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Old 01-08-17, 10:44 AM
Evening versus morning injections of growth hormone (GH)
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https://www.ncbi.nlm.nih.gov/pubmed/2294131

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We conclude that the metabolic effects of sc GH injections are clearly influenced by the time of administration and that the closest similarity to normal hormone and metabolite patterns and relationships is reached by GH injection in the evening in GH-deficient patients.


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Abstract
Since serum GH in normal subjects displays a circadian variation with a major and consistent surge after the onset of sleep we examined whether the time of GH administration in GH-deficient patients had any impact on its action. Eight GH-deficient patients all underwent 3 4-week study schedules in random order: 1) evening (2000 h) sc GH injections, 2) morning (0800 h) sc GH injections, and 3) no GH administration. At the end of each period the patients were admitted to hospital for 24-h measurements of hormones and metabolites. For comparison, 10 age- and sex-matched healthy untreated subjects were hospitalized once under identical conditions. Mean (+/- SE) GH availability, i.e. the area under the curve (AUC; micrograms per L/12 h) for 12 h after injection was significantly greater after evening injection than after morning injections [83.3 +/- 25.4 (evening) vs. 46.0 +/- 10.6 (morning); P less than 0.01]. This might be due to higher skin and sc temperatures when in bed. The 2000-0800 h AUC after evening injection was similar to the corresponding AUC in the reference group. Mean 24-h serum insulin-like growth factor-I levels (micrograms per L) were similar after evening (189.8 +/- 2) and morning (179.5 +/- 5.3) injections (P = 0.8), but the latter displayed a circadian variation suggesting that a steady state had not been reached. Both were significantly lower than the stable reference value (248.4 +/- 3.6 micrograms/L). Blood glucose profiles after morning and evening GH did not differ from that of the reference group, whereas blood glucose decreased when the patients received no GH (P less than 0.01). Daytime (0800-2400 h) insulin levels were increased after morning injections (P less than 0.05). Nighttime levels of lipid intermediates were below normal in the untreated state and after morning injection (P less than 0.05), whereas nighttime blood alanine tended to be above normal after morning GH injection (P = 0.08). Highly significant inverse relationships between circadian lipid intermediates and both blood alanine and lactate concentrations were observed in the reference group and in the patients after evening injections. These relationships disappeared after morning injections. We conclude that the metabolic effects of sc GH injections are clearly influenced by the time of administration and that the closest similarity to normal hormone and metabolite patterns and relationships is reached by GH injection in the evening in GH-deficient patients.
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Old 01-10-17, 09:15 AM
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So you doing evenings?
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Old 01-10-17, 10:36 AM
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After doing some more reading I split my injections up into morning and evening. 2iu morning and 2iu evening. But since you're only running 2iu, one injection should be fine.
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Old 01-10-17, 11:08 AM
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After doing some more reading I split my injections up into morning and evening. 2iu morning and 2iu evening. But since you're only running 2iu, one injection should be fine.
when evenings before bed?
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Old 01-10-17, 11:16 AM
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AM and PWO were best IMO.
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Old 01-10-17, 11:37 AM
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Why do you like PWO?

What doses do you run?

Do you ever feel your insulin levels impacted by your GH use?
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Old 01-10-17, 03:30 PM
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ran 5-6iu's for 6 months ED
roid like results,
started feeling a little weird towards the end, listened to my body took a break,
not really insulin related feelings like a diabetic such as getting light headed and dizzy, needing to eat, etc. i get like that on long test cycles too.
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Old 01-10-17, 07:13 PM
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Originally Posted by Chadd77 View Post
Why do you like PWO?

What doses do you run?

Do you ever feel your insulin levels impacted by your GH use?
I felt pwo is when your catabolic natural GH release
I wo in the afternoon.

You could take Metforman but I never have
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Old 01-11-17, 12:40 AM
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Anything over 4iu will impact I skin effects. Evenings is best but not right before bed.
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Old 01-11-17, 06:03 AM
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Originally Posted by jack tors View Post
So you doing evenings?
For now, mornings.

Once this box of GH is gone and I start to use mine, then I'll switch to evenings.

I want to explore and have labs done while I do morning and then transition to evenings. I will do labs then as well to see if there's any difference at all, for me.

I need to post my log today, interesting 3 days already of taking GH
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Old 01-11-17, 06:17 AM
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Anything over 4iu will impact I skin effects. Evenings is best but not right before bed.
What do you mean will impact skin effects?

What doses have you ran before? What was the sweet spot for you?
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Old 01-13-17, 09:25 PM
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Originally Posted by Mr I View Post
Anything over 4iu will impact I skin effects. Evenings is best but not right before bed.
empty stomach best despite time of day

in this order, IMO
1st thing in AM or if you get up at 5am to piss
next best time early afternoon (catabolic-world HGH has something on this)
The next best time would be PWO (for me is early afternoon)
Evening on empty stomach (after dinner)
Last right before bed (more beneficial if your over 60 yr old)
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Old 01-20-17, 02:27 AM
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Have you tried HGH pills or just injection? Is it giving the same effectiveness?
No such thing as HGH pills. Pure garbage. Must be injected.
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Old 01-20-17, 02:32 AM
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No such thing as HGH pills. Pure garbage. Must be injected.
So, yes, it's similar to HCG, most in form of droplets or pills are useless, and injection still rules.
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Old 04-24-17, 06:08 AM
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I shoot mid afternoon about 2 hours after a meal and about an hour before my next meal. Just a matter of convenance. If you have good GH it doesn't really matter when you shoot in the real world, you will get great results over time regardless.

This is one of those deals that looks good on paper but in real world use it's all the same. I've ran GH in morning, midday, and night. I've split doses and I've shot once per day. The results after 6 months of good GH are always the same. There may be some small difference that could be measured by science but I assure you the difference is so small that you'd never be able to tell the difference in the real world. Just use it to whatever is most convenient to you.

My only rule is to avoid shooting around meal time. I like to shoot between meals because I remember reading how eating around the time of GH injection can reduce the GH spike. This may be bro science but it's what I've always done.
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Old 04-24-17, 09:04 AM
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Originally Posted by Bouncer View Post
No such thing as HGH pills. Pure garbage. Must be injected.
there's some sort of peptide or sarm in pill form which is suppose to mimic GH like results. Its popular at my local supplement. 3-6 months of use to see results, supposedly it works from feedback he gets. IDK.
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Old 04-24-17, 03:15 PM
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there's some sort of peptide or sarm in pill form which is suppose to mimic GH like results. Its popular at my local supplement. 3-6 months of use to see results, supposedly it works from feedback he gets. IDK.
Its probably MK-677
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