progesterone

[kingj]

What is the best thing to take to block progesterone, im running anadrol in my cycle at 100mgs a day and was wondering what i should do to block this beings as anadrol is strongly progestagenic.

[ROCKETW19]

i think someone gave you bad info bro a-bombs are estrogenic not progest. and of coarse for estro people love nolva i perfer not to use anything untill i feel it in my nipps then i use it.

[spidey]

Actually, he had it right in the first place. Anadrol is a potent progestin. It doesn't aromatize so no estrogen is produced.

There actually aren't that many drugs that are true antiprogestins. RU486 is one but it has a lot of undesirable sides and is hard to get anyway; not recommended. A good prolactin suppressive drug will help avoid gyno. I would recommend simple vitamin B6. At 200 mg ed, it is a reasonably good prolactin suppressor. If you already have a gyno problem, you can go up to 600 mg ed for a week or two without bad sides. A stronger prolactin suppressor like dostinex (0.5 mg e3d) will do even better but it is significantly more expensive and entails a little more risk. If you take dopamine reuptake inhibitor drugs for depression, I would not recommend dostinex as there might be an interaction I am unaware of.

[beefcake]

Originally posted by spidey
Actually, he had it right in the first place. Anadrol is a potent progestin. It doesn't aromatize so no estrogen is produced.

There actually aren't that many drugs that are true antiprogestins. RU486 is one but it has a lot of undesirable sides and is hard to get anyway; not recommended. A good prolactin suppressive drug will help avoid gyno. I would recommend simple vitamin B6. At 200 mg ed, it is a reasonably good prolactin suppressor. If you already have a gyno problem, you can go up to 600 mg ed for a week or two without bad sides. A stronger prolactin suppressor like dostinex (0.5 mg e3d) will do even better but it is significantly more expensive and entails a little more risk. If you take dopamine reuptake inhibitor drugs for depression, I would not recommend dostinex as there might be an interaction I am unaware of.

What are your thoughts on bromocriptine?

[uridium245]

Bump on the vitamin B6. Might also want to include Vitex at 1500mg per day. It is my understanding that you need 3 ingredients for gyno to develope estrogen, progesterone and prolactin. Block any of those three and gyno should not be able to develop. Based upon the following study Vitex should help as it seems to help block the prolactin receptor not the progesterone receptor as many believe. The second study would also indicate that it binds to one of the two estrogen receptors.

Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications.

Wuttke W, Jarry H, Christoffel V, Spengler B, Seidlova-Wuttke D.

Department of Clinical and Experimental Endocrinology, University of Gottingen, Germany. [email protected]

Extracts of the fruits of chaste tree (Vitex agnus castus = AC) are widely used to treat premenstrual symptoms. Double-blind placebo-controlled studies indicate that one of the most common premenstrual symptoms, i.e. premenstrual mastodynia (mastalgia) is beneficially influenced by an AC extract. In addition, numerous less rigidly controlled studies indicate that AC extracts have also beneficial effects on other psychic and somatic symptoms of the PMS. Premenstrual mastodynia is most likely due to a latent hyperprolactinemia, i.e. patients release more than physiologic amounts of prolactin in response to stressful situations and during deep sleep phases which appear to stimulate the mammary gland. Premenstrually this unphysiological prolactin release is so high that the serum prolactin levels often approach heights which are misinterpreted as prolactinomas. Since AC extracts were shown to have beneficial effects on premenstrual mastodynia serum prolactin levels in such patients were also studied in one double-blind, placebo-controlled clinical study. Serum prolactin levels were indeed reduced in the patients treated with the extract. The search for the prolactin-suppressive principle(s) yielded a number of compounds with dopaminergic properties: they bound to recombinant DA2-receptor protein and suppressed prolactin release from cultivated lactotrophs as well as in animal experiments. The search for the chemical identity of the dopaminergic compounds resulted in isolation of a number of diterpenes of which some clerodadienols were most important for the prolactin-suppressive effects. They were almost identical in their prolactin-suppressive properties than dopamine itself. Hence, it is concluded that dopaminergic compounds present in Vitex agnus castus are clinically the important compounds which improve premenstrual mastodynia and possibly also other symptoms of the premenstrual syndrome.

Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones.

Jarry H, Spengler B, Porzel A, Schmidt J, Wuttke W, Christoffel V.

Klinische und Experimentelle Endokrinologie, Universitatsfrauenklinik Gottingen, Gottingen, Germany. [email protected]

Recent cell culture experiments indicated that extracts of Vitex agnus-castus (VAC) may contain yet unidentified phytoestrogens. Estrogenic actions are mediated via estrogen receptors (ER). To investigate whether VAC compounds bind to the currently known isoforms ERalpha or ERss, ligand binding assays (LBA) were performed. Subtype specific ER-LBA revealed a binding of VAC to ERss only. To isolate the ERss-selective compounds, the extract was fractionated by bio-guidance. The flavonoid apigenin was isolated and identified as the most active ERss-selective phytoestrogen in VAC. Other isolated compounds were vitexin and penduletin. These data demonstrate that the phytoestrogens in VAC are ERss-selective.

[kingj]

i purchased some cabergoline from researchchemist.com and i have been taking that. do you think it should be enough?

[beefcake]

Originally posted by kingj
i purchased some cabergoline from researchchemist.com and i have been taking that. do you think it should be enough?

Cabergoline is dostinex.

[spidey]

Bromo is a dog of a drug. It isn't even FDA approved anymore for hyperprolactemia; but dostinex is.

Bromo is not as well tolerated by the majority of patients and higher dosages must be used to be effective; 2.5 mg ed for bromo or 0.5 mg e3d for dostinex.

Dostinex also has the unintended (but fun) side of increasing labido and making multiple orgasms possible for many men. In fact, the overactive labido is something Parkinson's patients often complain about (go figure..I sure wouldn't complain).

Why would ANYONE use bromo when dostinex (cabergolin) is so readily available? It works better; has fewer undesirable sides; increases labido and sexual pleasure and it is even cheaper than bromo when you take dosage into account.

[ROCKETW19]

Originally posted by spidey
Actually, he had it right in the first place. Anadrol is a potent progestin. It doesn't aromatize so no estrogen is produced.

There actually aren't that many drugs that are true antiprogestins. RU486 is one but it has a lot of undesirable sides and is hard to get anyway; not recommended. A good prolactin suppressive drug will help avoid gyno. I would recommend simple vitamin B6. At 200 mg ed, it is a reasonably good prolactin suppressor. If you already have a gyno problem, you can go up to 600 mg ed for a week or two without bad sides. A stronger prolactin suppressor like dostinex (0.5 mg e3d) will do even better but it is significantly more expensive and entails a little more risk. If you take dopamine reuptake inhibitor drugs for depression, I would not recommend dostinex as there might be an interaction I am unaware of.

well bro i just looked it up in my anabolics book and it says "QUOTE"
estrogenic activity-high
progestational activity-not significant
normaly i would listen to anything you say cuzz i do belive you know your shit but im gonna have to go with MR llewellyn this time

[beefcake]

Originally posted by ROCKETW19
well bro i just looked it up in my anabolics book and it says "QUOTE"
estrogenic activity-high
progestational activity-not significant
normaly i would listen to anything you say cuzz i do belive you know your shit but im gonna have to go with MR llewellyn this time

Everything i've seen says that as well, except this which has me wondering.

Unlike Dianabol, however, it seems that Oxymetholone is progestagenic. It has been observed to cause nipple soreness or to aggravate gynecomastia even in the presence of high dose antiestrogens, strongly suggesting that the effect is not estrogenic.

http://www.premiermuscle.com/forum/showthread.php?t=136

[ROCKETW19]

ya my anabolics book said something like that also but no evidence to back it just a educated guess. but i find it interesting that winny fights of progest. whos the guy that wrote that from premiermuscle is he a knowldgeable guy?

[GreekTank]

Ah.....yes progesterone, otherwise known as the bitch hormone. Take enough B6 as stated above, 500mg/day.