Androgenicity: DHT & drostanolone

[Growing Doc.]

Could someone make some comparison of their androgenic properties? I need to understand which one binds stronger to the receptor , their potential metabolites and related enzymes and other properities.

I know i ask to much, but i will have to ask some more: plasma levels of DHT and comparison to test levels, and levels of circulant drostanolone for given drostanolone intake.

That will be all for today :D

[Doom]

wait for spidey or prolangtum, for this one buddy

[Growing Doc.]

;)

[spidey]

Re: Androgenicity: DHT & drostanolone

Originally posted by Growing Doc.
Could someone make some comparison of their androgenic properties? I need to understand which one binds stronger to the receptor , their potential metabolites and related enzymes and other properities.

I know i ask to much, but i will have to ask some more: plasma levels of DHT and comparison to test levels, and levels of circulant drostanolone for given drostanolone intake.

That will be all for today :D

LOL, you don't ask for much.....(not).

Drostanolone is 2a-methyl-DHT. Since it is thought that binding to the AR occurs from the alpha side of the steroid, pretty much any alpha substitutions are predicted to decrease AR binding. Based on that and some ancedotal evidence, I predict drostanolone will be less androgenic than DHT. I am unsure by how much though.

Incidently, this is especially true for the 1-position. 1a-Methyl analogs are always much less androgenic than the unmethylated versions; 1a-ethyl analogs often do not bind AT ALL!

There is a new member named Sigmund Roid who has a lot of experience with drostanolone. He also has a scientific background and may be able to better answer your questions.

[spidey]

Oh yeah, potential metabolites would likely be similar to DHT, just 2a-methylated. The major metabolites would include 2a-methyl androstanedione, 2a-methyl androstane-3,17-diol.

With testosterone metabolism, the dione and diol metabolites make up 90% of the metabolites. The other 10% are one or two hydroxylated metabolites. I don't recall which carbon positions are hydroxylated. The enzymes responsible for these oxidations (and reductions) are hepatic cytochrome p450's. Since there is no 4,5 double bond in either drostanolone or DHT, they are not substrates for 5alpha-reductase or aromatase.

[Growing Doc.]

Mr. Spidey, always full of useful knowledge!

Thanks a lot my friend!