anyone got experiance with this stuff? I mean without using other compounds at the same time.I was thinking of using 50 mg/ed after my next cycle that will consist of 500 mg test E for 16 weeks:40 mg dianabol/ed for 5 wks.200 mg tren e /wk for ten weeks.also 300mcg of ghrp6 from now on.
Announcement
Collapse
S4
Collapse
X
-
I've used 3x now - off , on , and stand alone w/var
50 - 25 am / 25 pm - I'll vouch for my love of SARMs day and night.
Pros: Endurance - off the fucking charts, off on, whatever - you will be ready to go in the gym for hours.
Strength - not as strong as test boost but certainly increase.
Size - with hard dieting I gained 1-2 lbs of legit muscle while off , while on forget it I can't tell how much is worked w/the cycle honestly , w/var alone put on 5lbs in 30 days.
cons: Night vision - I really was a liability at it's peak with the night vision problem, but I know MANY people who have no problems , I think it just is my body is more prone.
Acne - never before seen anything break me out faster , I got it under control but the shit made me look like a dart board on my back first time around when I didn't know shit and was the lab rat.
- like i said, ill vouch for SARMs all fucking day and night in any situation on off bridge -
Comment
-
imo with the pricing of it now there is zero reason not too.
I've talked to a few guys and I'm trying to see where they go with SARMs , but we've been tossing around ideas to make the most affective use of it in cycle. Everyones goals are different so it's difficult, some people want it instead of using a more androgenic steroid, some want to pair it up. I'm not even sure frankly how I want to use it! But i will!
Comment
-
honestly - I've read that it can hinder gains on cycle because it could block receptors , and I've read it will basically hold hands and help a steroid's affectiveness. I don't know of one particular article I read that I can quote and say, yea that's right all over. This is from use and understanding.Originally posted by THE BOUNCER View Posthow exactly do sarms work? anyone have any goof articles to post?
Comment
-
SARMS is the latest addition to the enhanced athletes arsenal and it’s creating a storm of controversy. It may very well be most significant advancement in muscle development since the invention of Dianabol back in 1956. A bold statement for sure. But SARMS is truly an incredible compound with many applications, most significantly, as a viable anabolic enhancement to be used in-between steroid cycles.
SARMS is not a steroid. It is the veritable “next step” beyond steroids. It’s a Selective Androgen Receptor Modulator, which essentially means it targets the androgen receptors in a way where they’re most beneficial while avoiding the nasty side effects that go along with traditional androgenic drugs.
Due to that elusive combination of good without the bad, SARMS has been hailed as the “Holy Grail of Muscle Growth.” It’s what all athletes have been waiting and wishing for. Think of it as pizza without calories, alcohol without the hangover and safe sex without condoms. Is that possible? Yes it is. But there are limitations. (Damn!) But rest assured, they’re minor. There is a catch – there always is. But in the case of SARMS, the catch isn’t that bad.
For one thing, SARMS will not work like mega doses of steroids. You would not be able to take supraphysiological dosages in order to gain massive size on the order of a gram of testosterone. Its benefits work within a specific dosage range . In that regard, SARMS is unique. A good comparison would be to aspirin, which will always lower a temperature from a fever, but no lower than 98.6. However, MORE aspirin will not improve the condition. There’s that “sweet spot” where it works its magic with virtually no risk. SARMS is like that. In controlled dosages it’s a non toxic, non suppressive compound that works like steroids, but without the side effects. But beyond a certain dosage, it doesn’t work much better. It’s a sort of “built in safety net.” 50ml a day is an effective dosage with 100mls a day being the cut-off point to avoid any negative side effects.
The potential and the possibilities are as compelling as they are enticing, but one area where SARMS is becoming increasingly popular is in the area of “bridging.”
A “bridge” is essentially a description of using any compound that will maintain the gains of the former cycle on through to the next cycle, months later. How to best do that has been a controversial topic for some time. In the past, bodybuilders have attempted to sustain the effects of a steroid cycle by using a milder , less suppressive steroid (such as Primobolin) in-between cycles. Another method of attempting a “bridge” was to use a short acting oral in the A.M so that it would not be active past a four hour window. In this way one may (theoretically) recover over-night, resulting in the body managing to restore its natural hormonal balance. Unfortunately, neither game plan was especially successful for even a low dose of any steroid will cause suppression and hinder recovery. But remember, SARMS isn’t a steroid. It works on an entirely different principle – that of being “selective” to muscle. And at 50 mls a day it’s been shown to have no suppressive effects. (Unless dosing exceeds several months). This makes SARMS the perfect choice to be used in-between cycles. You won’t make massive gains while on but you’ll hold onto your gains and still be in an “enhanced” state without fear of suppression. Not a bad deal.
