prolactin/progesterone help

[rnova43]

Had blood test done and shit doc said my proesterone level was high and there is really nothing i can do it will level out.I need help on what i can do to GET it to level out.

[COLOSSUS]

Iv been meaning to do this test myself but havent had the timeto get my bloodwork done or to do much research on it. All that i know is that cabergoline is a product used to treat progesterone/prolactin gyno but i am not sure on the extent of its abilities to help.

also foghot has said that letro should for both estrogen and progesterone/prolactin problems. i was on it for a bout three weeks before i ran out cause i was running it pretty high and had pretty much no effect on me. maybe its because i was on Epistane which in itself is an anti estrogen compound and possibly cancelled eachother out like iv read that letro and nolvadex do.

do a search on cabergoline and give letro a try.

ill do some research of my own and keep you updated since i am in the same boat as you. hope you will do the same :)

[Bouncer]

Had blood test done and shit doc said my proesterone level was high and there is really nothing i can do it will level out.I need help on what i can do to GET it to level out.

the fact that your doc said "there is nothing you can do." is concerning. there are a number of medications that lower progesterone levels.

one thing to think about is winstrol with your next cycle. winstrol is an anti progestin.


COLOSSUS, the whole letrozole thing is based on the theory that without estrogen, progesterone gyno cannot form. i am pretty sure that theory is false though. i think that by lowering estrogen levels so much you are in fact helping progesterone gyno to form. by that i mean it throws off the estrogen/progestin levels. you lower estrogen and progesterone is left higher.

[COLOSSUS]

COLOSSUS, the whole letrozole thing is based on the theory that without estrogen, progesterone gyno cannot form. i am pretty sure that theory is false though. i think that by lowering estrogen levels so much you are in fact helping progesterone gyno to form. by that i mean it throws off the estrogen/progestin levels. you lower estrogen and progesterone is left higher.

Ya. im gonna have to go get my bloodwork done to make sure it's progesterone. and check my levels.

if it turns out to be progesterone gyno would caber have a similar if not same effect on it that letro has on estrogen gyno?

[Bouncer]

Ya. im gonna have to go get my bloodwork done to make sure it's progesterone. and check my levels.

if it turns out to be progesterone gyno would caber have a similar if not same effect on it that letro has on estrogen gyno?

if your progesterone levels are high i believe the best thing to do is actually come of the letro believe it or not. if the level of estrogen is so much lower then progesterone then the body is left with a surplus of progesterone and boom... progesterone gyno.

[coffee-guy]

First time I ever ran Tren I was running Winny and Proviron with it as well - had NO problems whatsoever...

(B posted a really good article on all the effects of this stuff on estrogen and progesterone alike - wasn't that long ago either - might want to look it up)

Last few times I've run it with just Test I got a little sensitive - the Letro knocked it out for me but idk exactly why/how that was - just worked for ME....

I recommend keeping all things constant and doing what works best for you and your doctor - I have never run more than 500mg's of Test so I know it wasn't that etc......

Good luck bro - just do what is smart/safest for you and always seek the advice of a doctor who is willing to help you - the ones that say there is nothing that can be done should be avoided....

[COLOSSUS]

planning on ordering some dostinex online. iv been reading up on progesterone/prolactin and dostinex. but i wanted to be clear on one area. i know that it will level me it but will it react like letro in terms of somewhat reversing the gyno?

i just realized that m1t is a product that because of the nature of the drug is a prime factor in the creation of prolactin gyno. and now that i think about it i remember that i took this product id say about five years ago (when i wasnt knowledgeable about aas or prohormes etc) without proper pct and all that and after i finished with that product i noticed the puffy nipples etc. that have stayed with me till this day.

also is there a time limit or "expiration date'' to the time when you can treat gyno such as this?

[coffee-guy]

Here...

http://www.superiormuscle.com/forums...s-progesterone

And here....

http://www.superiormuscle.com/forums...w-get-rid-gyno

[COLOSSUS]

rnova. just been reading up a bit. get your hands on some vitamin B-6. its pretty cheap and worth a try.

[3v1lj03]

rnova. just been reading up a bit. get your hands on some vitamin B-6. its pretty cheap and worth a try.

I have had success with B6 and believe it or not Ginkgo Biloba the b6 took care of most of my prolactin problems and I read about the Ginko on another board where they were concerned about a study that indicated B6 could hinder gains while "on" up to 30% I take 100 mg b6 twice a day and Ginko 120 mg per day been happy with it. My nipps are still dark but there is no sensitivity or further signs of gyno and the areola has reduced in size since I first noticed the symptoms. Hope this helps you.

