SARMS S-4

[the art of war]

tell you this much - just dosed 25 this morning, bout to go lift - tastes like gasoline, and damn does that taste linger! Haha, oh well, small price to pay.

[COLOSSUS]

so what does that mean exactly? hahaah i have my S-4 but im waiting for my cycle to end...this is my last week...to run it. whats the lowest dose i can run it so i can get the best for my buck. i wanna be able to run it for as long as possible.

[Bouncer]

yea i would start out with a low dose fro awhile and then slowly raise it.

[the art of war]

Have you guys heard anything about the dosing issues ?

"Analysis of variance showed no significant difference in the CL of S-4 at doses of 0.5, 1 and 10 mg kg−1 ( p>0.05). Previous in vivo studies in the present authors' laboratory showed that the dose required to restore the levator ani muscle weight in castrated animals, an indicator of anabolic activity, compared with that of intact animals was less than 4 mg kg−1 day−1 (Yin et al. 2003). Thus, S-4 demonstrates linear pharmacokinetics within the dose range needed to exert maximal pharmacological effects.

The lack of parent drug in the urine suggests that S-4 is extensively metabolized. Assuming a hepatic blood flow of 13.8 ml min −1 in the rat (Davies and Morris 1993), the hepatic extraction ratio of S-4 would be less than 0.05. Based on this hepatic extraction ratio, a greater than 95% bioavailability (i.e. less than 5% of the drug would be removed by first-pass metabolism) is predicted. The present results confirmed this prediction, as S-4 was completely bioavailable following pharmacologically relevant doses (i.e. doses ≤ 10 mg kg−1).

The CL of S-4 at a dose of 0.5 mg kg−1 (1.92 ml min−1 kg−1) was significantly ( p<0.001) greater than that observed for the 30 mg kg−1 dose (1.00 ml min−1 kg−1). These data suggest that saturation of the drug-metabolizing enzymes might be occurring at this higher dose. Therefore, one would expect to see further suppression of CL following doses greater than 30 mg kg−1. However, due to the potency of S-4, the authors do not anticipate the need for such high doses during clinical use. Forthcoming data from the present authors' laboratory will provide needed information about the hepatic metabolism and pharmacokinetics of S-4 in this and other species.

The pharmacological activity and pharmacokinetics of S-4 in rats suggest that this compound has the properties of an ideal SARM as defined by Negro-Vilar (1999). It is rapidly absorbed following p.o. doses (tmax, 48−84 min), and it exerts tissue-specific anabolic effects in vivo, with anabolic effects in muscle and bone but lesser effects in the prostate and seminal vesicles (Kearbey et al. 2003, Yin et al. 2003). These properties coupled with forthcoming reports from the present authors' laboratory about the pharmacological effects of S-4 in other pertinent animal models and its pharmacokinetics and metabolism in dogs and humans, favour the continued development of S-4 as an orally bioavailable non-steroidal SARM.

So at a dose of 4mg/kg/day (using the dose conversion of .162 for rats) you're looking at a dose of appx 65mgs/day - still much less than the 100+mgs/day some here are using

BUT - at a dose of .5mgs/kg/day - you're only looking at a dose of appx 8mgs for a 100kg human!"

Pharmacokinetics of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide in rats, a non-steroidal selective androgen receptor modulator

I'm going to run @ 50mg / day , split 25 / 25 during the course of the day - there is more info I can post - it came up because somebody was suggesting that the doses people are running are causing the vision issues and what not.

[The_Jackal]

Sorry guys i was away for work.. but yeah I will keep a log going on here and keep you updated, Gotta take some pics and post them up for a before pic. Actually just started s4 today :) 1st thing i have ever really taken... see what happens.

[ROCKETW19]

Can you add more info to this statement? I'm about 2 weeks away from beginning my Clo / nolva PCT after a 15 week cycle.

Are you saying S4 can take the place of Clo / Nolva? Or is it to be used in addition to PCT protocol?

Thanks.

Yes I am sorry if that was not clear it is to be added to PCT. it wont take place of your PCT.
This is only info I have read. I dont know the people giving it or do I know anyone that has tried it.

