen till it is no longer active 4 hours after injection. When you use a stopwatch you have an accurate record of when you felt the effects which will become more important as you get more experienced using insulin. The glucose tabs are your safety net. If you are feeling hypo (hypoglycemic) these tabs will return your blood sugar levels to a safe range where you can get some food. They are available at all pharmacies for about $1.00. I have also used a soda. Soda is high in simple carbs which act quickly when blood sugar is low and allow you to get to a safe range where you can get some food in you. Now that we've covered all the equipment needed to safely use insulin we'll move on to dosage diet and scheduling.

Dosage diet and scheduling:
Whenever you start insulin its always wise to start at a lower dose and taper up over the first couple of days of use. Insulin is still new in our community and there is a potential for becoming diabetic so dont take chances start small more is not better where insulin is concerned more is simply more fat and more dangerous. This is a schedule I use when just starting insulin:

day1: 5iu's post workout
day2: 6iu's post workout
day3: 7iu's post workout
day4: 8iu's post workout
day5: 9iu's post workout
day6: 10iu's post workout
day7: same as day 6

This concludes week once from here on out this is how I proceed. If I am going to be increasing my dose even further.

day8-10: 10iu's morning, 10iu's post workout
day11-14: 10iu's morning, 10iu's noon, 10iu's post workout
day15 and on: increase post workout dose till I start to feel symptoms of hypoglycemia and then back the dose down accordingly. THIS IS ONLY FOR ADVANCED USERS, DONT EXCEED THE DAY 7 DOSE TILL YOU GET SOME TIME UNDER YOUR BELT. I AM NOT KIDDING YOU WILL DIE!!!

Your diet will depend on the amount of slin you take per injection. The rule is 10 grams of carbs per IU of insulin. Therefore if you take 10iu's at an injection you need 100 grams of carbs. This is a bit overkill the actual figure is about 5-7 grams but its best to stick with the 10 rule while starting out. I feel that the best most accurate way to consume the proper amount of carbs after an injection is through MRP's or other shakes. The amounts of carbs on these are far more accurate than those you will find on the back of a bread bag. My meals are usually layed out like this:

7am: 10iu's insulin, shake
9am: shake
12pm: 10iu's insulin, lunch
2pm: shake
4pm: shake
6pm: workout
7pm: 10iu's insulin, shake, higher in carbs than others
9pm: dinner
11pm: safe for bed

If you'll notice there is a method to the madness above. After taking your first injection if insulin you will need a shake immediately. After this you are good for the next 2 hrs till the insulin peaks. Once you hit the 2hr mark you will need more carbs either another shake or a meal with sufficient carbs. After you have cleared the 4hr mark you will be clear from danger. Now this is all based on using Humulin R. If you are using Humalog you will need to take your first meal after injection and another "1hr" after. Then after the 2hr mark you will be safe. My shakes are made up of 1/2 pack of MetRX (berry) and 2 scoops GNC brand weight gainer (vanilla) and 16oz of whole milk. This shake has a caloric value of about 800 cals and around 50grams of protein and 150+grams of carbs. This is a good meal for those starting out. As you progress though you will want to decrease the carbs and eliminate the fat completely to maximize lean mass gains and minimize water and fat retention but for the purposes of starting out simply taking T3 will offset any fat gained. One thing to keep in mind is that T3 will reduce your sensitivity to insulin allowing you to take a higher dose but again save this till you get some more time in.

Side effects and procedures:
After injection and starting your stopwatch your first task is to get some carbs in. Next the first sides you will feel is tired. This is normal and is to be expected. You will usually feel this somewhere between 15-30 minutes after your injection. The key here is not to sleep, if you sleep you wont feel further more dangerous sides and therefore you wont be able to save your ass. The next thing you need to do is have another meal/shake at the 2hr mark. If you miss this just get it in as soon as possible. If you delay long enough you will start to feel hypo around 3 to 3-1/2 hours after injection. When this happens you will feel a sort of numbness that I can only relate to ephedrine. After this you will start to get some shakes in your hands followed by a cold sweat. Once you get to this point you are full blown hypo, the next thing that will follow will be a bit of tunnel vision and this is as far as Iíve been after this its all textbook I imagine coma will follow shortly after passing out. When you get the symptoms listed above donít hesitate. Get some soda/glucose tabs followed by a meal or shake. One other fact I neglected to mention is that a mix of carbs is necessary when consuming a meal. Simple carbs are used to quickly and complex donít kick in fast enough. A good mix is the way to go.

This is pretty much a beginners guide to getting started on insulin. If you have any questions either post them on the board or email me. No question is stupid when it comes to a potentially fatal drug. Good luck and get huge.
__________________

Disclaimer:
gonnabebig is presenting fictitious opinions and does in no way, shape or form encourage, use nor condone the use of any illegal substances or the use of legal substances in an illegal manner. The information discussed is strictly for entertainment purposes only and shall not take the place of qualified medical advice.
How to use insulin - the most anabolic hormone

This was originally posted on AF by Juice Junkie.


