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Grape Seed Extract Improves Muscle Recovery
Muscle, Inflammation & Grape Seed Extract
Muscle tissue damage – as a result of heavy training or from taking blows or a fall – results in inflammatory reactions in the body. Plant-based compounds such as proanthocyanidolic oligomers in grape seed extract inhibit inflammation.
Extrapolation: plant-based compounds such as proanthocyanidolic oligomers speed up the recovery of damaged muscles.
Study
Nice theory, but does it work in practice? This is the question the South Africans set out to answer by doing an experiment in which they anaesthetised male rats and then caused muscle bruising by dropping a weight on their hind legs. For a period of 14 days they gave one group of rats a placebo every day [Pl-PLA] and another group 20 mg grape seed extract per kg bodyweight daily [Pl-PCO].
The researchers used Oxiprovin, a grape seed extract made by the South African company Brenn-O-Kem, which consists of 45 percent proanthocyanidolic oligomers. The human equivalent of the dose they used would be 140 mg per kg per day. The supplement was given orally.
Results
In the rats that had been given grape seed extract there was a faster decrease in the amount of inflammatory proteins such as IL-1-beta and TNF-alpha in their blood.
The grape seed extract boosted the production of foetal myosin heavy chain in the damage muscle tissue. Foetal myosin heavy chain is an indicator of muscle fibre recovery.
Conclusion
Fundamental research has shown that macrophages also play a key role in anabolic processes that arise after exceptional physical exertion. So might bodybuilders also benefit from grape seed extract?
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Source:
Med Sci Sports Exerc. 2012 May;44(5):872-80.
Muscle tissue damage – as a result of heavy training or from taking blows or a fall – results in inflammatory reactions in the body. Plant-based compounds such as proanthocyanidolic oligomers in grape seed extract inhibit inflammation.
Extrapolation: plant-based compounds such as proanthocyanidolic oligomers speed up the recovery of damaged muscles.
Study
Nice theory, but does it work in practice? This is the question the South Africans set out to answer by doing an experiment in which they anaesthetised male rats and then caused muscle bruising by dropping a weight on their hind legs. For a period of 14 days they gave one group of rats a placebo every day [Pl-PLA] and another group 20 mg grape seed extract per kg bodyweight daily [Pl-PCO].
The researchers used Oxiprovin, a grape seed extract made by the South African company Brenn-O-Kem, which consists of 45 percent proanthocyanidolic oligomers. The human equivalent of the dose they used would be 140 mg per kg per day. The supplement was given orally.
Results
In the rats that had been given grape seed extract there was a faster decrease in the amount of inflammatory proteins such as IL-1-beta and TNF-alpha in their blood.
The grape seed extract boosted the production of foetal myosin heavy chain in the damage muscle tissue. Foetal myosin heavy chain is an indicator of muscle fibre recovery.
Conclusion
Fundamental research has shown that macrophages also play a key role in anabolic processes that arise after exceptional physical exertion. So might bodybuilders also benefit from grape seed extract?
__________________________
Source:
Med Sci Sports Exerc. 2012 May;44(5):872-80.