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How to convert Androstendione to TNE
Editor's Note: In the US, this chemical procedure is illegal. Additionally, the by-products of the various androstenediols may fall under the Federal Analogue Act, which schedules derivatives of any DEA-controlled drug (in this case testosterone) into a Control I substance. So in effect, this procedure outlined is a hypothetical exercise designed to show a possible conversion of androstenedione to testosterone.
The procedure outlined below won't convert 100% of androstenedione to testosterone. But it will convert at least 60% of it, if the procedure is not screwed up too badly. The other percentage of finishied product will contain a small amount of unreacted androstenedione and a larger amount of a (epimeric) mixture of 3,17-androstenediols, which, fortunately, are safe and considerably anabolic compounds in their own right.
Materials Needed
Androstenedione (powder)
Methanol (wood alcohol)
Sodium Borohydride (sodium tetrahydroborate)
Acetic Acid (ethanoic acid)
Distilled Water
Litmus Paper
Thermometer (Fahrenheit)
Also: Beaker or glass container for the reaction a pot for salt water ice bath, a way to stir (i.e. spoon), filter, eyedropped (1 or 2cc size).
Procedure
1)10 grams of androstenedione is dissolved in 400ml methanol and cooled to 32deg Fahrenheit in a salt/ice bath (similar to chilling home-made ice cream).
2)2.5g sodium borohydride is added while the solution is stirred.
3)The solution is continually stirred for 45 minutes while the temperature is maintained as close to 32deg Fahrenheit as possible.
4)After 45 minutes, acetic acid is added to the solution, while stirring, in increments of approximately 2ml at a time (hydrogen gas will evolve).
WARNING!
Hydrogen Gas can ignite from flame or spark.
5)After each addition of acetic acid, thepH of the solution should be checked.
6)When the pH just begins to turn acidic on the litmus paper, then the addition of acetic acid should be stopped.
7)The methanol solution is now concentrated by evaporation until the volume is around 50ml.
WARNING!
Hydrogen gas may still be present; it can ignite from flame or spark.
8)This concentrated methanol solution is then mixed with 700ml water.
The cloudy precipitate that forms is filtered off and the filter cake is washed extensively (several times) with water.
9)The filter cake can be air (sun) dried for several days or dried in an oven for several hours at a temperature no higher than 150deg Fahrenheit.
The finished product, a fine white powder, should contain approximately 60 to 80% testosterone, with lesser amounts of unreacted androstenedione and a mixture of 3-alpha, 17-beta, and 3-beta, 17-beta androstenediols.
What should be done with this (now highly illegal) stuff once the procedure is finished?
Since it is highly illegal I would advocate getting rid of it.
Yet if someone wanted to take the risk and decided to use it, they would probably wonder if it should be taken orally or what?
I would not suggest that anyone take it orally because the purpose of the experiment would be defeated. Since testosterone is mostly deactivated in the gut, the ingestion of the finished product would be worthless. Instead, there are better alternatives, such as making sublingual liquid by dissolving the product in a solvent such as propyleneglycol and/or ethanol. If this is done, I suggest aiming for a concentration of around 30mg/ml and taking one-third of a milliliter (about 33 insulin IUs) under the tongue as a single dose (repeated throughout the day as often as wished by the user). Another alternative is to make a transdermal DMSO solution (messy and stinky). A third course of action (for the bold ones) is to make an injectable solution.
Editor's Note: In the US, this chemical procedure is illegal. Additionally, the by-products of the various androstenediols may fall under the Federal Analogue Act, which schedules derivatives of any DEA-controlled drug (in this case testosterone) into a Control I substance. So in effect, this procedure outlined is a hypothetical exercise designed to show a possible conversion of androstenedione to testosterone.
The procedure outlined below won't convert 100% of androstenedione to testosterone. But it will convert at least 60% of it, if the procedure is not screwed up too badly. The other percentage of finishied product will contain a small amount of unreacted androstenedione and a larger amount of a (epimeric) mixture of 3,17-androstenediols, which, fortunately, are safe and considerably anabolic compounds in their own right.
Materials Needed
Androstenedione (powder)
Methanol (wood alcohol)
Sodium Borohydride (sodium tetrahydroborate)
Acetic Acid (ethanoic acid)
Distilled Water
Litmus Paper
Thermometer (Fahrenheit)
Also: Beaker or glass container for the reaction a pot for salt water ice bath, a way to stir (i.e. spoon), filter, eyedropped (1 or 2cc size).
Procedure
1)10 grams of androstenedione is dissolved in 400ml methanol and cooled to 32deg Fahrenheit in a salt/ice bath (similar to chilling home-made ice cream).
2)2.5g sodium borohydride is added while the solution is stirred.
3)The solution is continually stirred for 45 minutes while the temperature is maintained as close to 32deg Fahrenheit as possible.
4)After 45 minutes, acetic acid is added to the solution, while stirring, in increments of approximately 2ml at a time (hydrogen gas will evolve).
WARNING!
Hydrogen Gas can ignite from flame or spark.
5)After each addition of acetic acid, thepH of the solution should be checked.
6)When the pH just begins to turn acidic on the litmus paper, then the addition of acetic acid should be stopped.
7)The methanol solution is now concentrated by evaporation until the volume is around 50ml.
WARNING!
Hydrogen gas may still be present; it can ignite from flame or spark.
8)This concentrated methanol solution is then mixed with 700ml water.
The cloudy precipitate that forms is filtered off and the filter cake is washed extensively (several times) with water.
9)The filter cake can be air (sun) dried for several days or dried in an oven for several hours at a temperature no higher than 150deg Fahrenheit.
The finished product, a fine white powder, should contain approximately 60 to 80% testosterone, with lesser amounts of unreacted androstenedione and a mixture of 3-alpha, 17-beta, and 3-beta, 17-beta androstenediols.
What should be done with this (now highly illegal) stuff once the procedure is finished?
Since it is highly illegal I would advocate getting rid of it.
Yet if someone wanted to take the risk and decided to use it, they would probably wonder if it should be taken orally or what?
I would not suggest that anyone take it orally because the purpose of the experiment would be defeated. Since testosterone is mostly deactivated in the gut, the ingestion of the finished product would be worthless. Instead, there are better alternatives, such as making sublingual liquid by dissolving the product in a solvent such as propyleneglycol and/or ethanol. If this is done, I suggest aiming for a concentration of around 30mg/ml and taking one-third of a milliliter (about 33 insulin IUs) under the tongue as a single dose (repeated throughout the day as often as wished by the user). Another alternative is to make a transdermal DMSO solution (messy and stinky). A third course of action (for the bold ones) is to make an injectable solution.
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