[COLOSSUS]

I have had success with B6 and believe it or not Ginkgo Biloba the b6 took care of most of my prolactin problems and I read about the Ginko on another board where they were concerned about a study that indicated B6 could hinder gains while "on" up to 30% I take 100 mg b6 twice a day and Ginko 120 mg per day been happy with it. My nipps are still dark but there is no sensitivity or further signs of gyno and the areola has reduced in size since I first noticed the symptoms. Hope this helps you.

thanks alot bro. thats the answer iv been lookin for. gonna go to the vitamin shop and pick up both.

[COLOSSUS]

cut-n-paste



PROLACTIN - a patient's guide
Dr Jencia Wong and Professor Ian Holdaway - Endocrinologists


What is it and what does it do?

Prolactin is a hormone. A hormone is a chemical substance, which is secreted by an endocrine gland, and is transported to another part of the body (the "target tissue") where it has an effect. Hormones act at the target tissue by binding to a receptor site on the responding cells. The body's endocrine system uses hormones to convey information and control many of the day to day functions.

Prolactin is produced primarily in the front part of the pituitary gland. This gland is known as the "master gland" because it controls a range of other endocrine organs. The pituitary gland is about the size of a pea and is situated near the middle of the brain.

Prolactin is produced in both men and women. Prolactin is secreted periodically by the pituitary throughout the day and night. The secretion of prolactin is increased by a number of external stimuli including stress, breast-feeding and sexual activity.

In women, the breast is the predominant prolactin target tissue. Prolactin has the effect of stimulating the breast to produce breast milk in late pregnancy and sustaining milk production after birth. To have this effect on the breast, other hormones such as oestrogen also need to be present.

Prolactin is also normally produced in men but appears to have no specific role in males. High prolactin levels have the effect of suppressing the hormones responsible for the normal functioning of the ovaries and testes. High prolactin levels can therefore lead to menstrual irregularity and/or fertility problems.

What controls prolactin production?

A neurotransmitter substance called dopamine controls the release of prolactin from the pituitary gland. Dopamine has the effect of inhibiting the secretion of prolactin from the pituitary gland. Other prolactin releasing factors exist that can stimulate prolactin secretion. These include serotonin and thyroid releasing hormones. The drugs available to treat high prolactin levels either mimic the inhibitory effect of dopamine or block the stimulating effect of serotonin (see under treatment).

How do you know if there is a problem with prolactin?

Prolactin can be measured in the blood. Your doctor may arrange a blood test to check on the blood prolactin level for a range of reasons.

A common reason for measuring blood prolactin is the presence of an unexpected milk-like discharge from the breast. This is a condition known as galactorrhoea. Galactorrhoea can appear in both women and men. Your doctor may also measure the blood prolactin level if a woman has irregular or infrequent periods, or if periods have stopped. Measurements can be done if there has been difficulty conceiving or if there is a suspicion of problems with the pituitary gland.

The prolactin level in the blood is usually 30-600 mIU/l. This value may vary from laboratory to laboratory and is lower in males. If your blood level of prolactin is higher than normal this is known as hyperprolactinaemia.

What causes hyperprolactinaemia (elevated blood prolactin levels)?

Firstly, if the prolactin level is only mildly raised your doctor may simply want to remeasure this again. The stress of the blood test in some people is enough to raise the blood prolactin levels. High prolactin levels are quite normal in pregnancy and if the patient is breast-feeding. Prolactin levels usually return to the normal range within 6 months of the completion of nursing.

Many different types of drugs can elevate blood prolactin levels such as antidepressant medication, opiate drugs and painkillers. Often these medications interfere with the dopamine inhibition of prolactin release. Oestrogen use (as in the use of the contraceptive pill) and the withdrawal of the oral contraceptive pill may also cause a modest elevation in blood prolactin levels in some individuals.

The most important consideration in a patient with hyperprolactinaemia is the possibility of a benign prolactin-secreting tumour of the pituitary gland. This is diagnosed usually by a MRI scan of the pituitary area. Tumours of the pituitary gland associated with hyperprolactinaemia are due to benign over-growths of the prolactin producing cells in the gland. These growths are not malignant or cancerous and either remain stable in size or grow in size very slowly (see below).

Pituitary prolactin producing tumours ("adenomas") are divided into two different "types" by size. Microprolactinomas are the smaller prolactin producing tumours (less than 10 mm in diameter). Macroprolactinomas are the larger prolactin producing tumours (greater than 10 mm in diameter). The larger the tumour, the higher the blood prolactin level so that prolactin levels greater than 6000 mIU/L are usually associated with macroprolactinomas. The exact cause of these tumours is unknown but may be to due some genetic disruption within the pituitary gland.

