My IGF-1 journal.

[hitmansb]

So far, this is not looking very promising. I'm glad I've held off on ordering this stuff, as I've yet to read a testimonial of someone using it that has lived up to the hype. Interested to see if things change at all during week 2.

[Choke03]

"Just curious but what in the hell is a non-responder" - Someone who does not respond to IGF.

"And just who are these people that you've been monitoring that constitutes for the 90% ..What board are all these people from?"
Polls have been taken at beyond mass and muscle chem before that. Easy to check. I read every and all IGF threads on the internet I can find.
Do you think this comment is incorrect ? Look on this thread, a handfull of people on here have used it, only bouncer has not seen any results. He has been on a total of a week, I look forward to seeing if he notices any changes in the upcoming days.

"Whats put your protein level through the roof mean ?"
3 grams + per each pound of LBM.


"Sorry if I sound flippant I'll disappear now and leave you to help with this thread"
No worries at all, I am just here to learn and share.

[hitmansb]

Bouncer...what's the word? Have you seen any results at all?

[Sootybaby]

It hurts!

Hello guys.

I did the IGF Long 3 from grow pep and reconstituded in 1ml of Sterile water with 60ul of acetic acid (100mM) as per instructions ( it could also be reconstituted using 10mM HCL). I then used 33ul added to 66ul of sterlile water for injection sub Q, and yep it hurt and I had the swelling t the point of injection. My worry is that the acetic acid may be acting as an irritant (like a bee sting). Maybe if I buffer with 66ul or more of phosphte buffered saline it may not be so aggressive. Any thoughts? Would seem a waste if I had to ditch this batch as I don't want to I.M. inject 'coz I may be just importing the problem to my muscles. I wish I had just reconstituted in water alone mainly becase I aliquoted it in batches of 100ul and froze them so the stability shouldn't really be an issue!

[Bouncer]

Sorry Guys I was away for the the weekend.

Well its now day 12 and I cant really say its done much. I will be honest here and say that IMO it dosent compare to Jintropin. It may be different for others but it just dosent seem to do much for me.

[Chadd77]

Glad I held off on buying!

[hitmansb]

I was skeptical when the theorists were talking about this stuff adding 15 pounds of muscle in a few weeks back when this stuff first came on the scene....looks like it really was too good to be true.

[Choke03]

I was looking forward to bouncers journal cause he was dedicated to keeping it up everyday. Unfortunatly has not gotten the results that many have. It would be cool if others with experience using IGF would chime in here to put there perspectives both positive and negative.

[GOHAN]

Interesting, many people doesn't believe in anabolic features of IGF-1 if you take it by itself. However, Bouncer, are you sure about your source?

[Sootybaby]

I am also giving the IGF R3 a go. Running about 33ug's three times a week, which should give me a ten week window. That is if I can be bothered with the pain of the site injections. Diluting the reconstituted formulation(1mg in 1ml sterile water with 100mM acetic acid) in about 150ul of PBS still gives localised inflammation!(I was hoping the PBS may neutralise reaction to the acid if that is the cause of the reaction).

I'm sticking to sub-cut in calves 'cos my skin is less sensitive there. Since it is a hormone and therefore acting systemically I can't see an advantage in I.M. injections as well unless they mean less pain. Who else has had the site injection pain and how have they resolved this? The IGF R3 I am using is bona fide, of that I am sure.

[Sootybaby]

I have decided to change tack on the IGF1. Here is my reasoning.

I have doubt's about the use of Long L3 (gro-pep et al). The modification to this analogue of human IGF-1 results in it not reacting to IGF-1 binding proteins (IGF bp) there are number of bp (seven or more) and they play a part in transport and regulation of the effects of IGF-1 in tissues. In serum IGF-1 is predominantly bound to bp-3. In order to cross into tissues from the blod it needs to then bind to bp-2, a cross membrane shuttle. No binding to bp-2 no movement of IGF-1 into tissues.

This is a fundemental flaw in using Long 3. By sub-cutaneous injection it will not get into the bloodstream period and even by intra muscular injection you would need many, many injections into the muscle to get usefull distribution! This lack of binding is not an issue in tissue culture (its actual use) because cultures are usually single cell layers where the IGF-1 receptors are exposed directly to the media containing the long 3.

Use of normal, receptor grade IGF-1 will be effective. However, the amounts produced naturally in the body are relatively high and to boost these levels you would need a prohibitively expensive amount of IGF-1. It has been demostrated that by using Growth Hormone at even 2 I.U. per day can lead to a threefold increase in IGF-1 lvels in elderly patients( who are often GH deficient) and so this is the most effective means of increasing IGF-1 levels.

I think that the pain of injections may be caused by the modification to the IGF-1 analogue. Whilst the bulk of the protien is human (and should not cause any adverse reaction when injected) i suspect that this modification is not a naturally occuring form and as such this is the cause of the pain (on injection), not the fact that the IGF-1 is reconstituted in ( a very mild) acid (proof of this is that mixed with say 4x it's volume of PBS which should neutralize the acid has no effect on the inflammatory response

I believe that the bouncer has given a usefull and true report on the use of IGF-1 long 3 and when you look at the science behind it we should give up on this product and move on!

My supply is staying in the freezer. I may use it tissue culture studies (its correct use) but that's it!

Cheers all,

Sootybaby

[Chadd77]

Bouncer? Any updates for us?

[Bouncer]

Originally posted by Chadd77
Bouncer? Any updates for us?

nope. not getting a thing from it bro. sorry

[goldylight]

sorry to hear that - i love the shit - aside from the muscle transformation - i have almost a full head of hair again.

[Eating Machine]

Well Bouncer that stinks that you did not see results. My changes pretty much stopped after 2 weeks when I posted earlier in the thread. I attribute this to the low dose of approximately 33mcgs per day. Next time I will start at 50mcg and see what happens.