It would make far more sense to “bridge” using SARMS on its own, or with natural supplements in order for the body to maintain ultimate anabolism without suppression. As much as using a less suppressive steroid may seem to make sense, ANY steroid even in low dosages will suppress, delay recovery, and ultimately work against the process of recovering from a cycle. It will also minimize the results of the NEXT cycle since the receptors would not have had a chance to replenish. This is what makes SARMS superior for this purpose.
Another similar method that’s becoming popular is to use SARMS as a “mini-cycle” in-between steroid cycles. In other words, once you finish your course of steroids and do a proper PCT and settle into being “natural”, after a while you can use SARMS daily for a 4 week run. In this way you can bump up gains, increase muscle density, improve lifts and burn fat – all without deregulating androgen receptors or compromising the HPTA. (Hypothalamic Pituitary Testicular Axis). Never before has this been possible.
A PCT following a SARMS cycle may not be necessary. Some OTC supplements may be all you need to get back to baseline. SARMS won’t aromatize so there’s no fear of developing gyno or other estrogen related conditions.
SARMS has many uses and having an anabolic/androgenic advantages while off cycle may be the most significant of all.
Comment
-
SARMS S-4 is a revolutionary advancement in the field of muscle development through anabolic enhancement. Simply put, SARMS targets the androgen receptors in a “selective” manner (Hence the term Selective Androgen Receptor Modulators), zeroing in on the “good “ aspects while negating the bad(1). In this way, you get the benefits of enhanced androgenic effects – strength, increased muscle and heightened libido – without the negative side effects of traditional anabolic/androgenic steroids -- prostate enlargement(2), increased blood pressure, testicular atrophy, hair loss and elevated cholesterol(3)(4). And it does it all in an orally bio-available form that is not liver toxic. Sound interesting? It should. SARMS is changing the landscape of bobybuilding in a big way. And for those who already use steroids as a part of the process, SARMS has several interesting applications, most significantly, in the area of Post Cycle Therapy(5).
Part of this usage is another advantage that is especially appealing to those who use steroids on a regular basis. In controlled dosages, SARMS is relatively non-suppressive. This opens up considerable possibilities in regard to utilizing SARMS to enhance a typical steroid cycle, but more significantly, it becomes a tremendous tool in the area of PCT.
Coming off of steroids is the most complicated, and often confusing part of the process. The athlete wants to maintain gains, avoid the “crash” of reduced strength and muscle growth and yet, recover his natural hormonal balance. It’s a tricky balance of drugs, supplements and ultimately luck. Some fare better than others and many consider the down time inevitability. But with the advent of SARMS S-4, not only can the transition be made more tolerable, it is now possible to avoid the down sides of coming off of a steroid cycle(6). One can maintain the gains and even continue growing after the cessation of steroids.
The most logical method of PCT use would be to implement SARMS as a “taper” at the end of a cycle. In other words, once you stop using steroids, the body can obviously no longer support the muscle growth it achieved in an enhanced state. Natural testosterone is lower. And nitrogen retention is lessened. That’s where SARMS fits the bill. By using SARMS following the end of a cycle, the body can begin to recover yet still receive both the anabolic and androgen benefits. Muscles will still be able to absorb increased nitrogen from protein sources, thus increasing muscle tissue growth and the androgenic qualities will insure that strength is maintained(7). Recovery time will also be reduced. You can still work out hard without fear of overtraining and the increased workload will lead to further improvement. In short, this means no crash and no loss of gains. Essentially, you’re still “on” but you’re recovering. Sounds perfect, doesn’t it? Well, it’s not perfect, but it’s pretty damn close to it. Never before has anything like this been possible and the potential is amazing(8).
The only drawback of using SARMS (if it even be considered a drawback) is the fact that its androgenic ratio is closer to a mild steroid such as Primobolin than it is to testosterone. So by itself, one could not and should not expect tremendous gains in mass from it. Increasing the dosage beyond 50-100 mls a day is not recommended since at that point the risk/benefit ratio shifts unfavorably – not that the side effects are severe, but that’s where continued use could lead to suppression, and then you’re defeating the purpose of using it for PCT(9)
Another steroid with which SARMS can be compared is Proviron. The main similarity in regard to the physical result is a noticeable “hardness” and increased density to the muscles. Proviron is also only mildly suppressive and then, only in high dosages for extended duration, which is why it too is a popular add-on at the end of a cycle. Neither drug can aromatize and also work as an anti estrogen. (Another advantage in PCT). The main difference between Proviron and SARMS is that Proviron is DHT based making it especially hard on the hairline and prostate -- NOT what you want when trying to restore sex drive and stamina. SARMS has been shown to cause less prostate hypertrophy than all other steroids(10). In fact, in some studies SARMS has been shown to decrease prostate weight similar to the 5 alpha reductase inhibitor, Finesteride(11). How perfect is that?
