Bouncers MK-677 (Ibutamoren) Log

[chuckz28]

Interesting. Been a while since doing something other than test right? I'll be interested to see what you think of it. When do you start?

[Bouncer]

For those that don't know what MK-677 is:

Ibutamoren (INN) (developmental code names MK-677, MK-0677, L-163,191) is a non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including GH and insulin-like growth factor 1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity.

http://press.endocrine.org/doi/full/...jcem.83.2.4551

"A total of 416 patients completed treatment and assessments at 12 months. Administration of MK-677 25 mg resulted in a 60.1% increase in serum IGF-1 levels at 6 weeks and a 72.9% increase at 12 months" Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial. - PubMed - NCBI

"MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism." MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. - PubMed - NCBI

Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women. Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral den... - PubMed - NCBI

[Bouncer]

Should be noted that I'm running this drug for more then just vanity. Iv'e been having some soft tissue/tendon/joint issue on my left shoulder/spine area. The hope is the increased water retention/igf-1/GH will help a little with repair. Not expecting a miracle but even a small improvement would be welcomed.

[Bouncer]

Bouncers MK-677 (Ibutamoren) Log

I saw Turbos log and conclusion but it was a bit lazily done IMO.. sorry Turbo. :grin: I feel that if it's anything like real GH it will have very subtle results and only someone who has real GH experience will be able to compare. I've seen a few logs with people running MK-677 and people get the same sides as GH (water retention, numb swollen hands, tired feeling etc..) but for some reason people expect to see steroid like results within a month or 2. This is NOT how real injectable GH works so why would MK-677 work any differently?

I will be running 25mgs first thing in the morning with a 5 day on 2 day off schedule. Apparently there is some resistance seen around the 4th-5th day that can be reversed by simply coming off for 2 days.

I will give MK-677 a full 3 months test and give it the time to do its thing. I will update weekly every Monday morning so be sure to check back.