Testosterone replacement therapy in hypogonadal men: assessing benefits, risks, and b - SuperiorMuscle.com

bigscott · #1 01-31-09, 06:24 AM

Hypogonadism is a common condition, especially among older men, but often goes undiagnosed and untreated. It can be associated with a number of signs and symptoms that affect health and quality of life, including feelings of low energy and fatigue; decreased sex drive and performance; decreased muscle mass and strength; decreased bone mineral density; and increased body fat, particularly abdominal fat, a putative risk factor for metabolic syndrome and type 2 diabetes mellitus. The evidence supporting testosterone replacement therapy (TRT) in improving these and related conditions is strong and consistent for body composition and sexual function; moderately consistent for bone mineral density; inconsistent for insulin sensitivity, glycemic control, and lipid profiles; and weak and inconsistent for mood and cognitive function. The concern of some physicians about the potential for TRT to stimulate prostate cancer is not supported by decades of data accumulated to date, though studies of longer duration (eg, 10 years or more) would be even more convincing. Other research needs are discussed. As the front line of health care delivery, primary care physicians need to be vigilant in diagnosing and treating symptomatic hypogonadism. Based on current guidelines, we recommend assessing testosterone levels when an adult man exhibits signs of hypogonadism, and as part of normal medical screening in men starting at age 40 to 50 years, to establish a baseline. A physician should discuss the possibility of TRT with symptomatic patients who have a serum total testosterone level < 300 ng/dL. If TRT is initiated, a patient's response and adverse events should be assessed every 3 to 6 months, and therapy adjusted accordingly.

bigscott · #2 01-31-09, 06:25 AM

[ The concern of some physicians about the potential for TRT to stimulate prostate cancer is not supported by decades of data accumulated to date, though studies of longer duration (eg, 10 years or more) would be even more convincing. ]

i found this tidbit interesting in this article

NYCmitch25 · #3 02-01-09, 06:21 AM

ha that is interesting. i feel strongly that most if not all males over the age of 35 should be on TRT.

3v1lj03 · #4 02-01-09, 10:24 AM

My Doc told me that they think the real cause of prostate cancer in men with low test is high estrogen

**liftsiron** · #5 02-01-09, 04:52 PM

Quote:

Originally Posted by NYCmitch25

ha that is interesting. i feel strongly that most if not all males over the age of 35 should be on TRT.

Nearly all current research points in that direction, as well as E2 estrogen being the culprit in prostate cancer. TRT can protect the heart as well as cognitive and other mental functions and really help to prevent or treat depression.