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The Study - BPC-157 Enhances The GH Receptor
BPC-157 is a synthetic analog of a substance made in your pancreas and has been utilized for a few years now in wound healing. It has been added to gel packs that are used by EMT for burn victims and it is a new additive to stomach ulcer medication as it is able to heal an ulcer in 5 days.
There is a lot of new testing and experimentation going on with this protein both in the scientific community and the personal community. There are several completed and on going research around tendon healing. The severed tendon of a rat can grow back together, in short order, utilizing BPC-157. In one of those studies, the nerves for the foot of the rat were accidentally cut along with the tendon and the rat, not being able to feel his foot, chewed 1/2 of it off. As the results required were with regards to the tendon, not the foot the rat was kept in the study and at the end of the study it was found that the rat had regrown the missing part of its foot.
BPC-157 has been studied and put in field testing by the Chinese Army to allow quick healing from injuries. Of course, this is meant to get the solders back out on the field as soon as possible but despite its indented use in the study, the potential other uses are mind boggling.
BPC-157 has been tested on and found to reduce and/or completely eliminate the swelling caused in the intestines from Crones disease. Not just Crones either, it can have this effect from any IBS.
If you think about where BPC-157 is produced in the body and know what it does, it makes sense that this is a “healing” substance naturally produced by our body and pumped into the digestive tract. Why there? Well, it is very stable in the digestive tract and therefore is able to enter the blood stream and go through out the body to aid in healing anywhere. Technically, this should aid in the healing of all internal organs, even the brain and nerves. In fact, it has already been trailed on liver damage and found to be able to reverse excessive alcohol damage.
It is being used on the black market, in injectable form, by body builders because it can heal muscle very fast. After breaking down muscle in weight lifting, the BPC-157 can heal the muscles quickly allow those same muscles to be broken down for building again faster.
Bottom Line
What this means to bodybuilders is that BPC-157 potentiates HGH, so taking BPC-157 prior to HGH will potentially make it more effective by enhancing the HGH receptor.
Abstract:
BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies. However, the underlying mechanism has not been fully clarified. The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat. From the result of cDNA microarray analysis, growth hormone receptor was revealed as one of the most abundantly up-regulated genes in tendon fibroblasts by BPC 157. BPC 157 dose- and time-dependently increased the expression of growth hormone receptor in tendon fibroblasts at both the mRNA and protein levels as measured by RT/real-time PCR and Western blot, respectively. The addition of growth hormone to BPC 157-treated tendon fibroblasts dose- and time-dependently increased the cell proliferation as determined by MTT assay and PCNA expression by RT/real-time PCR. Janus kinase 2, the downstream signal pathway of growth hormone receptor, was activated time-dependently by stimulating the BPC 157-treated tendon fibroblasts with growth hormone. In conclusion, the BPC 157-induced increase of growth hormone receptor in tendon fibroblasts may potentiate the proliferation-promoting effect of growth hormone and contribute to the healing of tendon.
BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies. However, the underlying mechanism has not been fully clarified. The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat. From the result of cDNA microarray analysis, growth hormone receptor was revealed as one of the most abundantly up-regulated genes in tendon fibroblasts by BPC 157. BPC 157 dose- and time-dependently increased the expression of growth hormone receptor in tendon fibroblasts at both the mRNA and protein levels as measured by RT/real-time PCR and Western blot, respectively. The addition of growth hormone to BPC 157-treated tendon fibroblasts dose- and time-dependently increased the cell proliferation as determined by MTT assay and PCNA expression by RT/real-time PCR. Janus kinase 2, the downstream signal pathway of growth hormone receptor, was activated time-dependently by stimulating the BPC 157-treated tendon fibroblasts with growth hormone. In conclusion, the BPC 157-induced increase of growth hormone receptor in tendon fibroblasts may potentiate the proliferation-promoting effect of growth hormone and contribute to the healing of tendon.
There is a lot of new testing and experimentation going on with this protein both in the scientific community and the personal community. There are several completed and on going research around tendon healing. The severed tendon of a rat can grow back together, in short order, utilizing BPC-157. In one of those studies, the nerves for the foot of the rat were accidentally cut along with the tendon and the rat, not being able to feel his foot, chewed 1/2 of it off. As the results required were with regards to the tendon, not the foot the rat was kept in the study and at the end of the study it was found that the rat had regrown the missing part of its foot.
BPC-157 has been studied and put in field testing by the Chinese Army to allow quick healing from injuries. Of course, this is meant to get the solders back out on the field as soon as possible but despite its indented use in the study, the potential other uses are mind boggling.
BPC-157 has been tested on and found to reduce and/or completely eliminate the swelling caused in the intestines from Crones disease. Not just Crones either, it can have this effect from any IBS.
If you think about where BPC-157 is produced in the body and know what it does, it makes sense that this is a “healing” substance naturally produced by our body and pumped into the digestive tract. Why there? Well, it is very stable in the digestive tract and therefore is able to enter the blood stream and go through out the body to aid in healing anywhere. Technically, this should aid in the healing of all internal organs, even the brain and nerves. In fact, it has already been trailed on liver damage and found to be able to reverse excessive alcohol damage.
It is being used on the black market, in injectable form, by body builders because it can heal muscle very fast. After breaking down muscle in weight lifting, the BPC-157 can heal the muscles quickly allow those same muscles to be broken down for building again faster.
Bottom Line
What this means to bodybuilders is that BPC-157 potentiates HGH, so taking BPC-157 prior to HGH will potentially make it more effective by enhancing the HGH receptor.