Directions for first time insulin users

This is an article I wrote a little while ago and posted on several boards. I know its a long post but take the time and read it because your life does in fact depend on it. There are a couple other articles on the Anabolic Review board in the Hot Topics Section but I think they all pretty much have the same info.

Let me know if you have any questions

Insulin is the most anabolic hormone you can take. On the other hand its also one of the most dangerous for two reasons availability and ignorance. I will be the first to tell you that every time I have been hypoglycemic (when blood sugar drops to dangerous levels) its has been as a result of something I did wrong. Used responsibility and with respect for the potential sides it is quite safe and extremely effective. That being said we'll start off with what you are going to need.

Equipment:
There are several types of insulin out there but for our purposes we are only interested in two. The first being my favorite Humulin R and the other being a bit newer to the body building community Humalog.

Humulin R is the most widely used and time tested insulin in our arsenal. It has a max duration of 4hrs and its peak can been seen around 2hrs after injection. This becomes particularly important when planning out you meals for the day so keep the timetables in mind.

Humalog is a bit newer but some feel just as effective and a bit safer. Humalog has a max duration of 2hrs and its peak can be seen around 1hr after injection. When selecting to use one or the other keep in mind your schedule, meals, and physical activity for the day as it will all play a role. One other point that needs mentioning is that Humulin R is available over the counter at pretty much every pharmacy in the country for about $25 for 10ml (which will last you a very long time) and Humalog is available only through a prescription or over the black market for a price about double that of Humulin R. When approaching a pharmacist keep in mind that its a lot more convincing if you buy the needles at the same time you get the insulin. This way they are less likely to refuse to sell it to you which they have been known to do from time to time. If this should happen just continue on to the next pharmacy and despite what they tell you "you dont need a prescription" it might be their store policy to see one but legally it is not required and if you make enough of a fuss you will get what you need.

The next thing you will need is the actual needles for injection. These are not the same type that you would use for anabolics or other androgens. The type of needles you will need are U100 insulin needles. That is exactly what you need to say when are trying to buy them. A box of 100 will usually run about $15-$25 and again will last you quite a while. Be fore warned now, using a syringe labeled with cc/ml or anything other than u100 is potentially fatal. The difference between the amount of insulin used for our purpose and that which will kill you is less than 1/2 a cc.



The next two things I think you will need and I highly recommend having on you is a wrist watch with a chronograph (stopwatch) and glucose tabs and/or a can of soda. First I'll explain the wrist watch. The stop watch is to be started immediately after the injection and monitored periodically to keep track of what is in your body and how long it is active. This can also be used to determine whether or not you are feeling side effects or simply just nerves from the fear that follows using for the first time. For instance I always use Humulin R which we know has a duration of 4 hours and a peak at 2 hours. This means that the greatest effects will be felt somewhere between 1-1/2 to 2 hours after injection and then they will steadily lessen till it is no longer active 4 hours after injection. When you use a stopwatch you have an accurate record of when you felt the effects which will become more important as you get more experienced using insulin. The glucose tabs are your safety net. If you are feeling hypo (hypoglycemic) these tabs will return your blood sugar levels to a safe range where you can get some food. They are available at all pharmacies for about $1.00. I have also used a soda. Soda is high in simple carbs which act quickly when blood sugar is low and allow you to get to a safe range where you can get some food in you. Now that we've covered all the equipment needed to safely use insulin we'll move on to dosage diet and scheduling.

Dosage diet and scheduling:
Whenever you start insulin its always wise to start at a lower dose and taper up over the first couple of days of use. Insulin is still new in our community and there is a potential for becoming diabetic so dont take chances start small more is not better where insulin is concerned more is simply more fat and more dangerous. This is a schedule I use when just starting insulin:

day1: 5iu's post workout
day2: 6iu's post workout
day3: 7iu's post workout
day4: 8iu's post workout
day5: 9iu's post workout
day6: 10iu's post workout
day7: same as day 6

This concludes week once from here on out this is how I proceed. If I am going to be increasing my dose even further.

day8-10: 10iu's morning, 10iu's post workout
day11-14: 10iu's morning, 10iu's noon, 10iu's post workout
day15 and on: increase post workout dose till I start to feel symptoms of hypoglycemia and then back the dose down accordingly. THIS IS ONLY FOR ADVANCED USERS, DONT EXCEED THE DAY 7 DOSE TILL YOU GET SOME TIME UNDER YOUR BELT. I AM NOT KIDDING YOU WILL DIE!!!

