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Cannabis Users Are Getting Fat

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  • Cannabis Users Are Getting Fat



    Researchers at Michigan State University have shed light on the potential mechanisms by which activated cannabinoid receptors influence the likelihood of weight gain and obesity.

    Their study indicated that the absence of these receptors confers protection from diet-induced obesity, possibly mainly as a result of the role cannabinoid-1 receptor (CB1R) plays in obesity or due to a combined, interactive effect of both CB1R and cannabinoid-2 receptor (CB2R).

    The findings, which were published earlier this year in the journal Obesity, could help to explain conflicting findings from previous studies looking at how the receptors contribute to the regulation of glucose metabolism and body weight.



    Conflicting Findings Among Cannabis Users

    Many studies have reported on the appetite-stimulating effects of the active constituent in cannabis − delta-9-tetrahydrocannabinol (THC) − and evidence suggests that increased food intake and weight gain among cannabis users is associated with activation of CB1R.

    In rodents, administration of CB1R agonists such as rimonabant decrease food intake and weight gain. In humans, rimonabant exerts similar effects, reducing body weight, as well as improving other aspects of the metabolic syndrome. In agreement, some studies have found that cannabis users tend to have a higher calorie intake than non-users.

    Accordingly, the activation of cannabinoid receptors and increased calorie intake among people using cannabis could be expected to show a positive association with the development of obesity and type 2 diabetes. However, some epidemiological studies have in fact shown a reduced prevalence of obesity, insulin resistance and diabetes among cannabis users.

    Studies elucidating the role of CB2R in weight gain have not been as conclusive as those looking at CB1R.

    In one 2015 study published in PLoS One, Brian Oldfield and colleagues found that the administration of one type of CB2R agonist was associated with a reduced food intake and body weight in obese mice. By contrast, a 2016 study by A Jenkins and colleagues published in the British Journal of Pharmacology found that treatment with another agonist did not reduce food intake or weight gain in diet-induced obese rodents.

    Overlapping and Complementary Function of CB1R and CB2R

    CB1R and CB2R recognize the same structural groups of agonists, including THC, but sometimes with different affinities. Given that CB1R and CB2R have overlapping and complementary functions, Karl Olson and colleagues at Michigan State University decided to study mice lacking CB2R (CB2−/− mice) and mice lacking both CB1R and CB2R (CB-DKO mice) to further elucidate the receptors’ contribution to the regulation of body weight and glucose metabolism.

    A high-fat diet was fed ad libitum to age-matched male CB2−/− mice and CB-DKO mice for 12 weeks in order to assess metabolic changes, compared with wild-type mice fed the same diet. Food intake, body weight and composition were measured weekly for 12 weeks.

    Leanness may be Predominantly CB1R-mediated or Due to an Interactive Effect of both Receptors

    The authors suggest that given the established role of CB1R in energy balance, the leanness and altered thermogenesis in CB-DKO mice could be driven by CB1R, although they warn that this conclusion is limited by the fact that a CBR1 knockout model was not included in the study.

    They also point out that this CB-DKO phenotype could be the result of a unique interactive effect of both receptors, rather than due to a predominant role of CBR1 in obesity.

    Either way, Olson and team speculate that downregulation of cannabinoid receptors may account for the decreased prevalence of obesity and insulin resistance among cannabis users.

  • #2
    I'm not surprised by this at all. Cannabis is notorious for hunger and food binges in some people.

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    • #3
      Originally posted by Ashop View Post
      I'm not surprised by this at all. Cannabis is notorious for hunger and food binges in some people.
      and higher estrogen levels

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      • #4
        Ohh that explains. Thanks for sharing this post!

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