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The Effects Of NSAIDs On Muscle Gaines
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References:
Mackey, Abigail L., et al. "Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication." The FASEB Journal (2016): fj-201500198R.
32 untrained, but healthy young men were recruited and randomly assigned to consume either NSAID [1200 mg/d ibuprofen (IBU)] or placebo (PLA) daily for 2 wk before and 4 wk after an electrical stimulation–induced injury to the leg extensor muscles of one leg.
To assess, whether the ingestion of ibuprofen would, as the scientists suspected alter satellite cell response and time course of regeneration in the experimentally injured skeletal muscle of young healthy men, biopsies were collected from the vastus lateralis muscles before and after stimulation (2.5 h and 2, 7, and 30 d) and were assessed for satellite cells and regeneration by immunohistochemistry and real-time RT-PCR. In conjunction with the likewise measured length of the telomeres, the scientists expected to be able to determine the actual effect of NSAIDs on the post-exercise recovery process.
What the researchers found was appears to be a clear advantage... initially: After injury, and compared with PLA, IBU was found to augment the proportion of ActiveNotch1+ satellite cells at 2 d [IBU, 29 +/- 3% vs. PLA, 19 +/- 2% (means +/- SEM)], satellite cell content at 7 d [IBU, 0.16 +/- 0.01 vs. PLA, 0.12 6 0.01 (Pax7+ cells/fiber)], and to expedite muscle repair at 30 d.
The bad news is that the chronic consumption of NSAIDs is nothing a healthy individual should consider - even if it prevents your muscle from collagen depositions and still, if we could get the benefits observed in the study at hand without the potential long-term side effects of common NSAIDs, they could be a game changer... at least for elderly individuals, in whom the recruitment of satellite cells and thus process of muscle repair appears to be impaired by aging.
To assess, whether the ingestion of ibuprofen would, as the scientists suspected alter satellite cell response and time course of regeneration in the experimentally injured skeletal muscle of young healthy men, biopsies were collected from the vastus lateralis muscles before and after stimulation (2.5 h and 2, 7, and 30 d) and were assessed for satellite cells and regeneration by immunohistochemistry and real-time RT-PCR. In conjunction with the likewise measured length of the telomeres, the scientists expected to be able to determine the actual effect of NSAIDs on the post-exercise recovery process.
What the researchers found was appears to be a clear advantage... initially: After injury, and compared with PLA, IBU was found to augment the proportion of ActiveNotch1+ satellite cells at 2 d [IBU, 29 +/- 3% vs. PLA, 19 +/- 2% (means +/- SEM)], satellite cell content at 7 d [IBU, 0.16 +/- 0.01 vs. PLA, 0.12 6 0.01 (Pax7+ cells/fiber)], and to expedite muscle repair at 30 d.
The bad news is that the chronic consumption of NSAIDs is nothing a healthy individual should consider - even if it prevents your muscle from collagen depositions and still, if we could get the benefits observed in the study at hand without the potential long-term side effects of common NSAIDs, they could be a game changer... at least for elderly individuals, in whom the recruitment of satellite cells and thus process of muscle repair appears to be impaired by aging.
References:
Mackey, Abigail L., et al. "Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication." The FASEB Journal (2016): fj-201500198R.