Your diet will depend on the amount of slin you take per injection. The rule is 10 grams of carbs per IU of insulin. Therefore if you take 10iu's at an injection you need 100 grams of carbs. This is a bit overkill the actual figure is about 5-7 grams but its best to stick with the 10 rule while starting out. I feel that the best most accurate way to consume the proper amount of carbs after an injection is through MRP's or other shakes. The amounts of carbs on these are far more accurate than those you will find on the back of a bread bag. My meals are usually layed out like this:

7am: 10iu's insulin, shake
9am: shake
12pm: 10iu's insulin, lunch
2pm: shake
4pm: shake
6pm: workout
7pm: 10iu's insulin, shake, higher in carbs than others
9pm: dinner
11pm: safe for bed

If you'll notice there is a method to the madness above. After taking your first injection if insulin you will need a shake immediately. After this you are good for the next 2 hrs till the insulin peaks. Once you hit the 2hr mark you will need more carbs either another shake or a meal with sufficient carbs. After you have cleared the 4hr mark you will be clear from danger. Now this is all based on using Humulin R. If you are using Humalog you will need to take your first meal after injection and another "1hr" after. Then after the 2hr mark you will be safe. My shakes are made up of 1/2 pack of MetRX (berry) and 2 scoops GNC brand weight gainer (vanilla) and 16oz of whole milk. This shake has a caloric value of about 800 cals and around 50grams of protein and 150+grams of carbs. This is a good meal for those starting out. As you progress though you will want to decrease the carbs and eliminate the fat completely to maximize lean mass gains and minimize water and fat retention but for the purposes of starting out simply taking T3 will offset any fat gained. One thing to keep in mind is that T3 will reduce your sensitivity to insulin allowing you to take a higher dose but again save this till you get some more time in.

Side effects and procedures:
After injection and starting your stopwatch your first task is to get some carbs in. Next the first sides you will feel is tired. This is normal and is to be expected. You will usually feel this somewhere between 15-30 minutes after your injection. The key here is not to sleep, if you sleep you wont feel further more dangerous sides and therefore you wont be able to save your ass. The next thing you need to do is have another meal/shake at the 2hr mark. If you miss this just get it in as soon as possible. If you delay long enough you will start to feel hypo around 3 to 3-1/2 hours after injection. When this happens you will feel a sort of numbness that I can only relate to ephedrine. After this you will start to get some shakes in your hands followed by a cold sweat. Once you get to this point you are full blown hypo, the next thing that will follow will be a bit of tunnel vision and this is as far as Iíve been after this its all textbook I imagine coma will follow shortly after passing out. When you get the symptoms listed above donít hesitate. Get some soda/glucose tabs followed by a meal or shake. One other fact I neglected to mention is that a mix of carbs is necessary when consuming a meal. Simple carbs are used to quickly and complex donít kick in fast enough. A good mix is the way to go.

This is pretty much a beginners guide to getting started on insulin. If you have any questions either post them on the board or email me. No question is stupid when it comes to a potentially fatal drug. Good luck and get huge.
__________________

Disclaimer:
gonnabebig is presenting fictitious opinions and does in no way, shape or form encourage, use nor condone the use of any illegal substances or the use of legal substances in an illegal manner. The information discussed is strictly for entertainment purposes only and shall not take the place of qualified medical advice.
How to use insulin - the most anabolic hormone

This was originally posted on AF by Juice Junkie.


Directions for first time insulin users

This is an article I wrote a little while ago and posted on several boards. I know its a long post but take the time and read it because your life does in fact depend on it. There are a couple other articles on the Anabolic Review board in the Hot Topics Section but I think they all pretty much have the same info.

Let me know if you have any questions

Insulin is the most anabolic hormone you can take. On the other hand its also one of the most dangerous for two reasons availability and ignorance. I will be the first to tell you that every time I have been hypoglycemic (when blood sugar drops to dangerous levels) its has been as a result of something I did wrong. Used responsibility and with respect for the potential sides it is quite safe and extremely effective. That being said we'll start off with what you are going to need.

Equipment:
There are several types of insulin out there but for our purposes we are only interested in two. The first being my favorite Humulin R and the other being a bit newer to the body building community Humalog.

Humulin R is the most widely used and time tested insulin in our arsenal. It has a max duration of 4hrs and its peak can been seen around 2hrs after injection. This becomes particularly important when planning out you meals for the day so keep the timetables in mind.

Humalog is a bit newer but some feel just as effective and a bit safer. Humalog has a max duration of 2hrs and its peak can be seen around 1hr after injection. When selecting to use one or the other keep in mind your schedule, meals, and physical activity for the day as it will all play a role. One other point that needs mentioning is that Humulin R is available over the counter at pretty much every pharmacy in the country for about $25 for 10ml (which will last you a very long time) and Humalog is available only through a prescription or over the black market for a price about double that of Humulin R. When approaching a pharmacist keep in mind that its a lot more convincing if you buy the needles at the same time you get the insulin. This way they are less likely to refuse to sell it to you which they have been known to do from time to time. If this should happen just continue on to the next pharmacy and despite what they tell you "you dont need a prescription" it might be their store policy to see one but legally it is not required and if you make enough of a fuss you will get what you need.

