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Old 01-09-17, 08:12 PM
jolter604's Avatar
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Join Date: Jul 2016

Sulbutiamine*(brand name:*Arcalion) is a synthetic derivative of*thiamine*(vitamin B1). As a*dimer*of two modified thiamine molecules, it is a lipophilic compound that crosses theblood–brain barrier*more readily than thiamine and increases the levels of thiamine and thiamine phosphate esters in the brain.[1]Sulbutiamine was discovered in Japan in an effort to develop more useful thiamine derivatives since it was hoped that increasing the*lipophilicity*of thiamine would result in better*pharmacokinetic*properties.[2]

Although its clinical efficacy is uncertain,[3]*it is the only compound used to treat*astheniathat is known to selectively target the areas that are involved in the condition.[4]*In addition to its use as a treatment for chronic fatigue, sulbutiamine may improve*memory, reduce psycho-behavioural inhibition, and improve*erectile dysfunction. At therapeutic dosages, it has few reported adverse effects. It is available for*over-the-counter sale*as a nutritional supplement.
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