[Bouncer]

Can you add more info to this statement? I'm about 2 weeks away from beginning my Clo / nolva PCT after a 15 week cycle.

Are you saying S4 can take the place of Clo / Nolva? Or is it to be used in addition to PCT protocol?

Thanks.

no it does not take the place of pct. its just supposedly good to add to pct because of its benefits..

[DNuggets]

No PCT. this is suposed to be used in PCT for best results

Can you add more info to this statement? I'm about 2 weeks away from beginning my Clo / nolva PCT after a 15 week cycle.

Are you saying S4 can take the place of Clo / Nolva? Or is it to be used in addition to PCT protocol?

Thanks.

[bigpapabuff]

I have seen people using sarms for all sorts of reasons, some during cycle, during pct, by itself or as a bridge. Sarms s4 seems to be versatile and if you dose properly I think it can be used for any reason.

[ROCKETW19]

Just waiting for pay day... also thinking of cutting my cycle short so that i can really see what this stuff is about. gonna start on the low end 50 mg/ day, i remember when i took clomid and my eyes were trippin out. it interested me more than freaked me out hahaha

lets talk about the specifics...

should i stop my cycle and use it while clean? i wanna see results from just the SARMs and if its worth switching to this stuff on the long run, but as of now, cost wise like iv mentioned before its cheaper for me just to run a cycle.

I will start with the low end dose. 50mg/day. Agreed?

i will post my weight and estimated BF% when i start.

In comparison to other AAS what substance should i be expecting this to react like? id like to know what im getting myself into lol.

any other info you guys would like to know or would be interested in when i start my log just let me know so i can be ready :weights:

It is suposed to work good in PCT and while on a low dose test. I never heard of anyone running it on its onw yet. I would add it to cycle since you are on right now.

[Bouncer]

Just waiting for pay day... also thinking of cutting my cycle short so that i can really see what this stuff is about. gonna start on the low end 50 mg/ day, i remember when i took clomid and my eyes were trippin out. it interested me more than freaked me out hahaha

lets talk about the specifics...

should i stop my cycle and use it while clean? i wanna see results from just the SARMs and if its worth switching to this stuff on the long run, but as of now, cost wise like iv mentioned before its cheaper for me just to run a cycle.

I will start with the low end dose. 50mg/day. Agreed?

i will post my weight and estimated BF% when i start.

In comparison to other AAS what substance should i be expecting this to react like? id like to know what im getting myself into lol.

any other info you guys would like to know or would be interested in when i start my log just let me know so i can be ready :weights:

kind of hard to get an accurate look at how good this stuff is when you are coming off a cycle. i mean if your weight stay the same people will say "ehh, the sarms doesn't do anything. haha. but the fact that you are coming off AAS and not losing weight will be pretty good. know what i mean. i would like to see you either run it while staying on or completly come off and then run the sarm from base natural level.

[COLOSSUS]

Just waiting for pay day... also thinking of cutting my cycle short so that i can really see what this stuff is about. gonna start on the low end 50 mg/ day, i remember when i took clomid and my eyes were trippin out. it interested me more than freaked me out hahaha

lets talk about the specifics...

should i stop my cycle and use it while clean? i wanna see results from just the SARMs and if its worth switching to this stuff on the long run, but as of now, cost wise like iv mentioned before its cheaper for me just to run a cycle.

I will start with the low end dose. 50mg/day. Agreed?

i will post my weight and estimated BF% when i start.

In comparison to other AAS what substance should i be expecting this to react like? id like to know what im getting myself into lol.

any other info you guys would like to know or would be interested in when i start my log just let me know so i can be ready :weights:

[ROCKETW19]

Yes Jackel keep a log here. If someone on this board gives us info I would trust it more there can be no hidden ageandas trying to pump up a source just for fucking money.
Other boards I just cant tell who is who so i take it all with a grain of salt.

I am realy intrested in the eye side effects. Is it dose dependant or what?

[tballz]

I've seen other logs on other boards. SARMs looks real promising.

Another log would be great...keep us posted, Jackal.

[ROCKETW19]

Well im just getting back in to the workout stage and i have a bottle of s4, I could be the guinea pig :) or you want a regular from the board?

Ya start a thread and update when ever you can. So we can all see the progress