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  • Liquid S4

    I wanted to know if anyone can clear this up for me? I read an article where "Andarine" was given the synonym of S4, but everyone believes it is actually "Ostarine". Which one is it? Andarine is supposed to be less potent. I was thinking of trying out the Liquid S4 and I wanted to get some more information before purchasing the product. Especially since it will last only 30 days or less at $139. By the way, I have been using Clen for 10 days while on PCT. Seems to help keep my workouts more upbeat and intense. Would it cause any problem to run S4 alongside of Clen or even shortly after it's cessation? My last question is, Clen was reported to have some negative effect on the natural rhythm of your metabolism over time. Is this founded? I will be tapering off, using the 2 week on, 2 week off protocol. If necessary, I will abandon it's use all together and continue with my diet and exercise regime which has never failed me.
    Last edited by estone41; 04-04-10, 11:20 AM.

  • #2
    Andarine
    From Wikipedia, the free encyclopedia
    Jump to: navigation, search
    Andarine
    Systematic (IUPAC) name
    (2S)-3-(4-acetamido-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide
    Identifiers
    ATC code none
    PubChem 10201099
    Chemical data
    Formula C19H18F3N3O6
    Mol. mass 441.357 g/mol
    SMILES eMolecules & PubChem
    Therapeutic considerations
    Pregnancy cat. ?
    Legal status Investigational new drug

    Andarine (S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTx Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy,[1] using the non-steroidal androgen antagonist bicalutamide as a lead compound.[2]

    Andarine is an orally active partial agonist for androgen receptors. It is less potent in both anabolic and androgenic effects than other SARMs. In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects.[3] This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH.[4]

    Clinical development of Andarine has been abandoned, given in humans it results in a series specific toxic metabolite [5].

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    • #3
      I used this stuff at 50mgs per day and noticed an near immediate increase in strength. The only side that I noticed was lethargy after taking a dose.

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      • #4
        Originally posted by liftsiron View Post
        I used this stuff at 50mgs per day and noticed an near immediate increase in strength. The only side that I noticed was lethargy after taking a dose.
        same - minus lethargy, had difficult with night vision but that went away.

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        • #5
          What about muscle building properties? Did you guys notice any gains worth mentioning? I would like to use it mainly to decrease catabolism while dieting and losing fat.

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          • #6
            I was keto when I was taking it and strength endurance and muscle retained to the best of my knowledge, only changes i saw were good.

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            • #7
              Thanks. That's what I wanted to know.

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              • #8
                best thing I can compare it too is prop, but I only have used prop once - it's not like var, pumps aren't the same - but the endurance / strength feel like prop and body composition during use was noticeable.

                Split your dose 25mg am - 25 mg before lifting - shit you not 30 minutes after taking it I would be ready to fight for sparta, dunno if it was all in my head but the stuff really works.

                Also - me n COLOSUSS both had mild acne , and neither of us had had probs w/aas and acne before.

                good luck brother, I'm about to start running some of it myself =)

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                • #9
                  What about hormone levels? Does it seems to hinder natural test production or is it not very likely?

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                  • #10
                    Originally posted by estone41 View Post
                    What about hormone levels? Does it seems to hinder natural test production or is it not very likely?
                    The entire point of it for more was that I could run it without shutting down - bridging / pct - this time I'm adding it with my cycle. So I'm real interested to see how that goes, I'm on a long cycle, and trying to see how certain compounds respond.

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                    • #11
                      That's right. You did mention SARMS with PCT. My bad. I plan on buying some this week. Eager to see what it can offer over the short term. It will be at least another month and a half before I go another round.

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                      • #12
                        Good luck bro - the 25mgx2 split has worked well for everyone I know who has run it. That's my best suggestion. You'd be the first to be dissapointed by it if you did not like it, let me put it that simply. :) Keep up to date with results, always good with the RC to know how everyone is responding esp with there diet / training / goals .. etc.

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                        • #13
                          Originally posted by the art of war View Post
                          same - minus lethargy, had difficult with night vision but that went away.
                          What type of vision issues and this was on 50mg daily?

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                          • #14
                            Originally posted by Alin View Post
                            What type of vision issues and this was on 50mg daily?
                            I had to stop lifting @ night, I'd have trouble adjusting to dark and light - it wasn't awful but it was risky to drive at night, car lights were tough and since they are staring at you everywhere it became like driving drunk. That stopped 3 days after I stopped using. I know a few other ppl had eye problem but vast majority haven't that i've talked too about it, and it's a RC I am a huge fan of.

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                            • #15
                              thanks, great info on sarms, very excited to start a sarms cycle.

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