Bouncers MK-677 (Ibutamoren) Log

[Bouncer]

Bouncers MK-677 (Ibutamoren) Log

I saw Turbos log and conclusion but it was a bit lazily done IMO.. sorry Turbo. :grin: I feel that if it's anything like real GH it will have very subtle results and only someone who has real GH experience will be able to compare. I've seen a few logs with people running MK-677 and people get the same sides as GH (water retention, numb swollen hands, tired feeling etc..) but for some reason people expect to see steroid like results within a month or 2. This is NOT how real injectable GH works so why would MK-677 work any differently?

I will be running 25mgs first thing in the morning with a 5 day on 2 day off schedule. Apparently there is some resistance seen around the 4th-5th day that can be reversed by simply coming off for 2 days.

I will give MK-677 a full 3 months test and give it the time to do its thing. I will update weekly every Monday morning so be sure to check back.

[Bouncer]

Should be noted that I'm running this drug for more then just vanity. Iv'e been having some soft tissue/tendon/joint issue on my left shoulder/spine area. The hope is the increased water retention/igf-1/GH will help a little with repair. Not expecting a miracle but even a small improvement would be welcomed.

[Bouncer]

For those that don't know what MK-677 is:

Ibutamoren (INN) (developmental code names MK-677, MK-0677, L-163,191) is a non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including GH and insulin-like growth factor 1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity.

http://press.endocrine.org/doi/full/...jcem.83.2.4551

"A total of 416 patients completed treatment and assessments at 12 months. Administration of MK-677 25 mg resulted in a 60.1% increase in serum IGF-1 levels at 6 weeks and a 72.9% increase at 12 months" Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial. - PubMed - NCBI

"MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism." MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. - PubMed - NCBI

Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women. Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral den... - PubMed - NCBI

[chuckz28]

Interesting. Been a while since doing something other than test right? I'll be interested to see what you think of it. When do you start?

[Bouncer]

Yea that's the thing. All the logs I've seen are people running all kinds of other shit and they have no idea whats doing what.

I eat the same shit every single day and I run the same test dose (300mgs E4D) and have been for months. So I will for sure be able to tell if or when the MK-677 has even a small effect.

Should be here on Saturday so that's when I'll start.

[MattG]

Good stuff. Looking forward to the log bro

[Turbo3000]

Hopefully you will like the results.

[AvidFisherman]

I'm pretty interested as well, gh results for a fraction of the cost?

[Bouncer]

I will answer that for you in the months to come. If its anything like the real gh I've used I will be very surprised.

[ROCKETW19]

I'm pretty interested as well, gh results for a fraction of the cost?

come on really. not even close bro. of anyone claims that there full of shit.

bouncers log will be our best knowledge like he said its same ting everyday not 15 drugs ect. he will see what changes.

I just started running serostim again yes its retarded money but i am old I need the tendon repair along with all the other great things it will do for old fucks.

its gonna be proven one day that there is something the chineese put in there fake GH to give you sides of real GH. for all i know this is it? But ill tell you hundreds of people take GH get the sides just like real GH. they take serum test they come out high. BUT and the BUT when they take the real test IGF 1 it comes out with a fat ZERO.
that tells you they have something very good to trick the newbie. no offense to any of you but none of you know what real GH is besides Bouncer

I have been yelling at other private boards for years fuck your serum test do IGF test thats what counts. i doubt it was me as to why they finally did but they do and thats all that matters.
a lot of well know sources prob very upset. but I just hope they didn't know better and just sold it. if they did know they should be shot IMO.

[BamBam179]

Solid, can't wait for the updates

[Bouncer]

its gonna be proven one day that there is something the chineese put in there fake GH to give you sides of real GH.

haha, i been thinking this for awhile. if people only knew what Jintropin circa 2003-2004 felt like..

the hyges i ran in 2012 was for sure real GH but it never hit the level of those Jins from 2004.

yea im not expecting much from the MK-677 but I will be interested to see if there are similarities.

i have nothing to gain from saying it's good, none of our sponsors carry MK-677 so if it worthless crap I'll be sure to post it without issue.

[Bouncer]

Fountain of Youth: Drug Restores Muscles

[Bouncer]

DAY 1

Started today. Tasted like shit. lol

I'll update when there is something interesting to report.

I have enough to run for 3 months and I'll run it till it's finished. By the end of this log I'll tell you fuckers if this shits worth it or not. I've read so many logs on this stuff and there never seems to be an absolutely clear answer on this stuff. I will give a clear answer. No placebo effect here.

[Bouncer]

More info.

Mk-677 is an orally administrated growth hormone secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete growth hormone. In other words, Mk-677 could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn’t require any injections nor does it have any side effects like GHRP-6. This GHS (Growth Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.

Growth hormone pulse intensity can be increased through 4 possible mechanisms:

Increasing GHRH (growth hormone releasing hormone) release.
Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
Reducing somatostatin release (somatostatin turns off GH release).
Inhibiting of somatostatin receptor signaling.

Mk-677 was found to work through all four of these mechanisms. After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.

In a study on it’s effects on catabolic states, a once daily oral dose of 25mgs was given to healthy young men subjected to short-term diet-induced nitrogen wasting. After 7 days of this dose, the subjects showed a sustained increase in serum concentration of IGF-1 and Growth Hormone; in addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting.

Trials testing the effects of this GHS on fighting obesity showed an increase in lean body mass, but neither total, nor visceral adipose tissue was effected. This study gave subjects 25mgs of MK-677 per day for 8 weeks. The subjects showed an increase in basal metabolic rate after 2 weeks, and an increase in serum levels of GH, IGF-1 and IGF-1 binding protein-3. Increase in lean body mass was hypothesized to be caused by an increase in calorie deposition into the muscle and appetite decrease as opposed to reducing fat storage directly.

A study done for the treatment of osteoporosis and bone mineral density showed some increase in bone density, so there is a true impact on bone mineral density. This can help with injury recovery during your cycle.

Other possible benefits of MK-677 are associated with improved sleep, improved complexion, increase in energy levels, increase nitrogen retention, increase strength and an improved sense of well being. In addition, some studies also suggest that an increased immune system response was caused by Mk-677, meaning it boosts the immune system to a degree.

Results have been shown from doses between 5-25mgs a day, dose dependent results should be expected. Higher doses, over 50mgs, have been reported by some, but I don’t see the need to overdo it.