Higher dosages have also been shown to lead to vision disturbances (much like with Clomid). Still, at 50mg - 100mg a day the results are impressive and virtually side effect free. A good way to incorporate SARMS into PCT is to begin using 50mls a day at the same time as you begin using other PCT ancillaries – depending on what drugs and supplements you prefer and/or found to be effective. You then can continue using SARMS and supplements which will allow the HPTA to begin functioning on its own without the help of other drugs such as HCG or Clomid(12). The added benefit would be continued strength and libido and an increased muscularity. Instead of being a time when you experience the loss of gains, it will become a time when the gains become solidified and you can look better than ever(13).
It won’t be long before the term PCT and SARMS are inexorably linked. The way PCT is conducted will be changed forever. In fact, it already is.
REFERENCES.
1.Drug Discov Today. 2007 Mar;12(5-6):241-8. Epub 2007 Feb 7.
Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs).
Gao W, Dalton JT.
Division of Pharmaceutics, College of Pharmacy, The Ohio State University, 500 W 12th Avenue, Columbus, OH 43210, USA
2.Expert Opin Investig Drugs. 2006 Apr;15(4):377-87.
Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery.
Segal S, Narayanan R, Dalton JT.
1GTx, Inc., Memphis, TN 38163, USA
3.Curr Opin Investig Drugs. 2006 Oct;7(10):873-81.
Selective androgen receptor modulators: in pursuit of tissue-selective androgens.
Omwancha J, Brown TR.
Johns Hopkins Bloomberg School of Public Health, Department of Biochemistry and Molecular Biology, Division of Reproductive Biology, 615 North Wolfe Street, Baltimore, MD 21205, USA
4.J Biol Chem. 2009 Dec 25;284(52):36367-76. Epub 2009 Oct 21.
Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands.
Schmidt A, Harada S, Kimmel DB, Bai C, Chen F, Rutledge SJ, Vogel RL, Scafonas A, Gentile MA, Nantermet PV, McElwee-Witmer S, Pennypacker B, Masarachia P, Sahoo SP, Kim Y, Meissner RS, Hartman GD, Duggan ME, Rodan GA, Towler DA, Ray WJ.
Department of Molecular Endocrinology/Bone Biology, Merck Research Laboratories, West Point, Pennsylvania 1948, USA
5.Nucl Recept Signal. 2008;6:e010. Epub 2008 Nov 26.
Selective androgen receptor modulators in preclinical and clinical development.
Narayanan R, Mohler ML, Bohl CE, Miller DD, Dalton JT.
Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, USA
6.Handb Exp Pharmacol. 2010;(195):99-126.
Synthetic anabolic agents: steroids and nonsteroidal selective androgen receptor modulators.
Thevis M, Schänzer W.
Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany
7.Pharmacokinetics of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide in rats, a non-steroidal selective androgen receptor modulator
J. D. KEARBEY,† D. WU,† W. GAO,† D. D. MILLER,‡ and J. T. DALTON†* †Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
‡Department of Pharmaceutics, Graduate Health Sciences Center, College of Pharmacy, University of Tennessee, Memphis, TN 38163, USA
8.J Clin Endocrinol Metab. 1999 Oct;84(10):3459-62.
Selective androgen receptor modulators (SARMs): a novel approach to androgen therapy for the new millennium.
Negro-Vilar A.
Ligand Pharmaceuticals, Inc., San Diego, California 92121, USA
9.Discovery and biological characterization of a novel series of androgen receptor modulators.
Zhou C, Wu G, Feng Y, Li Q, Su H, Mais DE, Zhu Y, Li N, Deng Y, Yang D, Wang MW
10.Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators.
Marhefka CA, Gao W, Chung K, Kim J, He Y, Yin D, Bohl C, Dalton JT, Miller DD
11.Antiandrogens in prostate cancer.
Reid P, Kantoff P, Oh W.
Lank Center for Genitourinary Oncology, Dana Farber-Partners Cancer Care, Boston, MA 02115, USA
12.Emerging drugs for hypogonadism.
Edelstein D, Dobs A, Basaria S.
Johns Hopkins University School of Medicine, Division of Endocrinology and Metabolism, Baltimore, MD, USA
13.Anabolic applications of androgens for functional limitations associated with aging and chronic illness.
Bhasin S, Storer TW
Comment
-
It only lasted for 2-3 days max after I was off brother - just don't do a lot of night driving lol, I had some blurry drives too and from PM cardio at the time.Originally posted by Alin View PostThe only reason I havent used it is the vision issues. My vision isnt 100% already and I dont need something hindering it worse. I do believe that side is dose related.
Comment

Comment