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Old 11-05-17, 04:36 AM
In pursuit of healthy aging
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Manipulating mitochondrial networks inside cells — either by dietary restriction or by genetic manipulation that mimics it — may increase lifespan and promote health, according to new research from Harvard T.H. Chan School of Public Health.

The*study, published Oct. 26 online in*Cell Metabolism,*sheds light on the basic biology involved in cells’ declining ability to process energy over time, which leads to aging and age-related disease, and how interventions such as periods of fasting might promote healthy aging.

Mitochondria — the energy-producing structures in cells — exist in networks that dynamically change shape according to energy demand. Their capacity to do so declines with age, but the impact this has on metabolism and cellular function was previously unclear. In this study, the researchers showed a causal link between dynamic changes in the shapes of mitochondrial networks and longevity.

The scientists used*C. elegans*(nematode worms), which live just two weeks and thus enable the study of aging in real time in the lab. Mitochondrial networks inside cells typically toggle between fused and fragmented states. The researchers found that restricting the worms’ diet, or mimicking dietary restriction through genetic manipulation of an energy-sensing protein called AMP-activated protein kinase (AMPK), maintained the mitochondrial networks in a fused or “youthful” state. In addition, they found that these youthful networks increased lifespan by communicating with organelles called peroxisomes to modulate fat metabolism.



“Low-energy conditions such as dietary restriction and intermittent fasting have previously been shown to promote healthy aging. Understanding why this is the case is a crucial step toward being able to harness the benefits therapeutically,” said Heather Weir, lead author of the study, who conducted the research while at Harvard Chan School and is now a research associate at Astex Pharmaceuticals. “Our findings open up new avenues in the search for therapeutic strategies that will*reduce our likelihood of developing age-related diseases as we get older.”

“Although previous work has shown how intermittent fasting can slow aging, we are only beginning to understand the underlying biology,” said*William Mair, associate professor of genetics and complex diseases at Harvard Chan School and senior author of the study. “Our work shows how crucial the plasticity of mitochondria networks is for the benefits of fasting. If we lock mitochondria in one state, we completely block the effects of fasting or dietary restriction on longevity.”

Next steps for the researchers including testing the role mitochondrial networks have in the effect of fasting in mammals, and whether defects in mitochondrial flexibility might explain the association between obesity and increased risk for age-related diseases.



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Old 11-05-17, 10:15 AM
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I wonder if GH has any effect on "mitochondrial networks"?
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Old 01-30-18, 01:28 PM
In pursuit of healthy aging
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Analysts at Mayo Clinic in Minnesota have possessed the capacity to hereditary dispose of these broken, maturing cells in mice. (Shutter stock/File)

Specialists on the front line of against maturing prescription say the field is blasting, with treatments not too far off to target sicknesses like malignancy and Alzheimer's and make for a more advantageous, more established populace in the years to come.

Such cures are progressively critical on account of the world's maturing populace. Developing old, specialists say, is a main hazard factor for most human sicknesses and a noteworthy financial issue.

"Over the most recent 20 years this field of research on maturing has detonated," said Felipe Sierra, executive of the division of maturing science at the US National Institute of Aging.

"We are drawing near to having medications to keep the sicknesses identified with maturing," he included.

A significant part of the examination done as such far has been on lab creatures and straightforward life forms like worms, which empower specialists to both measure and change future.

For example, specialists were astonished to discover that by controlling only 17 qualities, which likewise exist in people, they could twofold the future of a much-contemplated worm called C. elegant, and even influence mice to live 60 percent longer.

Analysts have additionally discovered that a noteworthy diminished in calorie admission can have a similar impact on these qualities.

"We realize that the amassing of cell harm is the reason for some maladies," said Luigi Fontana, educator of dietary science at Washington University School of Medicine, St. Louis and University of Brescia in Italy.

"Be that as it may, when you go long stretches without nourishment, the subsequent metabolic changes seem to fortify autograph or a characteristic wiping out of your body's harmed cells."

Confining calories for long stretches regularly demonstrates "excessively troublesome" for individuals, said Sierra.

"There are medicates now that can impersonate the impacts of caloric decrease," he included.
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Old 01-30-18, 01:31 PM
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Quote:
Originally Posted by Karen A. Callen View Post
Analysts at Mayo Clinic in Minnesota have possessed the capacity to hereditary dispose of these broken, maturing cells in mice. (Shutter stock/File)

Specialists on the front line of against maturing prescription say the field is blasting, with treatments not too far off to target sicknesses like malignancy and Alzheimer's and make for a more advantageous, more established populace in the years to come.

Such cures are progressively critical on account of the world's maturing populace. Developing old, specialists say, is a main hazard factor for most human sicknesses and a noteworthy financial issue.

"Over the most recent 20 years this field of research on maturing has detonated," said Felipe Sierra, executive of the division of maturing science at the US National Institute of Aging.

"We are drawing near to having medications to keep the sicknesses identified with maturing," he included.

A significant part of the examination done as such far has been on lab creatures and straightforward life forms like worms, which empower specialists to both measure and change future.

For example, specialists were astonished to discover that by controlling only 17 qualities, which likewise exist in people, they could twofold the future of a much-contemplated worm called C. elegant, and even influence mice to live 60 percent longer.

Analysts have additionally discovered that a noteworthy diminished in calorie admission can have a similar impact on these qualities.

"We realize that the amassing of cell harm is the reason for some maladies," said Luigi Fontana, educator of dietary science at Washington University School of Medicine, St. Louis and University of Brescia in Italy.

"Be that as it may, when you go long stretches without nourishment, the subsequent metabolic changes seem to fortify autograph or a characteristic wiping out of your body's harmed cells."

Confining calories for long stretches regularly demonstrates "excessively troublesome" for individuals, said Sierra.

"There are medicates now that can impersonate the impacts of caloric decrease," he included.
Stfu Karen before i kick u in the nuts

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