The next thing you will need is the actual needles for injection. These are not the same type that you would use for anabolics or other androgens. The type of needles you will need are U100 insulin needles. That is exactly what you need to say when are trying to buy them. A box of 100 will usually run about $15-$25 and again will last you quite a while. Be fore warned now, using a syringe labeled with cc/ml or anything other than u100 is potentially fatal. The difference between the amount of insulin used for our purpose and that which will kill you is less than 1/2 a cc.

The next two things I think you will need and I highly recommend having on you is a wrist watch with a chronograph (stopwatch) and glucose tabs and/or a can of soda. First I'll explain the wrist watch. The stop watch is to be started immediately after the injection and monitored periodically to keep track of what is in your body and how long it is active. This can also be used to determine whether or not you are feeling side effects or simply just nerves from the fear that follows using for the first time. For instance I always use Humulin R which we know has a duration of 4 hours and a peak at 2 hours. This means that the greatest effects will be felt somewhere between 1-1/2 to 2 hours after injection and then they will steadily lessen till it is no longer active 4 hours after injection. When you use a stopwatch you have an accurate record of when you felt the effects which will become more important as you get more experienced using insulin. The glucose tabs are your safety net. If you are feeling hypo (hypoglycemic) these tabs will return your blood sugar levels to a safe range where you can get some food. They are available at all pharmacies for about $1.00. I have also used a soda. Soda is high in simple carbs which act quickly when blood sugar is low and allow you to get to a safe range where you can get some food in you. Now that we've covered all the equipment needed to safely use insulin we'll move on to dosage diet and scheduling.

Dosage diet and scheduling:
Whenever you start insulin its always wise to start at a lower dose and taper up over the first couple of days of use. Insulin is still new in our community and there is a potential for becoming diabetic so dont take chances start small more is not better where insulin is concerned more is simply more fat and more dangerous. This is a schedule I use when just starting insulin:

day1: 5iu's post workout
day2: 6iu's post workout
day3: 7iu's post workout
day4: 8iu's post workout
day5: 9iu's post workout
day6: 10iu's post workout
day7: same as day 6

This concludes week once from here on out this is how I proceed. If I am going to be increasing my dose even further.

day8-10: 10iu's morning, 10iu's post workout
day11-14: 10iu's morning, 10iu's noon, 10iu's post workout
day15 and on: increase post workout dose till I start to feel symptoms of hypoglycemia and then back the dose down accordingly. THIS IS ONLY FOR ADVANCED USERS, DONT EXCEED THE DAY 7 DOSE TILL YOU GET SOME TIME UNDER YOUR BELT. I AM NOT KIDDING YOU WILL DIE!!!

Your diet will depend on the amount of slin you take per injection. The rule is 10 grams of carbs per IU of insulin. Therefore if you take 10iu's at an injection you need 100 grams of carbs. This is a bit overkill the actual figure is about 5-7 grams but its best to stick with the 10 rule while starting out. I feel that the best most accurate way to consume the proper amount of carbs after an injection is through MRP's or other shakes. The amounts of carbs on these are far more accurate than those you will find on the back of a bread bag. My meals are usually layed out like this:

7am: 10iu's insulin, shake
9am: shake
12pm: 10iu's insulin, lunch
2pm: shake
4pm: shake
6pm: workout
7pm: 10iu's insulin, shake, higher in carbs than others
9pm: dinner
11pm: safe for bed

If you'll notice there is a method to the madness above. After taking your first injection if insulin you will need a shake immediately. After this you are good for the next 2 hrs till the insulin peaks. Once you hit the 2hr mark you will need more carbs either another shake or a meal with sufficient carbs. After you have cleared the 4hr mark you will be clear from danger. Now this is all based on using Humulin R. If you are using Humalog you will need to take your first meal after injection and another "1hr" after. Then after the 2hr mark you will be safe. My shakes are made up of 1/2 pack of MetRX (berry) and 2 scoops GNC brand weight gainer (vanilla) and 16oz of whole milk. This shake has a caloric value of about 800 cals and around 50grams of protein and 150+grams of carbs. This is a good meal for those starting out. As you progress though you will want to decrease the carbs and eliminate the fat completely to maximize lean mass gains and minimize water and fat retention but for the purposes of starting out simply taking T3 will offset any fat gained. One thing to keep in mind is that T3 will reduce your sensitivity to insulin allowing you to take a higher dose but again save this till you get some more time in.

Side effects and procedures:
After injection and starting your stopwatch your first task is to get some carbs in. Next the first sides you will feel is tired. This is normal and is to be expected. You will usually feel this somewhere between 15-30 minutes after your injection. The key here is not to sleep, if you sleep you wont feel further more dangerous sides and therefore you wont be able to save your ass. The next thing you need to do is have another meal/shake at the 2hr mark. If you miss this just get it in as soon as possible. If you delay long enough you will start to feel hypo around 3 to 3-1/2 hours after injection. When this happens you will feel a sort of numbness that I can only relate to ephedrine. After this you will start to get some shakes in your hands followed by a cold sweat. Once you get to this point you are full blown hypo, the next thing that will follow will be a bit of tunnel vision and this is as far as Iíve been after this its all textbook I imagine coma will follow shortly after passing out. When you get the symptoms listed above donít hesitate. Get some soda/glucose tabs followed by a meal or shake. One other fact I neglected to mention is that a mix of carbs is necessary when consuming a meal. Simple carbs are used to quickly and complex donít kick in fast enough. A good mix is the way to go.

