Tweet
Dear ladies and gents,
Gonna be sharing my thoughts on IGF-1 LR3/DES.
Many websites selling IGF-1 LR3/DES peptides are referring to SIGMA Aldrich/Repligen websites :
"LONGŪ R3 IGF-I is a recombinant analog of human insulin-like growth factor-I (IGF-I) that has been specifically engineered for the enhancement of cell culture performance. It is more biologically potent in vitro than either insulin or native IGF-I and has been shown to significantly increase recombinant protein production. It is ideal for both research and large-scale culture systems utilizing serum-free or low-level serum applications"
Repligen :
"LONGŪR3 IGF-I is a critically important mitogenic growth factor often used in mammalian cell culture to increase yield significantly."
"More biologically potent in vitro than either insulin or native IGF-I"
In vitro! This is what SOME igf-1 Lr3/Des PEPTIDE vendors forget to mention... IGF-1 LR3 is superior to IGF-1 when it comes to IN VITRO RESEARCH, we can simply call it a better reagent for certain laboratory applications. It may be performing better in a "tube" does it work the same IN VIVO???
Have you seen a single study done on HUMANS with IGF-1 LR3/DES? Try googling it and feel free to post a link to the study here.
Sold to athletes as a more potent version of Recombinant Human IGF-1 = The Perfect Snake oil.
Why? It won't raise your IGF-1 levels, it can't be detected in your blood sample. Not a single blood test done by anyone using IGF-1 LR3 proven the opposite. The molecule is different, the lab equipment used to detect IGF-1 won't detect IGF-1 LR3/DES. So the peptide you get can be anything.
If IGF-1 LR3/DES works, what's the mechanism of action in human body?
Recombinant Human IGF-1 binds to IGF-1 and Insulin receptors. If the molecule is different from the RH IGF-1, will IGF-1 LR3/DES bind to the same receptors? FYI : IGF-1 LR3 = 83 Amino acids, IGF-1 = 70 AA. Can 2 different keys gain access the same lock?
Antibodies? Let's not forget that IGF-1 LR3 peptide doesn't resemble any protein/molecule produced by our body. We all remember the rumor that some "Chinese" factories were selling 192 AA instead of 191 AA (HGH) which the community believe led to the red welts. It's a common sense, you don't want to inject something that our body can reject. IGF-1 LR3 (83 AA) is that 192 AA, if you don't get the red welts, it doesn't mean your body doesn't waste it's resources on producing antibodies and fighting the "Intruder Growth Factor LR3". Weakened immune system is one of the consequences of these experiments. Yet not a single research can confirm the statement is wrong.
To sum it up :
Gonna be sharing my thoughts on IGF-1 LR3/DES.
Many websites selling IGF-1 LR3/DES peptides are referring to SIGMA Aldrich/Repligen websites :
"LONGŪ R3 IGF-I is a recombinant analog of human insulin-like growth factor-I (IGF-I) that has been specifically engineered for the enhancement of cell culture performance. It is more biologically potent in vitro than either insulin or native IGF-I and has been shown to significantly increase recombinant protein production. It is ideal for both research and large-scale culture systems utilizing serum-free or low-level serum applications"
Repligen :
"LONGŪR3 IGF-I is a critically important mitogenic growth factor often used in mammalian cell culture to increase yield significantly."
"More biologically potent in vitro than either insulin or native IGF-I"
In vitro! This is what SOME igf-1 Lr3/Des PEPTIDE vendors forget to mention... IGF-1 LR3 is superior to IGF-1 when it comes to IN VITRO RESEARCH, we can simply call it a better reagent for certain laboratory applications. It may be performing better in a "tube" does it work the same IN VIVO???
Have you seen a single study done on HUMANS with IGF-1 LR3/DES? Try googling it and feel free to post a link to the study here.
Sold to athletes as a more potent version of Recombinant Human IGF-1 = The Perfect Snake oil.
Why? It won't raise your IGF-1 levels, it can't be detected in your blood sample. Not a single blood test done by anyone using IGF-1 LR3 proven the opposite. The molecule is different, the lab equipment used to detect IGF-1 won't detect IGF-1 LR3/DES. So the peptide you get can be anything.
If IGF-1 LR3/DES works, what's the mechanism of action in human body?
Recombinant Human IGF-1 binds to IGF-1 and Insulin receptors. If the molecule is different from the RH IGF-1, will IGF-1 LR3/DES bind to the same receptors? FYI : IGF-1 LR3 = 83 Amino acids, IGF-1 = 70 AA. Can 2 different keys gain access the same lock?
Antibodies? Let's not forget that IGF-1 LR3 peptide doesn't resemble any protein/molecule produced by our body. We all remember the rumor that some "Chinese" factories were selling 192 AA instead of 191 AA (HGH) which the community believe led to the red welts. It's a common sense, you don't want to inject something that our body can reject. IGF-1 LR3 (83 AA) is that 192 AA, if you don't get the red welts, it doesn't mean your body doesn't waste it's resources on producing antibodies and fighting the "Intruder Growth Factor LR3". Weakened immune system is one of the consequences of these experiments. Yet not a single research can confirm the statement is wrong.
To sum it up :
- The mechanism of action of IGF-1 LR3/DES peptides in human body : UNKNOWN.
- Detectable in blood? No.
- Effectiveness: Yet to be proven.
- Safety: Yet to be studied.
- Antibodies?: Yet to be studied.
- Created for In vitro research and marketed as such by Repligen/Sigma Aldrich.
No Human/Pharma Grade version of the substance exists.
Comment