Subcutaneous test shots

[3v1lj03]

I just thought this was interesting.

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Al-Futaisi AM, Al-Zakwani IS, Almahrezi AM, Morris D. Subcutaneous administration of testosterone. A pilot study report. Saudi Med J. 2006;27(12):1843-6.

ABSTRACT

OBJECTIVE: To investigate the effect of low doses of subcutaneous testosterone in hypogonadal men since the intramuscular route, which is the most widely used form of testosterone replacement therapy, is inconvenient to many patients. METHODS: All men with primary and secondary hypogonadism attending the reproductive endocrine clinic at Royal Victoria Hospital, Monteral, Quebec, Canada, were invited to participate in the study. Subjects were enrolled from January 2002 till December 2002. Patients were asked to self-administer weekly low doses of testosterone enanthate using 0.5 ml insulin syringe. RESULTS: A total of 22 patients were enrolled in the study. The mean trough was 14.48 +/- 3.14 nmol/L and peak total testosterone was 21.65 +/- 7.32 nmol/L. For the free testosterone the average trough was 59.94 +/- 20.60 pmol/L and the peak was 85.17 +/- 32.88 pmol/L. All of the patients delivered testosterone with ease and no local reactions were reported. CONCLUSION: Therapy with weekly subcutaneous testosterone produced serum levels that were within the normal range in 100% of patients for both peak and trough levels. This is the first report, which demonstrated the efficacy of delivering weekly testosterone using this cheap, safe, and less painful subcutaneous rout

[Bouncer]

CONCLUSION: Therapy with weekly subcutaneous testosterone produced serum levels that were within the normal range in 100% of patients for both peak and trough levels. This is the first report, which demonstrated the efficacy of delivering weekly testosterone using this cheap, safe, and less painful subcutaneous rout

is this saying that sub-q shots are just as effective as intramuscular?

[coffee-guy]

is this saying that sub-q shots are just as effective as intramuscular?

That's what it says to me...

What I don't understand is the dosing - it would take several sub-q shots to administer the same amount of Test as a typical shot.... :dunno:

[hitmansb]

It doesn't say what base it was in....was it oil? Water? Or was it cyclodextrin, the only carrier base I've every heard of that allows test to be absorbed well sub-q.

[3v1lj03]

is this saying that sub-q shots are just as effective as intramuscular?

At that dose that is the way I read it B. I am not sure if doses higher than these pretty small doses would work the same or not I have not yet been able to find more info if I do I will post it up.

[3v1lj03]

It doesn't say what base it was in....was it oil? Water? Or was it cyclodextrin, the only carrier base I've every heard of that allows test to be absorbed well sub-q.

"Patients were asked to self-administer weekly low doses of testosterone enanthate"

[Bouncer]

i just wish they would be more clear in studies. they always seems to leave out key info no matter what the study.

[3v1lj03]

Here is another abstract I found.

Here is one small study based on test e I found

STABLE TESTOSTERONE LEVELS ACHIEVED
WITH SUBCUTANEOUS TESTOSTERONE
INJECTIONS
M.B. Greenspan, C.M. Chang
Division of Urology, Department of Surgery, McMaster University,
Hamilton, ON, Canada
Objectives: The preferred technique of androgen replacement
has been intramuscular (IM) testosterone, but wide
variations in testosterone levels are often seen. Subcutaneous
(SC) testosterone injection is a novel approach; however,
its physiological effects are unclear. We therefore investigated
the sustainability of stable testosterone levels using
SC therapy. Patients and methods: Between May and
September 2005, we conducted a small pilot study involving
10 male patients with symptomatic late-onset hypogonadism.
Every patient had been stable on TE 200 mg IM for
1 year. Patients were instructed to self-inject with
testosterone enanthate (TE) 100 mg SC (DELATESTRYL
200 mg/cc, Theramed Corp, Canada) into the anterior
abdomen once weekly. Some patients were down-titrated
to 50 mg based on their total testosterone (T) at 4 weeks.
Informed consent was obtained as SC testosterone administration
is not officially approved by Health Canada. T
levels were measured before and 24 hours after injection
during weeks 1, 2, 3, and 4, and 96 hours after injection
in week 6 and 8. At week 12, PSA, CBC, and T levels
were measured however; the week 12 data are still being
collected. Results: Prior to initiation of SC therapy, T
was 19.14+3.48 nmol/l, hemoglobin 15.8+1.3 g/dl, hematocrit
0.47+0.02, and PSA 1.05+0.65 ng/ml. During
the first 4 weeks, there was a steady increase in
pre-injection T from 19.14+3.48 to 23.89+9.15 nmol/l
(p¼0.1). However, after 8 weeks the post-injection T
(25.77+7.67 nmol/l) remained similar to that of week 1
(27.46+12.91 nmol/l). Patients tolerated this therapy with
no adverse effects. Conclusions: A once-week SC injection
of 50–100 mg of TE appears to achieve sustainable and
stable levels of physiological T. This technique offers
fewer physician visits and the use of smaller quantity of
medication, thus lower costs. However, the long term
clinical and physiological effects of this therapy need further
evaluation.

[3v1lj03]

Did I read this right? According to the study, SubQ shots cause higher T levels than IM shots.

This Sub-Q method is apparently becoming quite widespread among TRT patients I read where one doctor is recommending taking the Test Cyp via Subcutaneous Shot in the abdomen.
He claims by doing it this way twice per week you need less Test. It results in more stable test levels & avoids the elevated red blood cell count associated wit I.M. injections. I have not found any studies to support these claims but I am no doctor either.

[hitmansb]

I'm not sure about injecting an oil-based product sub-q, but I can attest to the effectiveness of injecting a base hormone sub-q when it's in a cyclodextrin solution. I used such a product made by a now-extinct Canadian UG lab a couple of years ago, and loved it.

[3v1lj03]

I'm not sure about injecting an oil-based product sub-q, but I can attest to the effectiveness of injecting a base hormone sub-q when it's in a cyclodextrin solution. I used such a product made by a now-extinct Canadian UG lab a couple of years ago, and loved it.

I have spent most of the night reading about guys injecting Sub-q test cyp and test e and they all loved it. I think I may try it after I get done with this cutting cycle.

[Bouncer]

I have spent most of the night reading about guys injecting Sub-q test cyp and test e and they all loved it. I think I may try it after I get done with this cutting cycle.

lol, have fun with that one. interested in the results though. i have a feeling you will have some nice lumps.

[3v1lj03]

Send me a dollar and I will go put in .5 cc right next to my navel right now. Dare me go ahead.:evil:

[Ashop]

Interesting but I'm still not sold quite yet.