This is pretty much a beginners guide to getting started on insulin. If you have any questions either post them on the board or email me. No question is stupid when it comes to a potentially fatal drug. Good luck and get huge.
__________________

Disclaimer:
gonnabebig is presenting fictitious opinions and does in no way, shape or form encourage, use nor condone the use of any illegal substances or the use of legal substances in an illegal manner. The information discussed is strictly for entertainment purposes only and shall not take the place of qualified medical advice.
Insulin FAQ
I do not know the origin, but this has been passed around quite a few times.

THE SKINNY ON INSULIN
There has been increasing popularity, and curiosity, concerning exogenous use of "the most anabolic hormone in the body". This makes it necessary to inform people how to maximise muscle mass acquisition and minimise horrid body fat accumulation when using it. The following is a detailed description of the effects of exogenous insulin use, combined with several other common bodybuilding drugs, from a muscle anabolism and fat catabolism point of view.
*WARNING*
Morons and bodybuilding novices should not consider insulin use, because it has one of the highest potentials for danger of all bodybuilding drugs. Its' use requires complete discipline and control over ones' environment. Insulin misuse should not be taken lightly because death's from it occur almost weekly. If that doesn't scare you, consider this: it can make you very, VERY, fat.
Before we delve in to the insulin alchemy, we should understand why insulin does such a good job of muscle and fat accumulation. Of course insulin is known as "the storage hormone", which means that it stores various macronutrients in different body tissues. Protein storage comes directly from amino acid uptake and protein synthesis in skeletal muscle. This is what we want. Fat storage comes from: directly reducing fat release from fat cells (adipocytes), increasing the rate at which the other macronutrients are converted in to fat, and inducing fat storage. This is what we don't want. Carbohydrate storage also occurs, but only significantly in special circumstances (discussed later). Now the fun part.
INSULIN AND ANABOLIC STEROIDS
Of course when everyone thinks of bodybuilding drugs anabolic steroids (AS) are the first things to come to mind, but how do they work with insulin? VERY WELL! AS decrease insulin induced fat accumulation through a number of ways. One is through creatine synthetase, which is an enzyme that goes crazy after workouts trying to store carbohydrates in the muscles (as glycogen, creatine phosphate etc.). For every gram of carbohydrate stored in muscle, roughly four grams of water go along with it (this is how creatine monohydrate achieves such dramatic results). How does this relate to insulin and AS? Well, the "harder" AS (exemplified by oxymethelone) increase creatine synthetase levels dramatically, giving insulin a place to do its' job and store carbohydrates. Okay, this also counts for a combined anabolic effect, but it prevents insulin from converting any "excess" carbohydrate in to fat (which would subsequently be stored)! AS also decrease levels of the main fat storage enzyme that insulin increases (called lipoprotein lipase). A big effect is through glucocorticoid antagonism, which means that AS indirectly increase insulin sensitivity (as well as act anti-catabolically). This allows insulin to bind to its' receptors more easily and accomplish its' job rather, than converting more macronutrients in to fat. Finally, the demand for nutrients by muscles is so high, in an AS enhanced state, that there is rarely any excess of nutrients to actually be stored as fat! A mere 400 mgs of enanthate didn't allow me to accumulate fat whether I was using insulin or not.



