How many AS can one make from 1-test.......

[martialartist11]

I was thinking about starting with cholesterol and treating with the Jone's Reagent (CrO3, acid,) heating, and isolating the andro by dissolving the cholesterol in acetone and hooking up a condenstion apparatus to catch the acetone on the far side. I'm thinking this oxidation makes a green mess for a product. My question is how would one isolate the andro and how much Jone's reagent is needed. Thanks

[spidey]

I believe I have an old reference for doing that reaction. I don't have time to find it right now but I will post it when I get back from Maine next week. Happy Thanksgiving to all.

[GIJoe]

Saw a chemical reaction for DHEA to Test base, but cannot find it (old patent, I think). How likely does it sound? They used some kind of fermentation process, I believe, involving yeast, a sugar, and don't remember the solvent, in an O2 atmosphere; constant agitation for around 1 week. Does this sound correct, or is there a better way to convert?

[spidey]

It could be. You need to install the double bond and oxidize the 3-OH. A nice little fermentation with yeast and suger would be an ideal way to do it if you can find the reference. No toxic solvents or reagents and no fire hazards etc. Just ingredients you can pick up at the grocery store and water as solvent.

[MADMAX23]

hi , I have a question to spidey , I want to make boldenone propionate from testosterone propionate , I was thinking in:

1: Hidrogenation C4-C5 (using hidrogen catalized by platinium dioxide)
2nd y 3rd: Bromination C1 and C4(using Bromo (Br2) in acetic acid, then Bromihidric acid (HBr) in acetic acid)
4: making doubles bonds in C1-C2 and C4-C5 using pyridine.

another alternative is using SELENIUM DIOXIDE SeO2 or DDQ in Benzoic acid in Toluen reflux...
tell me what you think about this please.

[spidey]

No need to hydrogenate the 4-5 double bond. You need that bond in the finished product anyway. Why remove it only to re-install it later?

Look at the initial post. Test prop could be substituted with 1-test cyp. The 2,4,4,6-tetrabromocyclohexa-2,5-dione would cleanly install a Br on the 2 position and then elimination by stirring in neat DBU for 20 minutes or so would give you good yields of boldenone prop. If you can get PtO2 and bromine, you should be able to get 2,4,4,6-tetrabromocyclohexa-2,5-dione. It is also much less expensive than PtO2.

If you are working from a set list of reagents (i.e. can't order anything but are working in a moderately well stocked lab), you can form the diene-enolate by treating test prop with a strong base like LDA or lithium bis(trimethylsilyl)amide in ether or THF at -78 deg for 45 minutes and treating this enolate with bromine. This will give you the 2-bromo test prop as well but the yield will likely be in the 60's or low 70's. You can increase this yield by generating the enolate under amine free conditions but that is a little more work and may not be worth it to you time wise.

BTW, pyridine isn't basic enough to effect the elimination of bromide anyway. You need a stronger base like DBU. The classic was to eliminate Br is to reflux in DMF with lithium carbonate/lithium bromide. This would give high yields as well.

If you insist on your route, you need a less powerful hydrogenation catalyst. Pa (10% on carbon) would be better.

[spidey]

Oh yeah, stay away from SeO2. Very toxic and wouldn't give you good yields anyway probably.

DDQ MIGHT work. You could try it on small scale just to see. If it worked, that would certainly be an easy way to do it.