Macroprolactinomas can grow large enough to interfere with nearby structures such as the nerves from the eyes and other areas of brain function. Rarely, other types of pituitary adenoma can cause hyperprolactinaemia, but not usually to the levels seen in those with macroprolactinomas.

Other medical conditions such as thyroid disease, polycystic ovary syndrome and shingles are also associated with modest degrees of hyperprolactinaemia.

Idiopathic hyperprolactinaemia is the term used for persistently elevated blood prolactin levels for which no cause is found.

What treatment is available for those with symptoms from a raised blood prolactin level?

A raised prolactin level without symptoms, or galactorrhoea without an elevation of prolactin may not necessarily require any treatment as long as the patient is not bothered by it, is menstruating regularly and fertility is not an issue. If the patient is symptomatic, has an absence of periods or wants to conceive, medical treatment (see below) could be considered.

Hyperprolactinaemia and galactorrhoea caused by medication usually responds to the withdrawal of these agents.

If hyperprolactinaemia is due to a pituitary tumour, the choice of treatment depends on the size of the tumour. Microadenomas have an excellent prognosis and do not need treatment if the patient is symptom free, menstruating regularly and fertility is not an issue. There is little evidence that these microadenomas progress to become macroadenomas. These patients need to have regular blood prolactin measurements and probably follow-up pituitary scans to ensure that the tumour does not grow (although this is unlikely).

Prolactin secreting macroadenomas usually need treatment as they may, on occasion, threaten vision and cause other pressure effects within the brain. Tablet treatment (as opposed to surgical treatment) is the management of choice. Such medical treatment can shrink these tumours and control their growth, and there is a high response rate. Several drugs are now available for this purpose. If medical treatment is unsuccessful, pituitary surgery can be considered.

Medical treatment

Dopamine agonists

This group of drugs act like naturally occurring dopamine to inhibit the secretion of prolactin from pituitary cells.

Bromocriptine

This has been used as a prolactin-suppressing agent since the 1970s. This is usually given as 1.25 mg (half a tablet) at bedtime for the first week. This is the treatment of choice for the treatment of prolactin-related infertility, as it is considered to be relatively safe in pregnancy. This dose can be increased slowly to a dose of 2.5 - 5 mg given twice a day with food to minimise side effects. Side effects include dizziness on standing (due to low blood pressure), nausea, and nasal stuffiness. Caution should be taken if taking other medicines for treatment of high blood pressure.

Lisuride

This is an alternative to bromocriptine and acts in a similar way. Again, low doses starting slowly should limit side effects. The starting dose is 0.1 mg daily increasing slowly after 1-2 weeks to a standard dose of 0.2 mg three times daily.

Cabergoline

This is very similar to bromocriptine but is longer acting with fewer side effects. If bromocriptine or lisuride are not suitable then this is a reasonable alternative. It is more expensive than the other agents and in New Zealand needs to be prescribed by a specialist. Experience with this drug in pregnancy is limited but appears safe in general experience to date.

Quinagolide (CV 205-502)

This is a second line treatment more potent then bromocriptine and is available on specialist recommendation only. It is used for those intolerant of bromocriptine-like medications.

Serotonin Antagonists

Serotonin acts to stimulate prolactin release. Serotonin antagonists act by blocking this effect of serotonin on prolactin secretion.

Metergoline

A serotonin antagonist with a short duration of action. This is no longer listed for use in New Zealand.

How can one tell if the treatment is working?

Treatment can be assessed by noting the restoration of menstrual periods, resolution of galactorrhoea, tumour shrinkage as assessed by scanning, and blood prolactin levels. Fertility may be restored even before menstruation occurs. If pregnancy is not desired then appropriate precautions need to be taken once treatment for raised prolactin begins.

[Ashop]

Had blood test done and shit doc said my proesterone level was high and there is really nothing i can do it will level out.I need help on what i can do to GET it to level out.

do some searches on bromocriptine and/or Dostinex

[3v1lj03]

I forgot I also pop an extra b6 as much as I can remember to every time I have sex. IF you look into it you will see that is a big time prolactin/ progesterone release and it was symptoms at post "o" that led me to diagnose my problem.

[COLOSSUS]

I forgot I also pop an extra b6 as much as I can remember to every time I have sex. IF you look into it you will see that is a big time prolactin/ progesterone release and it was symptoms at post "o" that led me to diagnose my problem.

did really understand what you said haha

but yea b6 and ginko both help regulate prolactin