From a muscular anabolic perspective, there is a synergistic effect between AS and insulin. This is because they both directly stimulate protein synthesis as well as other mechanisms. One such mechanism involves AS hepatic mediated somatomedin release. Simply put: IGF-1 production in the liver. Again, the more powerful the AS, the more IGF-1 release, with orals having a much greater effect than injectables. Insulin increases the duration of time that IGF-1 is active in the bloodstream, and enhances receptor mediated IGF-1 activity (all through enhancing specific IGF-1 binding proteins). Another great combined effect is that insulin reduces the amount of Sex Hormone Binding Proteins (SHBP) in the blood stream. This allows more AS to be active and do their job of making you grow! Great effects were seen while using 10 units of insulin only three times a week, with AS. For the first few weeks of my next cycle I'm not going off the stuff, and I expect the effects to be scary!
INSULIN AND THE C/A/E STACK
In case you've been living on Mars for the past few years, CAE stands for Caffeine, Aspirin, and Ephedrine. This stack has been shown to synergistically strip off fat, while preserving muscle mass. It is considered here because it is the minimum requirement, while using insulin, to prevent you from looking like the StayPuft marshmallow man. Also of benefit is that it is cheap and easily accessible. Using three times a day helps slow the fat accumulation, but strict dietary control is also necessary. The ephedrine: suppresses appetite, stimulates thermogenesis, and promotes and fat release from cells (beta receptor, and catecholamine, mediated), while the other two components of the stack increase thermogenesis by inhibiting certain enzymes and transmitters that try to slow down the thermic effect. Ultimately the appetite suppression effectiveness of ephedrine wears off, but this is replaced by a greater thermogenic effect (5-deiodinase, or Beta-3, mediated). The CAE stack does nothing for muscle anabolism in a hyper caloric situation, but that's what the insulin is for.
INSULIN AND CLENBUTEROL
This "soon to be classic" post-cycle stack not only increases muscle mass, but keeps fat off at the same time. Fat loss from clen is legendary for the first two weeks. After that time, the beta-2 receptors that it activates, attenuate (because of the extremely high binding specificity), dropping the fat burning effects to minimal levels. There should still be beta-1 receptor activation (which stimulates fat release from adipocytes) and beta-3 stimulation (the big thermogenic wonders), because they attenuate slower or not at all (respectively) compared to beta-2 receptors. Clen is a much better fat burner than ephedrine, due not only to its' higher receptor specificity, but also due to it's extremely long half life (the exact reason it's not approved for use in humans). This means that the drug is constantly burning fat, especially at night when serum glucose, and insulin, are low. Using aspirin and caffeine might slow the receptor attenuation, or at least increase the thermogenesis while its there (I can certainly attest to this!). Why hasn't anyone done this sooner? Clen, like AS, directly combats the fat storing enzyme that insulin promotes (lipoprotein lipase again) in white fat. However it actually increases this enzymatic activity in brown fat (hence the thermogenesis) and muscle. The latter event could promote muscle anabolism through a similar mechanism to HMB, or at least increases muscular fat storage (merely increasing muscle size). This may not seem significant, but the way that people are going nuts over synthol, you never know! The mechanism of action of clens' muscle building effect is not known, but it appears to be anti-catabolic rather than directly anabolic. It should be noted that this anticatabolism is not beta receptor mediated , and therefore does not attenuate. At any rate, the combined effect of the two drugs can be noticeable muscle gain while keeping fat off for the first two weeks. Can fat accumulation be slowed with this stack continue past this time? I'll let you know!
THE SKINNY ON INSULIN: PART II
There has been increasing popularity, and curiosity, concerning exogenous use of "the most anabolic hormone in the body". This makes it necessary to inform people how to maximize muscle mass acquisition and minimize nasty body fat accumulation when using it. The following is the second article dealing with the effects of exogenous insulin use, combined with several other bodybuilding drugs and supplements, from a muscle anabolism and fat catabolism point of view. Part I outlined insulin use combined with: anabolic steroids, the C/A/E stack, and clenbuterol.
*WARNING*
Insulin has one of the highest potentials for danger of all bodybuilding drugs. It shouldn't be screwed around with.
INSULIN AND GROWTH HORMONE
Growth hormone (GH) is one of the most sought after bodybuilding drugs due to its' legendary abilities to strip off body fat and increase muscle mass. The former is accomplished through direct lipolysis (fat release from adipocytes), which GH does to an incredible degree. Muscle mass acquisition is accomplished through: the direct stimulation of protein synthesis, increasing amino acid uptake by muscle cells, and by greatly stimulating IGF-1 synthesis in the liver. It is this last point that is of interest to us because it is the main anabolic mechanism for GH, and it is also where insulin comes in to play. More than half of GHs' anabolic effect is due to IGF-1 production, but unfortunately this is quite often wasted. This is because IGF-1 has an extremely short half life in the bloodstream, so it usually doesn't reach many target tissues (muscles for our interest) to exert maximum anabolic effect. To rectify this situation, insulin can be used to increase the amount of an IGF-1 binding protein (specifically IGF1-BP3) that actually helps IGF-1 to reach the muscles and exert its' extreme anabolism. Insulin also reduces the amount of "bad" IGF1 BP's, (BP's 2 and 4) that would normally interfere with IGF-1 uptake and use by muscle. To say that there is a synergistic effect between insulin and GH doesn't do the combination justice. It makes me shudder to think of the hundreds of thousands of dollars spent on GH, without using it to the maximum anabolic potential. From a fat loss perspective, GH is incredible. It should directly negate the lipogenic effect of insulin, leaving you with one KICK ASS combination.
INSULIN AND THYROID HORMONES
With the huge increases in fat mass often accompanying insulin use, it seems like a simple solution to use thyroid hormone. Unfortunately, this doesn't work out very well. The reason is that thyroid hormone (specifically T3 and possibly T4) increases the amount of the "bad" IGF1-BP's mentioned earlier;IGFBP2 and IGFBP4. This may not seem like a big deal if one is not using drugs to stimulate IGF-1 synthesis, but IGF-1 levels are naturally stimulated through acts like stretching, and even natural testosterone/GH increases. All of these things normally accompany workouts (if you know what you're doing), which is the best time to take insulin. So by having all of the free IGF-1 bound by IGFBP3s' evil siblings, much of the anabolic effect of insulin is lost! Since T3 (triiodothyronine) is the main culprit, does that mean that T4 (tetraiodothyronine) can be used with no detrimental effect? NO, because T4 is mostly effective by converting to T3, which leaves you with the same problem. In fact, T4 could very well do the same thing. So if you want to maximize the anabolic effectiveness of insulin while minimizing bodyfat accumulation, use another fat burner and leave the thyroid alone.
INSULIN AND CREATINE
These compounds may have an anti-synergistic effect on each other, meaning that the combined effect is less than the sum of the individual effects. This possibility exists due to both components' ability to store water in muscle cells. If only a certain amount of water can be stored in the cells through each mechanism of action, then the anti-synergistic condition would exist. Although this condition is unlikely, it is worth mentioning for future experimentation purposes (lab rats know where to contact me). One definite advantage of this combination is that creatine is best absorbed by the muscles when insulin serum levels are high, insuring maximum effectiveness. BTW-if one is not doing something as fundamental as using creatine, there is no way they should be using insulin (so basically insulin use requires creatine use).
INSULIN AND HCA
