Effect of cannabis on glutamate signalling in the brain: A systematic review of human

[boricuarage79]

and what does any of that mean in simple terms? it helps people who have fucked up dopamine levels or what?

Two main neurotransmitters. Gaba(chilled/calmed) and glutamate(focus/excitement). What benzo does it downregulates your gaba receptors and increases glutamate. Not good when there is no balance.
You feel off and suicidal sometimes when waves hit.
I haven't drank a whey protein or taking bcass. Because whey has glutamine and the other aminos that increase glutamate.

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[boricuarage79]

Cannabis has helped me alot during benzos withdrawals. I am almost down to my lowest taper dose of 2mgs. Without canna i would be a wreck. Lowers glutamate while gaba receptors heal. Been a long 10 years of use.

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[Bouncer]

and what does any of that mean in simple terms? it helps people who have fucked up dopamine levels or what?

[boricuarage79]

Abstract

Use of cannabis or delta-9-tetrahydrocannabinol (Δ9-THC), its main psychoactive ingredient, is associated with psychotic symptoms or disorder. However, the neurochemical mechanism that may underlie this psychotomimetic effect is poorly understood. Although dopaminergic dysfunction is generally recognized as the final common pathway in psychosis, evidence of the effects of Δ9-THC or cannabis use on dopaminergic measures in the brain is equivocal. In fact, it is thought that cannabis or Δ9-THC may not act on dopamine firing directly but indirectly by altering glutamate neurotransmission. Here we systematically review all studies examining acute and chronic effects of cannabis or Δ9-THC on glutamate signalling in both animals and man. Limited research carried out in humans tends to support the evidence that chronic cannabis use reduces levels of glutamate-derived metabolites in both cortical and subcortical brain areas. Research in animals tends to consistently suggest that Δ9-THC depresses glutamate synaptic transmission via CB1 receptor activation, affecting glutamate release, inhibiting receptors and transporters function, reducing enzyme activity, and disrupting glutamate synaptic plasticity after prolonged exposure.


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