Along the same lines of Adequan (PSGAG), I have been using intramuscular Sodium Hyaluronate with very good success.
PSGAG is a technical marketing term to describe what we all know as chondroitin sulphate. Chondroitin can have a sulphate ester attached at several positions on the molecule, 4 or 6 or a disulphate at 4 and 6. Hence the terms POLY (many) Sulphated and Glycosaminoglycan (which in this case is chondroitin).
Adequan is patented for a specific ratio/blend of 4 sulphate to 6 sulphate ect., to protect the exact product formulation. The position of the sulphate doesn't matter to the body however, it only matters to the lawyers.
Sodium Hyaluronate is the only nonsulphated glycosaminoglycan, (glucosamine is also in the glycosaminoglycan family). Sodium Hyaluronate is the sodium salt of hyaluronic acid, the only rate limiting chemical that makes up the proteoglycan molecule that provides the cushoning effects of synovial fluid amoung other aspects of cartilage protection. SH provides the back bone to which the other molecules attach (proteins, chondroitn, glucosamine etc)
Both PSGAG and SH are excellent products, both are water based solutions so IM injection is easy and generally pain free. The final thing that both of these product have in common is that they are not available systemically (read IM administration) for humans (WTF)!!! Freaking horses and dogs have better access to injectable joint supplementation than humans do. We have to wait to see and Orthopod and at best he/she might inject SH into the joint capsule possibly with cortisone! This needs to change!
PSGAG is a technical marketing term to describe what we all know as chondroitin sulphate. Chondroitin can have a sulphate ester attached at several positions on the molecule, 4 or 6 or a disulphate at 4 and 6. Hence the terms POLY (many) Sulphated and Glycosaminoglycan (which in this case is chondroitin).
Adequan is patented for a specific ratio/blend of 4 sulphate to 6 sulphate ect., to protect the exact product formulation. The position of the sulphate doesn't matter to the body however, it only matters to the lawyers.
Sodium Hyaluronate is the only nonsulphated glycosaminoglycan, (glucosamine is also in the glycosaminoglycan family). Sodium Hyaluronate is the sodium salt of hyaluronic acid, the only rate limiting chemical that makes up the proteoglycan molecule that provides the cushoning effects of synovial fluid amoung other aspects of cartilage protection. SH provides the back bone to which the other molecules attach (proteins, chondroitn, glucosamine etc)
Both PSGAG and SH are excellent products, both are water based solutions so IM injection is easy and generally pain free. The final thing that both of these product have in common is that they are not available systemically (read IM administration) for humans (WTF)!!! Freaking horses and dogs have better access to injectable joint supplementation than humans do. We have to wait to see and Orthopod and at best he/she might inject SH into the joint capsule possibly with cortisone! This needs to change!

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