Getting straight to the point, unless you are a moron and are eating fat during insulin use, or you have crappy insulin sensitivity, HCA is the second most effective fat gain inhibitor next to clenbuterol (which is only more effective due to its' ridiculously long half life). Hydroxy Citric Acid (HCA) is the main ingredient in Citrimax, and is a bargain in terms of its': relative effectiveness (when using insulin), cost (cheap, cheap, cheap), and availability. It works by inhibiting an enzyme called ATP citrate ly(s)ase (ACL), which basically converts ingested carbs to fat (which insulin promptly stores). This is normally NOT a big deal since ACL levels are normally low in most humans. However, insulin drastically increases ACL levels (which should make sense based on what you now know about insulin) accounting for most of the, responsible use, fat gain associated with insulin use. This is the most exciting find since the discovery of insulin as an anabolic! Using insulin and not gaining fat while gaining muscle? What a concept! Although I don't like to go into the details of use directly, I believe it is warranted here. 500-750mgs HCA should be taken with or within half an hour after the insulin shot. The usually recommended 250mgs is ineffective in dealing with the drastic increase in ACL levels. The HCA is taken with the shot because both start to work on about one half hour, so the HCA can begin to be effective at the same time that insulin is trying to increase ACL levels. This regimen (only 3X500mgs HCA) prevented fat gain during a day when I used 3 separate insulin shots! To make things even better there is a mild glycogen storage property associated with HCA use. Since ingested carbs cannot be converted to, or stored as, fat, they are generally stored (due to insulin) as glycogen in muscle giving the user a mild but noticeable pump (similar to the first day of creatine use). To end this portion of the list, I give HCA my highest recommendation as the number 1 supplement to use with insulin!
INSULIN AND FLAX SEED OIL
Short and sweet. Don't use flax seed oil with insulin, because it is fat and *will* be stored. The fat storage rules totally change when insulin is involved (I even avoid vitamin E capsules because mine are oil based).
INSULIN AND CLENBUTEROL UPDATE
This may look like an ideal combination at first, but research has shown why my muscle gains with this combo were minimal. Clen reduces insulin sensitivity, which means that insulin will have a much harder time doing its' anabolic job on muscle tissue. In addition to storing amino acids as muscle, insulin also stores carbs in muscle (which gives a very "full" look to the muscles), which reduced insulin sensitivity also hinders. This is also combined with the fact that clen reduces Glut-4 transporters (which allow glucose passage, and subsequent storage, into muscle) in skeletal muscle which probably accounts for clens' ability to reduce muscle glycogen concentration. On a lighter note, the fat burning effects of clen are potentiated by aspirin and caffeine (through personal experience) but still die off after a few weeks. Overall the only time I would recommend this combination occurs when coming off a cycle and every bit of anabolism is needed, otherwise the two drugs have a bad effect (from an anabolic standpoint) on each other.
SIMPLE TIPS TO MAXIMIZE ANABOLISM AND MINIMIZE FAT GAIN WITH INSULIN USE
-USE HCA
- use testosterone enhancing compounds to increase hepatic IGF-1 production
- only use insulin first thing in the morning or during/after workouts
- don't consume *any* fat 2 hours before (due to digestion time) or one hour after (due to induced enzyme activity) insulin use
- stretch to locally increase IGF-1 levels
- continually eat protein spread over the 4-5 hour duration of insulin activity
Finally, my favourite tip from Docroid: (I) use one shot of insulin just before a one hour workout and another shot two hours after the first. This creates synergism between the activity of the two shots by the later shot increasing in activity at the same time as the first shot decreases in activity, giving one a steady high insulin level at the most important time for anabolism! The only time I can say that I have seen dramatic results from insulin use (in terms of muscle anabolism) occurs when I do this "technique". HOWEVER, this is *very* tricky, in terms of serum glucose levels, even for seasoned insulin users. After using for a while, one can get used to the "feel" of insulin, blood sugar crashes, feeding times etc. but things change when one has a high level of insulin for 3-4 hours straight. I've had to eat every hour for three hours during one of my first attempts at this technique, but every two hours some other attempts. This is the only time I don't feel secure with my own insulin use. It's actually a good thing I can now recognize what a blood sugar crash feels like or I'd probably be dead due to this technique. I don't recommend this technique to anyone (and if that's not a big deal to you, just remember who is writing this) but if you feel like using it, make sure that you have had a couple of, (horrible) insulin induced, serum glucose crashes so you can recognize the early warning signs for when you have them (and you *will* have them).
THE SKINNY ON INSULIN: PART III
*WARNING*: Insulin is not a drug to be taken lightly. It's use can harm or even kill an ignorant user. If you plan on using, educate yourself and at least read the last part of this article.
INSULIN AND ANDROSTENDIONE
This combo has potential due to the interesting ability of insulin to increase levels of 17B hydroxysteroid dehydrogenase(17B), which is the enzyme that converts andro. into testosterone. If the increase is anything near the 17B levels that women have, this could become the stack for "natural" Ōbodybuilders. Another possible benefit of this stack is the idea that insulin probably exhibits mild anti-aromatase properties. If this occurs to any significant level it could be great in increasing the 17B levels even more! Although I hate to rain on this theory parade, I have to say that I can't notice ANY anti-aromatase activity from insulin(see first update section). Other possible benefits of this stack are shown in the first part of this series under:
"INSULIN AND ANABOLIC STEROIDS". Of course any potential similarities with AS would be drastically minimized with andro. It should be noted that the term "natural" is used quite loosely.
INSULIN AND CAPTOPRIL
Captopril is an angiotensin converting enzyme(ACE)inhibitor. Its' medical function is to reduce blood pressure. The reason it is included here is because it can have great effects with insulin and AS. I wouldn't reccomend captopril to anyone unless you are hypertensive or are using AS, because it can drop blood pressure to a sub-normal level. A reason captopril is so great is because it increases endogenous growth hormone levels, which you know can be amazing, assuming you've read last month's article. Another benefit to captopril is its' decrease in protein urea(protein loss in urine). No other drug I'm aware of, including AS, GH, or insulin, does this. This means that there will be more protein for those other anabolic drugs to assimilate! Another great use of captopril is the fat loss effect it has. For me it removes the necessity of HCA while using insulin (with AS). Although I still use one 250mgs of HCA/day just for good measure, I could probably get away witho!ut it despite the extreme carb intake after a workout. On a more esoteric note, long term captopril use actually prevents the formation of new Alpha2 adregenic receptors, which would further potentiate fat loss. Also, water retention is minimized through captopril use, which ties into the blood pressure effects. A potential risk while using captopril with insulin is that both drugs do a good job of making one tired/sleepy. Add in a late night, high intensity workout and you'rer ready for bedtime. One can NOT fall asleep while using insulin or you would experience all of the dangerous side effects associated with its' use. A final warning about captopril is that it increases the retention of potassium which makes hyperkalemia (too much potassium)a possibility. Unexcessive intake of this electrolyte should allow for avoidance of any problems in most people. This stack really doesn't have any problems associated with it, as long as common sense is used. It is merely a matter !of responsibility to point out every potential problem, sim!ply so it can be avoided. It should be noted that beta agonists and even working out increase proteinurea.


