Microbiome

[AvidFisherman]

http://www.sciencedaily.com/releases...1214130811.htm

This could be why I've been having such a hard time loosing weight. Up until last month I was on a high dose of risperidone for some ocd and sleep issues.

[Bouncer]

Does it say if the effects are permanent or temporary? Did the mice lose the weight after they stopped taking the drug?

[AvidFisherman]

It did not say. I am going to look up and read the study tonight. A guess is, since I am no longer taking the drug it will not continue to adversely affect my gut bacteria and through eating a lot of veggies and other whole foods it will repair itself.

[AvidFisherman]

The study does not say anything about recovery.

"Mirroring the human studies, the researchers showed that risperidone causes weight gain in mice (an extra 2.5 grams, or approximately 10 percent of the total body mass, over two months compared to controls) and significantly alters the bacterial composition of the mouse microbiome. They then showed that the altered microbiome causes a reduction in resting metabolic rate that is entirely responsible for the excess weight gain."

"It's about a 16 percent change in resting metabolic rate, which is enormous," Grobe says. "It would be 29 pounds of fat gained every year for an average human."

"For example, for a 2000 kcal/day human, roughly 80% of total energy expenditure (1600 kcal/day) occurs in the form of RMR. A 16% reduction in total RMR would therefore equate to increasing energy retention by ~260 kcal/day, nearly equivalent to consuming an extra standard McDonald's cheeseburger (290 kcal) (McDonald's Nutrition, 2015) each day — a decidedly obesigenic maneuver."

[Bouncer]

I was just about to post that part about the 29lbs gained per year. Christ that's insane.

The other part i'm interested in is if we can slow down fat burning via gut microbes there must be a way to "super charge" the microbes to burn more fat than normal.

[Turbo3000]

Weight gain is a common side effect of antipsychotic drugs. We basically have typical and atypical antipsychotic drugs. The atypical drugs were formulated in hopes of reducing some common side effects.

Talk to your doctor about Geodon if you need to take that class of medication again. It doesn't have as many issues with weight gain.

[AvidFisherman]

He switched me to trazodone.