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It appears that it alters proteins within dopamine transporter, that causes desensitization lasting twice as long as the cycle length. This can liberate many different side effects depending on the neurochemical makeup of the user.
Nandrolone is also a competitive inhibitor of brain 5-alpha reductase. This means that, DHT synthesis will be competitively inhibited in the brain, favouring DHN. DHT is important as its metabolites are potent neurosteroids capable of anxiolytic, antidepressant effect, along with increased BDNF expression. Not only that. without DHT in the brain, you lose a good portion of hormone driven drive and motivation - which is similar in tangent as Dopamine neurotransmission.
Nandrolone in it self does not raise Prolactin. Infact, relative to equal doses of testosterone, nandrolone been shown to decrease prolactin. It only becomes an issue when the two are combined, causing Prolactin synergism.
So, it kinda sucks that nandrolone being a pretty decent anabolic steroid, but harbouring these nasty neurological side effects which are somewhat impossible to overcome unless you are generally, as a person, desensitised to stimuli.
Also you should be aware that, most users last around 6 weeks into a blast before they are ravished with fatigue and just symptoms that resemble adrenal burnout. Some of that could be actually true as adrenal hormone synthesis is also altered during AAS usage.
Active intermediates in the cortisol synthesis pathway are also heavily altered during AAS. This usually has an accumulative effect over a number of weeks, which kind of explains why burnout occurs at 6 weeks. This along with changes in neurosteroid production changes stress threshold.
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Nandrolone is also a competitive inhibitor of brain 5-alpha reductase. This means that, DHT synthesis will be competitively inhibited in the brain, favouring DHN. DHT is important as its metabolites are potent neurosteroids capable of anxiolytic, antidepressant effect, along with increased BDNF expression. Not only that. without DHT in the brain, you lose a good portion of hormone driven drive and motivation - which is similar in tangent as Dopamine neurotransmission.
Nandrolone in it self does not raise Prolactin. Infact, relative to equal doses of testosterone, nandrolone been shown to decrease prolactin. It only becomes an issue when the two are combined, causing Prolactin synergism.
So, it kinda sucks that nandrolone being a pretty decent anabolic steroid, but harbouring these nasty neurological side effects which are somewhat impossible to overcome unless you are generally, as a person, desensitised to stimuli.
Also you should be aware that, most users last around 6 weeks into a blast before they are ravished with fatigue and just symptoms that resemble adrenal burnout. Some of that could be actually true as adrenal hormone synthesis is also altered during AAS usage.
Active intermediates in the cortisol synthesis pathway are also heavily altered during AAS. This usually has an accumulative effect over a number of weeks, which kind of explains why burnout occurs at 6 weeks. This along with changes in neurosteroid production changes stress threshold.
Sent from my SM-G950F using Tapatalk
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