Questions from a new dude

[liftsiron]

I could take you same argument and say, "if nolvadex worked like you said, nobody would use steroids." Its a stupid statement and you know it. We are talking about bringing test levels back to normal when they are low. An AI or a SERM would never replace a steroid..

Here are a few quick reads for you..

In one clinical study Letrozole was able to reduce estrogen levels to undetectable levels (2), and in another clinical study done on both young and elderly men, intravenous administration of Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the elderly subjects. Because estrogen is part of the negative feedback loop of the hpta - hypothalamic-pituitary-testicular axis - - hypothalamic-pituitary-testicular axis - , Letrozole (and other anti-estrogens) are able to raise testosterone in male subjects. Letrozole was studied in men, and found to significantly increase lh - leutenizing hormone - - leutenizing hormone - levels to a 339 and 323% in the young and the elderly, respectively and testosterone by 146 and 99%, respectively. (3) Letrozole was also able to produce a peak lh - leutenizing hormone - response to Gonadatropin Releasing Hormone equal to a 152 and 52% increase from baseline in either young or older men, respectively (3). In a similar study 0.02 mg of Letrozole increased testosterone by 45% after 2 days. (4) That same twenty micrograms of Letrozole was also enough, in one study done on men, to reduce estrogen levels by roughly a third. (4)


(read through this whole thing) http://joe.endocrinology-journals.or.../182/1/165.pdf


Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism. Letrozole once a week normalizes serum testosteron... [Eur J Endocrinol. 2008] - PubMed result

I will read through the study as it's a good find. However this study was inducing letro in the blood system by IV, we don't know if oral admin would garner the same results, although with this drug I would suspect that results would be similar. Also without a given numerical baseline we don't know if 339% and 323% is significant. Also this study was done with men that had a functioning HTPA with reduced function by over exposure to estrogen. Not an HTPA that shut down by exo test injections. Never the less a very worth while find.

[liftsiron]

Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism.

Loves S, Ruinemans-Koerts J, de Boer H.

Department of Internal Medicine, Ziekenhuis Rijnstate, Wagnerlaan 55, 6800 TA Arnhem, The Netherlands.
Abstract

OBJECTIVE: Isolated hypogonadotropic hypogonadism (IHH) is frequently observed in severely obese men, probably as a result of increased estradiol (E(2)) production and E(2)-mediated negative feedback on pituitary LH secretion. Aromatase inhibitors can reverse this process. This study evaluates whether letrozole once a week can normalize serum testosterone in severely obese men and maintain its long term effect.

DESIGN: Open, uncontrolled 6-month pilot study in 12 severely obese men (body mass index>35.0 kg/m(2)) with obesity-related IHH and free testosterone levels <225 pmol/l, treated with 2.5 mg letrozole once a week for 6 months.

RESULTS: Six weeks of treatment reduced total E(2) from 123+/-11 to 58+/-7 pmol/l (P<0.001, mean+/-s.e.m.), and increased serum LH from 4.4+/-0.6 to 11.1+/-1.5 U/l (P<0.001). Total testosterone rose from 5.9+/-0.5 to 19.6+/-1.4 nmol/l (P<0.001), and free testosterone from 163+/-13 to 604+/-50 pmol/l (P<0.001). Total testosterone rose to within the normal range in all subjects, whereas free testosterone rose to supraphysiological levels in 7 out of 12 men. The testosterone and E(2) levels were stable throughout the week and during the 6-month treatment period.

CONCLUSION: Letrozole 2.5 mg once a week produced a sustained normalization of serum total testosterone in obese men with IHH. However, free testosterone frequently rose to supraphysiological levels. Therefore, a starting dose <2.5 mg once a week is recommended.

PMID: 18426834 [PubMed - indexed for MEDLINE]Free Article



Could we expect positive results in normal weight men or healthy weight trained men who already have normal test levels? No doubt there would be somewhat of a raise in test due to interrupted conversion of test to estro. Would it be noticeable in the gym... I wonder?

[Bouncer]

just cut to the chase, you now agree with me. more over, you were wrong. admit defeat and bow to the victor!

[liftsiron]

just cut to the chase, you now agree with me. more over, you were wrong. admit defeat and bow to the victor!

A serm is proper for pct not an AI unless used in conjunction with an AI. Though in the hypogonal severely obese letro does seem of benefit in bringing
test back to normal levels by lowering estrogen.

[Bouncer]

A serm is proper for pct not an AI unless used in conjunction with an AI. Though in the hypogonal severely obese letro does seem of benefit in bringing
test back to normal levels by lowering estrogen.

no, you can use an AI alone and it will raise test levels.

[lowcashcowboy]

Would either of you guys happen to know if aas will show up in a DOT regulated drug screen?

[Bouncer]

No, they aren't testing for steroids.

[lowcashcowboy]

I'm suprised they are a bunch of bitches