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Hi! After checking out different boards I decided to join here as from what I read so far the community seems open minded and helpful. I certainly could use both :)
Here’s my situation: taking the birth control pill 7 years ago exacerbated a Mast Cell Activation Syndrome that was dormant. My immune system became paranoid and reacts to common environmental factors as if they were scary allergens, inducing a constant state of anaphylaxis of varying intensity. At its worst it caused: severely impaired cognitive abilities, debilitating chronic pain and fatigue, oedema worthy of the Michelin Man, anxiety, depression, constant nausea, frequent daily vomiting and despite the latter, gaining 100 pounds in less than a year. Unfortunately it is a rare and unknown disease so doctors weren't particularly helpful.
Two years ago I started looking into all scientific studies that were published regarding mast cell stabilization and histamine reduction and began guinea pigging myself with all things reasonable under the sun (and I'll admit some that weren’t, I guess desperation does not always breed caution :P). I found many compounds that were of great help and today many of my chronic symptoms are reduced (YAY!) and I can lead a semi normal life. Despite my best efforts, weight loss is exasperatingly slow. Not that I’m particularly vain, but I do miss my heels and sexy dresses, plus I can’t help but hope that returning to a healthier weight might improve my remaining symptoms. Exercise increases histamine as such I cannot do heavy workouts without going into anaphylaxis. After trying pretty much everything, I’ve adopted a strict ketogenic diet and intermittent fasting, the only things that have worked. However even with a will of steel, I lose about 1-2 pounds a month. It’s exasperating!
So I started looking into peptides. On top of the fat loss aspect there are a slew of benefits for someone like me, like bone density (MCAS causes osteoporosis) Because MCAS is exacerbated by hormones, I decided on Ipamorelin (300mcg x 3 daily), CJC-1295 dac (1x week) and Frag 176-191(150mcg x 3 daily) as from what I could understand they are the least disruptive. Lo and behold, I started losing weight like a normal person! An amazing upside was also that all of a sudden I was able to do reasonable amounts of exercise without triggering an attack, I finally had some energy for the first time in years and I wasn’t cold all the time. However being on a very limited budget, I eventually had to stop.
Now that I’ve taken you through the scenic route, here is where I am at: in total (including the periods without peptides) I lost 70 pounds. I saved some money and opted for a cheaper regimen: GHRP-6 and MOD GRF at 100mcg x 2 daily (upon waking and going to bed). I read that GHRP-6 barely has an effect on cortisol and prolactin at that dose. There was a blowout sale for IGF-LR3 and I decided to splurge to get it, not only for its fat loss also but its anti-inflammation and regenerative properties.
I’ve been doing this for 5 days. I already see an increase in exercise stamina and the increase in appetite does not bother me in the least.
For those still reading (wow! Thanks!) here are my questions:
The water retention is monstrous! It’s quite discouraging to have to pull out clothes from my jokingly nicknamed “fatlard” wardrobe once again :/ Except drinking a lot of water, are there known tricks to help with that?
I found a lot of contradicting information on cycling IGF-1 on top of the rest. Can I take it at the same time ? I’ve been injecting 50mcg x 2 daily away from the rest but if I could take them at once, that would be great.
What are the recommended length of cycles for these peptides and how long should one take a break from them in between cycles?
Lastly, are there known problems to doing such cycles for the rest of one’s life? I’m doing better but I don’t know if I’ll ever go back to my normal self. If that’s the case, keeping the weight off may be difficult, I may need assistance indefinitely but I want to weigh the pros and cons to make an informed decision before proceeding.
Thanks for reading, looking forward to your input!
Here’s my situation: taking the birth control pill 7 years ago exacerbated a Mast Cell Activation Syndrome that was dormant. My immune system became paranoid and reacts to common environmental factors as if they were scary allergens, inducing a constant state of anaphylaxis of varying intensity. At its worst it caused: severely impaired cognitive abilities, debilitating chronic pain and fatigue, oedema worthy of the Michelin Man, anxiety, depression, constant nausea, frequent daily vomiting and despite the latter, gaining 100 pounds in less than a year. Unfortunately it is a rare and unknown disease so doctors weren't particularly helpful.
Two years ago I started looking into all scientific studies that were published regarding mast cell stabilization and histamine reduction and began guinea pigging myself with all things reasonable under the sun (and I'll admit some that weren’t, I guess desperation does not always breed caution :P). I found many compounds that were of great help and today many of my chronic symptoms are reduced (YAY!) and I can lead a semi normal life. Despite my best efforts, weight loss is exasperatingly slow. Not that I’m particularly vain, but I do miss my heels and sexy dresses, plus I can’t help but hope that returning to a healthier weight might improve my remaining symptoms. Exercise increases histamine as such I cannot do heavy workouts without going into anaphylaxis. After trying pretty much everything, I’ve adopted a strict ketogenic diet and intermittent fasting, the only things that have worked. However even with a will of steel, I lose about 1-2 pounds a month. It’s exasperating!
So I started looking into peptides. On top of the fat loss aspect there are a slew of benefits for someone like me, like bone density (MCAS causes osteoporosis) Because MCAS is exacerbated by hormones, I decided on Ipamorelin (300mcg x 3 daily), CJC-1295 dac (1x week) and Frag 176-191(150mcg x 3 daily) as from what I could understand they are the least disruptive. Lo and behold, I started losing weight like a normal person! An amazing upside was also that all of a sudden I was able to do reasonable amounts of exercise without triggering an attack, I finally had some energy for the first time in years and I wasn’t cold all the time. However being on a very limited budget, I eventually had to stop.
Now that I’ve taken you through the scenic route, here is where I am at: in total (including the periods without peptides) I lost 70 pounds. I saved some money and opted for a cheaper regimen: GHRP-6 and MOD GRF at 100mcg x 2 daily (upon waking and going to bed). I read that GHRP-6 barely has an effect on cortisol and prolactin at that dose. There was a blowout sale for IGF-LR3 and I decided to splurge to get it, not only for its fat loss also but its anti-inflammation and regenerative properties.
I’ve been doing this for 5 days. I already see an increase in exercise stamina and the increase in appetite does not bother me in the least.
For those still reading (wow! Thanks!) here are my questions:
The water retention is monstrous! It’s quite discouraging to have to pull out clothes from my jokingly nicknamed “fatlard” wardrobe once again :/ Except drinking a lot of water, are there known tricks to help with that?
I found a lot of contradicting information on cycling IGF-1 on top of the rest. Can I take it at the same time ? I’ve been injecting 50mcg x 2 daily away from the rest but if I could take them at once, that would be great.
What are the recommended length of cycles for these peptides and how long should one take a break from them in between cycles?
Lastly, are there known problems to doing such cycles for the rest of one’s life? I’m doing better but I don’t know if I’ll ever go back to my normal self. If that’s the case, keeping the weight off may be difficult, I may need assistance indefinitely but I want to weigh the pros and cons to make an informed decision before proceeding.
Thanks for reading, looking forward to your input!
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