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posted by captainbicept on WCBB
Vitamin D is an Anti-E
Vitamin D is only anti-estrogenic where it’s needed
It just keeps on coming – positive news from scientists about vitamin D. According to an animal and cell study that endocrinologists at Stanford University published in Endocrinology, the active form of vitamin D – calcitriol [structural formula shown below] – is an anti-oestrogen. The study is interesting for bodybuilders too, as the anti-estrogenic effect of vitamin D is expressed mostly in the fat tissue. What’s more, vitamin D enhances the effect of anti-oestrogens like arimidex, letrozole and exemestane.
Calcitriol
The researchers want to know whether dietary changes can reduce the chance of breast cancer in women and improve treatment chances in women who already have breast cancer. Estradiol often causes breast cancer cells to grow faster. So doctors treat breast cancer with drugs that reduce the concentration of estradiol. The researchers already knew that vitamin D blocks the production of the alpha-estradiol receptor, and wondered whether vitamin D also reduces the production of estradiol itself. That would happen by inhibiting the enzyme aromatase, which converts androstenedione and testosterone into estradiol.
To answer this question the researchers did trials with female mice that had had human cancer cell implants. The mice were given 0.1 mg androstenedione daily, and for the three days before the researchers analyzed them they were given a daily injection of 0.75 mg calcitriol as well. [Cal] A control group was given injections containing inactive ingredients. [Veh] The figure below shows that the cancer cells and the fat cells of the Cal mice produced less aromatase.
Vitamin D is only anti-estrogenic where it’s needed
__________________
Vitamin D is an Anti-E
Vitamin D is only anti-estrogenic where it’s needed
It just keeps on coming – positive news from scientists about vitamin D. According to an animal and cell study that endocrinologists at Stanford University published in Endocrinology, the active form of vitamin D – calcitriol [structural formula shown below] – is an anti-oestrogen. The study is interesting for bodybuilders too, as the anti-estrogenic effect of vitamin D is expressed mostly in the fat tissue. What’s more, vitamin D enhances the effect of anti-oestrogens like arimidex, letrozole and exemestane.
Calcitriol
The researchers want to know whether dietary changes can reduce the chance of breast cancer in women and improve treatment chances in women who already have breast cancer. Estradiol often causes breast cancer cells to grow faster. So doctors treat breast cancer with drugs that reduce the concentration of estradiol. The researchers already knew that vitamin D blocks the production of the alpha-estradiol receptor, and wondered whether vitamin D also reduces the production of estradiol itself. That would happen by inhibiting the enzyme aromatase, which converts androstenedione and testosterone into estradiol.
To answer this question the researchers did trials with female mice that had had human cancer cell implants. The mice were given 0.1 mg androstenedione daily, and for the three days before the researchers analyzed them they were given a daily injection of 0.75 mg calcitriol as well. [Cal] A control group was given injections containing inactive ingredients. [Veh] The figure below shows that the cancer cells and the fat cells of the Cal mice produced less aromatase.
Vitamin D is only anti-estrogenic where it’s needed
__________________
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