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Old 09-01-03, 05:49 PM
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nice, but long read
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Old 09-01-03, 05:54 PM
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Long enough to be safe...If it's worth the effort, then it's worth reading my friend....Insulin can be VERY dangerous...There are no quick answers or quick gains...all come with a price tag....

SACRIFICE

Enjoy when you have time.... :O)

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Old 09-01-03, 07:43 PM
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Insulin really hasnt shown to be "anabolic" when not adminstered IV, but, it is ant-catabolic, which, can be just as good..kind of heresay, but nonetheless
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Old 09-01-03, 07:45 PM
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And as for the extra meal, the time in between you are also blunting lypolysis that you would normally have going on, humulin will block lipids from being released and used for energy for 2-4 more hours than humalog. Couple that with some guys using it twice a day, its a wonder people have no idea how they are gaining fat on insulin.
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Old 09-01-03, 08:00 PM
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Quote:
Originally posted by prolangtum
And as for the extra meal, the time in between you are also blunting lypolysis that you would normally have going on, humulin will block lipids from being released and used for energy for 2-4 more hours than humalog. Couple that with some guys using it twice a day, its a wonder people have no idea how they are gaining fat on insulin.
i actually didnt know that. good info. so you are saying humalog is the better choice?
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Old 09-01-03, 10:26 PM
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In my opinion yes....
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Old 09-02-03, 09:59 AM
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Location: At the Vet, picking up my prescription....
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And that opinion is usually a very good one!!!


IMO, I would also use Humalog..... Especially for your first time!!More predictable, out of your system faster, and that equals up to more safty for you!
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