I don't consider myself a professional chemist or any thing but here are a few thoughts of mine.
I'm assuming that the benzoate ester in the 17 poss. of the estragen make that molecule highly hydrophobic. I thought that maybe one could treat a soln. of synovex pellets aq. in MeOH with the anhydride of the propionate ester. This way you would not change the test and the ester of the estrogen would be much smaller. My thought is that with this decrease in hydrophobic suface area purhaps the 3-hydroxyl group would make the estrogen water soluble.
I also was wondering if i just did a saponification and isolated straight test. could I treat with work up of a desired anhydride and get an esterified Test.
Those were just a few thoughts I had.
I'm assuming that the benzoate ester in the 17 poss. of the estragen make that molecule highly hydrophobic. I thought that maybe one could treat a soln. of synovex pellets aq. in MeOH with the anhydride of the propionate ester. This way you would not change the test and the ester of the estrogen would be much smaller. My thought is that with this decrease in hydrophobic suface area purhaps the 3-hydroxyl group would make the estrogen water soluble.
I also was wondering if i just did a saponification and isolated straight test. could I treat with work up of a desired anhydride and get an esterified Test.
Those were just a few thoughts I had.

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