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Been taking this stuff for the last few days and I can say that I feel pretty good.. not 100 percent, but @ least i don't have suicidal thoughts or feel manic (knocking on wood..
My gabas are so down regulate from the meds hence why I feel the way I felt.. I also have high levels of glutamate which is not good.. L theanine passes the blood brain barrier and unregulates your Gaba.. placebo or not i think this shit works..
THEANINE could be a highly useful ANXIOLYTIC, since it DOES NOT function as a GABA RECEPTOR AGONIST but UPREGULATES THE PRODUCTION OF GABA within the brain, functions as a GLUTAMATE RECEPTOR ANTAGONIST, and enhances ALPHA-WAVE production within the brain.
See the following studies:
J Clin Psychiatry. 2011 Jan;72(1):34-42. Epub 2010 Nov 30.
L-theanine relieves*positive, activation, and*anxiety symptoms*in patients with schizophrenia and schizoaffective disorder:*an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
Ritsner MS, Miodownik C, Ratner Y, Shleifer T, Mar M, Pintov L, Lerner V.
Source
Department of Psychiatry, The Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
Abstract
OBJECTIVE:*
L-theanine is a unique amino acid present almost exclusively in the tea plant. It possesses neuroprotective, mood-enhancing, and relaxation properties. This is a first study designed to evaluate the efficacy and tolerability of L-theanine augmentation of antipsychotic treatment of patients with chronic schizophrenia and schizoaffective disorder.
METHOD:*
60 patients with DSM-IV schizophrenia or schizoaffective disorder participated in an 8-week, double-blind, randomized, placebo-controlled study. 400 mg/d of L-theanine was added to ongoing antipsychotic treatment from February 2006 until October 2008. The outcome measures were the Positive and Negative Syndrome Scale (PANSS), the Hamilton Anxiety Rating Scale (HARS), the Cambridge Neuropsychological Test Automated Battery (CANTAB) for neurocognitive functioning, and additional measures of general functioning, side effects, and quality of life.
RESULTS:*
40 patients completed the study protocol. Compared with placebo, L-theanine augmentation was associated with reduction of anxiety (P = .015; measured by the HARS scale) and positive (P = .009) and general psychopathology (P < .001) scores (measured by the PANSS 3-dimensional model). According to the 5-dimension model of psychopathology, L-theanine produced significant reductions on PANSS positive (P = .004) and activation factor (P = .006) scores compared to placebo. The effect sizes (Cohen d) for these differences ranged from modest to moderate (0.09-0.39). PANSS negative and CANTAB task scores, general functioning, side effect, and quality of life measures were not affected by L-theanine augmentation.*L-theanine was found to be a safe and well-tolerated medication.
CONCLUSIONS:*
L-theanine augmentation*of antipsychotic therapy*can ameliorate*positive, activation, and*anxiety symptomsin schizophrenia and schizoaffective disorder patients.*Further long-term studies of L-theanine are needed to substantiate the clinically significant benefits of L-theanine augmentation.
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My gabas are so down regulate from the meds hence why I feel the way I felt.. I also have high levels of glutamate which is not good.. L theanine passes the blood brain barrier and unregulates your Gaba.. placebo or not i think this shit works..
THEANINE could be a highly useful ANXIOLYTIC, since it DOES NOT function as a GABA RECEPTOR AGONIST but UPREGULATES THE PRODUCTION OF GABA within the brain, functions as a GLUTAMATE RECEPTOR ANTAGONIST, and enhances ALPHA-WAVE production within the brain.
See the following studies:
J Clin Psychiatry. 2011 Jan;72(1):34-42. Epub 2010 Nov 30.
L-theanine relieves*positive, activation, and*anxiety symptoms*in patients with schizophrenia and schizoaffective disorder:*an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
Ritsner MS, Miodownik C, Ratner Y, Shleifer T, Mar M, Pintov L, Lerner V.
Source
Department of Psychiatry, The Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
Abstract
OBJECTIVE:*
L-theanine is a unique amino acid present almost exclusively in the tea plant. It possesses neuroprotective, mood-enhancing, and relaxation properties. This is a first study designed to evaluate the efficacy and tolerability of L-theanine augmentation of antipsychotic treatment of patients with chronic schizophrenia and schizoaffective disorder.
METHOD:*
60 patients with DSM-IV schizophrenia or schizoaffective disorder participated in an 8-week, double-blind, randomized, placebo-controlled study. 400 mg/d of L-theanine was added to ongoing antipsychotic treatment from February 2006 until October 2008. The outcome measures were the Positive and Negative Syndrome Scale (PANSS), the Hamilton Anxiety Rating Scale (HARS), the Cambridge Neuropsychological Test Automated Battery (CANTAB) for neurocognitive functioning, and additional measures of general functioning, side effects, and quality of life.
RESULTS:*
40 patients completed the study protocol. Compared with placebo, L-theanine augmentation was associated with reduction of anxiety (P = .015; measured by the HARS scale) and positive (P = .009) and general psychopathology (P < .001) scores (measured by the PANSS 3-dimensional model). According to the 5-dimension model of psychopathology, L-theanine produced significant reductions on PANSS positive (P = .004) and activation factor (P = .006) scores compared to placebo. The effect sizes (Cohen d) for these differences ranged from modest to moderate (0.09-0.39). PANSS negative and CANTAB task scores, general functioning, side effect, and quality of life measures were not affected by L-theanine augmentation.*L-theanine was found to be a safe and well-tolerated medication.
CONCLUSIONS:*
L-theanine augmentation*of antipsychotic therapy*can ameliorate*positive, activation, and*anxiety symptomsin schizophrenia and schizoaffective disorder patients.*Further long-term studies of L-theanine are needed to substantiate the clinically significant benefits of L-theanine augmentation.
Sent from my SM-G950F using Tapatalk